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Archives of Orthopaedic and Trauma Surgery

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20-09-2021 | Periprosthetic Fracture | Hip Arthroplasty

Is primary total hip arthroplasty in patients with Down’s syndrome associated with increased complications at 2 years follow-up?

Authors: Nicholas M. Hernandez, Daniel J. Cunningham, Patrick D. Millikan, Colin T. Penrose, Thorsten M. Seyler

Published in: Archives of Orthopaedic and Trauma Surgery | Issue 10/2022

Abstract

Introduction

Previous reports on primary total hip arthroplasty (THA) in patients with Down’s syndrome (DS) are often small and/or lack a comparison cohort, and thus it is challenging to draw meaningful conclusions about this group. The purpose of this study was to report on the post-operative complications in patients with DS undergoing primary THA, compared to a non-DS cohort.

Methods

In this retrospective study, we evaluated patients from 2010 to 2018 using a national database. We assessed surgical complications: closed reduction for dislocation, revision, resection, periprosthetic fracture, and infection in patients with a diagnosis of DS undergoing primary THA and compared them to a THA group of patients without DS. Patients undergoing THA for hip fractures were excluded. Complications were evaluated at 90 days and 2 years. Multivariable logistic regression analysis was used to adjust for age, sex, body mass index, and Charlson comorbidity index.

Results

At 90 days patients with DS had an increased risk of revision (OR 3.1, CI 1.14–8.41), but no significant risk of resection (OR 5.24, CI 0.73–37.8), closed reduction (OR 2.03, CI 0.28–14.59), infection (OR 1.48, CI 0.6–3.62), or periprosthetic fracture (OR 1.97, CI 0.27–14.14). At 2 years patients with DS had an increased risk of periprosthetic fracture (OR 5.88, CI 1.84–18.78), but no significant increased risk of revision (OR 1.82, CI 0.66–5.01), resection (OR 2.37, CI 0.33–17.17), or infection (OR 0.65, CI 0.2–2.07).

Conclusions

Primary THA in patients with DS is associated with increased 90-day revision, and periprosthetic fracture at 2 years.

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Title: Is primary total hip arthroplasty in patients with Down’s syndrome associated with increased complications at 2 years follow-up?
Authors: Nicholas M. Hernandez
Daniel J. Cunningham
Patrick D. Millikan
Colin T. Penrose
Thorsten M. Seyler
Publication date: 20-09-2021
Publisher: Springer Berlin Heidelberg
Keywords: Periprosthetic Fracture
Trisomy 21
Hip-TEP
Hip-TEP
Published in: Archives of Orthopaedic and Trauma Surgery / Issue 10/2022
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI: https://doi.org/10.1007/s00402-021-04132-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Is primary total hip arthroplasty in patients with Down’s syndrome associated with increased complications at 2 years follow-up?

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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