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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-07-2004 | Laboratory Investigation

Pharmacokinetics and safety of intravitreally delivered etanercept

Authors: Sascha Fauser, Hubert Kalbacher, Nils Alteheld, Kan Koizumi, Tim U. Krohne, Antonia M. Joussen

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 7/2004

Abstract

Background

The anti-inflammatory drug etanercept may be an effective therapeutic agent in diabetic retinopathy. In order to further evaluate its potential, the pharmacokinetics and safety of this drug after intravitreal delivery were investigated.

Methods

After intravitreal administration of etanercept in rabbits, clinical examination, electroretinography (ERG), visually evoked potentials (VEP) and histology were evaluated. The pharmacokinetics and distribution of etanercept were analyzed using fluorescence-coupled protein at 0, 2, 4, and 8 weeks after injection in vitreous, retina, and choroid.

Results

No adverse effects and signs of toxicity were found. Etanercept showed peak concentrations after 4 weeks in the retina and choroid.

Conclusions

Intravitreally delivered etanercept is safe and results in high concentrations in the retina and choroid over a long period of time.

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Title: Pharmacokinetics and safety of intravitreally delivered etanercept
Authors: Sascha Fauser
Hubert Kalbacher
Nils Alteheld
Kan Koizumi
Tim U. Krohne
Antonia M. Joussen
Publication date: 01-07-2004
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 7/2004
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-004-0895-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Pharmacokinetics and safety of intravitreally delivered etanercept

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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