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01-05-2014 | Genetics (AJ Marian, Section Editor)

Pharmacogenetics of Antiplatelet Therapy

Authors: Patrick L. Daly, Richard C. Becker

Published in: Current Atherosclerosis Reports | Issue 5/2014

Abstract

There has been substantial progress toward understanding and investigating the specific genetic factors that influence interindividual variations in platelet-directed therapy. There has also been substantial progress toward better understanding of the pharmacogenetics of drug metabolism and phamacodynamic response to platelet antagonists. We summarize the relationship between genetic polymorphisms, response to platelet antagonists, and clinical impact on patient treatment for the commonly used antiplatelet drugs. The challenge faced in translating genotype identification into improved clinical outcomes reflects the complexity involved in the genomic influence on drug metabolism and activation.

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Title: Pharmacogenetics of Antiplatelet Therapy
Authors: Patrick L. Daly
Richard C. Becker
Publication date: 01-05-2014
Publisher: Springer US
Published in: Current Atherosclerosis Reports / Issue 5/2014
Print ISSN: 1523-3804
Electronic ISSN: 1534-6242
DOI: https://doi.org/10.1007/s11883-014-0411-7

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