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01-07-2006 | Original Article

Peripheral T-cell lymphoma with involvement of the expanded mantle zone

Authors: Ida Münster Ikonomou, Anne Tierens, Gunhild Troen, Hege Vangstein Aamot, Sverre Heim, Grete F. Lauritzsen, Helen Vålerhaugen, Jan Delabie

Published in: Virchows Archiv | Issue 1/2006

Abstract

Peripheral T-cell lymphoma (PTCL) with a nodular architecture is rare. Recently, two variants have been described with infiltration of the B-cell follicle, one variant that localizes to the marginal zone with a so-called perifollicular growth pattern, and a variant that localizes to the germinal center. These lymphomas have a CD4+ phenotype and may express Bcl-6. We have studied five similar cases of PTCL with involvement of the B-cell follicle. However, our cases differ from the cases previously described by their predominant and frequently patchy involvement of the expanded mantle zone of the B-cell follicle at onset. Later biopsies in three of the cases show diffuse infiltration of the lymph node, without features of angioimmunoblastic TCL (AILT). All cases expressed Bcl-6 in addition to CD4. Cytogenetics was available in four of the cases but revealed no recurrent chromosomal aberrations or changes associated with other types of PTCL. No mutations of the BCL-6 gene were observed. Together, the cases seem to have an intermediately aggressive clinical behavior. Whether our cases are part of a spectrum of PTCLs that encompasses previously described variants with predominant marginal zone or germinal center infiltration or they represent a separate T-cell lymphoma type remains to be demonstrated by a study of more of such cases.

Abe Y, Choi I, Hara K, Matsushima T, Nishimura J, Inaba S, Nawata H, Muta K (2002) Hemophagocytic syndrome: a rare complication of allogeneic nonmyeloablative hematopoietic stem cell transplantation. Bone Marrow Transplant 29:799–801PubMedCrossRef

Attygalle A, Al-Jehani R, Diss TC, Munson P, Liu H, Du M-Q, Isaacson PG, Dogan A (2002) Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10. Blood 99:627–633PubMedCrossRef

Carbone A, Gloghini A, Gaidano G, Dalla-Favera R, Falini B (1997) BCL-6 protein expression in human peripheral T-cell neoplasms is restricted to CD30+ anaplastic large-cell lymphomas. Blood 90:2445–2450PubMed

Cattoretti G, Chang C-C, Cechova K, Zhang J, Ye BH, Falini B, Louie DC, Offit K, Chaganti RSK, Dalla-Favera R (1995) Bcl-6 protein is expressed in germinal-center B cells. Blood 86:45–53PubMed

Cheynier R, Henrichwark S, Wain-Hobson S (1998) Somatic hypermutation of the T cell receptor Vβ gene in microdissected splenic white pulps from HIV-1-positive patients. Eur J Immunol 28:1604–1610PubMedCrossRef

de Leval L, Savilo E, Longtine J, Ferry JA, Harris NL (2001) Peripheral T-cell lymphoma with follicular involvement and a CD4+/bcl-6+ phenotype. Am J Surg Pathol 25:395–400PubMedCrossRef

Dent AL, Hu-Li J, Paul WE, Staudt LM (1998) T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6. Proc Natl Acad Sci USA 95:13823–13828PubMedCrossRef

Fukuno K, Tsurumi H, Yamada T, Oyama M, Moriwaki H (2001) Graft failure due to hemophagocytic syndrome after autologous peripheral blood stem cell transplantation. Int J Hematol 73:262–265PubMedCrossRef

Golby SJC, Dunn-Walters DK, Spencer J (1999) Human tonsillar germinal center T cells are a diverse and widely disseminated population. Eur J Immunol 29:3729–3736PubMedCrossRef

10.

Greiner TC, Raffeld M, Lutz C, Dick F, Jaffe ES (1995) Analysis of T cell receptor-gamma gene rearrangements by denaturing gradient gel electrophoresis of GC-clamped polymerase chain reaction products. Correlation with tumor-specific sequences. Am J Pathol 146:46–55PubMed

11.

Hsu SM, Raine L, Fanger H (1981) Use of avidin–biotin–peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577–580PubMed

12.

Hyjek E, Chadburn A, Liu YF, Cesarman E, Knowles DM (2001) BCL-6 protein is expressed in precursor T-cell lymphoblastic lymphoma and in prenatal and postnatal thymus. Blood 97:270–276PubMedCrossRef

13.

Jiang L, Jones D, Medeiros LJ, Orduz YR, Bueso-Ramos CE (2005) Peripheral T-cell lymphoma with a “follicular” pattern and the perifollicular sinus phenotype. Am J Clin Pathol 123:448–455PubMedCrossRef

14.

Kerl K, Vonlanthen R, Nagy M, Bolzonello NJ, Gindre P, Hurwitz N, Gudat F, Nador RG, Borisch B (2001) Alterations on the 5′ noncoding region of the BCL-6 gene are not correlated with BCL-6 protein expression in T cell non-Hodgkin lymphomas. Lab Invest 81:1693–1702PubMed

15.

Lepretre S, Buchonnet G, Stamatoullas A, Lenain P, Duval C, d'Anjou J, Callat M-P, Tilly H, Bastard C (2000) Chromosome abnormalities in peripheral T-cell lymphoma. Cancer Genet Cytogenet 117:71–79PubMedCrossRef

16.

Macon WR, Williams ME, Greer JP, Cousar JB (1995) Paracortical nodular T-cell lymphoma. Identification of an unusual variant of peripheral T-cell lymphoma. Am J Surg Pathol 19:297–303PubMedCrossRef

17.

Migliazza A, Martinotti S, Chen W, Fusco C, Ye BH, Knowles DM, Offit K, Chaganti RSK, Dalla-Favera R (1995) Frequent somatic hypermutation of the 5′ noncoding region of the BCL-6 gene in B-cell lymphoma. Proc Natl Acad Sci USA 92:12520–12524PubMedCrossRef

18.

Mitelman F (ed) (1995) An international system for human cytogenetic nomenclature. Karger, Basel

19.

Pasqualucci L, Migliazza A, Fracchiolla N, William C, Neri A, Baldini L, Chaganti RSK, Klein U, Küppers R, Rajewsky K, Dalla-Favera R (1998) BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc Natl Acad Sci USA 95:11816–11821PubMedCrossRef

20.

Rajewsky K (1996) Clonal selection and learning in the antibody system. Nature 27 381(6585):751–758CrossRef

21.

Ree HJ, Kadin ME, Kikuchi M, Ko YH, Go JH, Suzumiya J, Kim DS (1998) Angioimmunoblastic lymphoma (AILD-type T-cell lymphoma) with hyperplastic germinal centers. Am J Surg Pathol 22:643–655PubMedCrossRef

22.

Ree HJ, Kadin ME, Kikuchi M, Ko YH, Suzumiya J, Go JH (1999) Bcl-6 expression in reactive follicular hyperplasia, follicular lymphoma, and angioimmunoblastic T-cell lymphoma with hyperplastic germinal centers: heterogeneity of intrafollicular T-cells and their altered distribution in the pathogenesis of angioimmunoblastic T-cell lymphoma. Hum Pathol 30:403–411PubMedCrossRef

23.

Roers A, Hansmann ML, Rajewsky K, Küppers R (2000) Single-cell PCR analysis of T helper cells in human lymph node germinal centers. Am J Pathol 156:1067–1071PubMed

24.

Rüdiger T, Ichinohasama R, Ott MM, Müller-Deubert S, Miura I, Ott G, Müller-Hermelink HK (2000) Peripheral T-cell lymphoma with distinct perifollicular growth pattern. A distinct subtype of T-cell lymphoma? Am J Surg Pathol 24:117–122PubMedCrossRef

25.

Schlegelberger B, Zhang Y, Weber-Matthiesen K, Grote W (1994) Detection of aberrant clones in nearly all cases of angioimmunoblastic lymphadenopathy with dysproteinemia-type T-cell lymphoma by combined interphase and metaphase cytogenetics. Blood 84:2640–2648PubMed

26.

Smith JL, Hodges E, Quin CT, McCarthy KP, Wright DH (2000) Frequent T and B cell oligoclones in histologically and immunophenotypically characterized angioimmunoblastic lymphadenopathy. Am J Pathol 156:661–669PubMed

27.

van den Oord JJ, de Wolf-Peeters C, O'Connor NTJ, de Vos R, Tricot G, Desmet VJ (1988) Nodular T-cell lymphoma. Report of a case studied with morphologic, immunohistochemical, and DNA hybridization techniques. Arch Pathol Lab Med 112:133–138PubMed

28.

Vega F, Luthra R, Medeiros LJ, Dunmire V, Lee S-J, Duvic M, Jones D (2002) Clonal heterogeneity in mycosis fungoides and its relationship to clinical course. Blood 100:3369–3373PubMedCrossRef

29.

Ye BH, Cattoretti G, Shen Q, Zhang J, Hawe N, de Waard R, Leung C, Nouri-Shirazi M, Orazi A, Chaganti RSK, Rothman P, Stall AM, Pandolfi P-P, Dalla-Favera R (1997) The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet 16:161–170PubMedCrossRef

30.

Zheng B, Xue W, Kelsoe G (1994) Locus-specific somatic hypermutation in germinal centre T cells. Nature 372:556–559PubMedCrossRef

Title: Peripheral T-cell lymphoma with involvement of the expanded mantle zone
Authors: Ida Münster Ikonomou
Anne Tierens
Gunhild Troen
Hege Vangstein Aamot
Sverre Heim
Grete F. Lauritzsen
Helen Vålerhaugen
Jan Delabie
Publication date: 01-07-2006
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 1/2006
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-005-0123-z

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Peripheral T-cell lymphoma with involvement of the expanded mantle zone

Abstract

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Abstract

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