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Published in: Nuclear Medicine and Molecular Imaging 4/2015

01-12-2015 | Review

PET Radioligands for Imaging of Tau Pathology: Current Status

Authors: Yearn Seong Choe, Kyung-Han Lee

Published in: Nuclear Medicine and Molecular Imaging | Issue 4/2015

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Abstract

The incidence of Alzheimer’s disease (AD), a progressive neurodegenerative disorder, continues to soar with the rapid growth of the elderly population, thus creating an enormous social and economic burden. Although disease-modifying drugs to treat AD are not yet available, several candidate drugs are in clinical trials. Most of these drugs are expected to be effective at the early stages of the disease, and therefore the early and accurate diagnosis of AD will be a critical factor in efforts to improve the prognosis of patients with AD. This review focuses on lead radioligands developed to date and their preclinical data in order to facilitate the development of tau-specific positron emission tomography radioligands that are of great interest to the scientific community.
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Metadata
Title
PET Radioligands for Imaging of Tau Pathology: Current Status
Authors
Yearn Seong Choe
Kyung-Han Lee
Publication date
01-12-2015
Publisher
Springer Berlin Heidelberg
Published in
Nuclear Medicine and Molecular Imaging / Issue 4/2015
Print ISSN: 1869-3474
Electronic ISSN: 1869-3482
DOI
https://doi.org/10.1007/s13139-015-0374-9

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