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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2011

Open Access 01-02-2011 | Editorial Commentary

Permeability of dura mater: a possible link between cortical spreading depression and migraine pain? A comment

Author: Peer Carsten Tfelt-Hansen

Published in: The Journal of Headache and Pain | Issue 1/2011

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Abstract

In the wake of cortical spreading depression (CSD) it has been suggested that noxious substances diffuse through the dura with resulting firing of epidural nerves. In my view this is unlikely because there are good reasons to suggest that there must be a dura-brain barrier. Alternatively collateral branches from the trigeminal nerve to the pia and the dura may signal what is happening with ions and substances on the brain surface during CSD to the epidural space.
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Zhang XC, Levy D, Noseda R, Kainz V, Jekuboski M, Burstein R (2010) Activation of meningeal nocicsptors by cortical spreading depression: implications for migraine with aura. J Neurosci 30:8007–8814
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Baker DA, Xi Z-X, Shen H, Swanson CD, Kalivas PW (2002) The origin and neuronal function of in vivo nonsynaptic glutamate. J Neurosci 22:9134–9141, 12388621, 1:CAS:528:DC%2BD38XosV2is7c%3DPubMed
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Hawkins RA (2009) The blood-brain barrier and glutamate. Am J Clin Nutr 90:867S–874S, 19571220, 10.3945/ajcn.2009.27462BB, 1:CAS:528:DC%2BD1MXhtVKmtrvIPubMedCentralCrossRefPubMed
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Metadata
Title
Permeability of dura mater: a possible link between cortical spreading depression and migraine pain? A comment
Author
Peer Carsten Tfelt-Hansen
Publication date
01-02-2011
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2011
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1007/s10194-010-0252-x

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