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01-12-2006 | Review Article

Pharmacogenetics of Target Genes Across the Warfarin Pharmacological Pathway

Authors: Suman Lal, Srinivasa Rao Jada, Xiaoqiang Xiang, Wan-Teck Lim, Edmund J. D. Lee, Dr Balram Chowbay

Published in: Clinical Pharmacokinetics | Issue 12/2006

Abstract

Warfarin is a widely prescribed anticoagulant for thromboembolic disorders and exhibits wide inter-individual differences in its pharmacodynamic effects. Warfarin exerts its anticoagulant effect by inhibiting the enzymatic activity of vitamin K 2,3-epoxide reductase complex, subunit 1 (VKORC1) which regenerates reduced vitamin K as an essential cofactor for the post-translational γ-carboxylation of glutamic acid residues on coagulation factors II, VII, IX and X, and the anticoagulant proteins C, S and Z. Recent studies have shown polymorphisms in genes involved in the uptake of vitamin K (apolipoprotein E [ApoE]), reduction of vitamin K 2,3-epoxide (VKORC1), metabolism of warfarin (cytochrome P450 2C9 [CYP2C9]), and gamma carboxylation (γ-glutamyl carboxylase [GGCX]) to influence the pharmacokinetics and pharmacodynamics of warfarin in patients from different ethnic backgrounds, resulting in variable warfarin dose requirements. Understanding the causal relationship of these polygenic influences on warfarin dose requirements in patients of different ethnicity may be vital in reducing inter-patient variability and optimising anticoagulant therapy.

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Title: Pharmacogenetics of Target Genes Across the Warfarin Pharmacological Pathway
Authors: Suman Lal
Srinivasa Rao Jada
Xiaoqiang Xiang
Wan-Teck Lim
Edmund J. D. Lee
Dr Balram Chowbay
Publication date: 01-12-2006
Publisher: Springer International Publishing
Published in: Clinical Pharmacokinetics / Issue 12/2006
Print ISSN: 0312-5963
Electronic ISSN: 1179-1926
DOI: https://doi.org/10.2165/00003088-200645120-00004

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Pharmacogenetics of Target Genes Across the Warfarin Pharmacological Pathway

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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