Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Documenta Ophthalmologica
Published in: Documenta Ophthalmologica 1/2015

01-08-2015 | Original Research Article

Peripheral retinal function assessed with 30-Hz flicker seems to improve after treatment with Lucentis in patients with diabetic macular oedema

Authors: Kristina Holm, Marion Schroeder, Monica Lövestam Adrian

Published in: Documenta Ophthalmologica | Issue 1/2015

Login to get access

Abstract

Purpose

To evaluate the influence of ranibizumab on the multifocal electroretinogram (Mf-ERG), full-field electroretinogram (Ff-ERG) and optical coherence tomography (OCT) in diabetic eyes (n = 20) with macular oedema.

Methods

In 20 eyes (20 diabetic subjects) with no or background diabetic retinopathy and macular oedema (age 65.7 ± 9.8 years, duration 16.5 ± 10.0 years), the change in ETDRS letters, Mf-ERG, Ff-ERG and OCT was analysed, at baseline, 4 weeks after the first injection, (just before the second injection), and 4 weeks after the last injection with ranibizumab.

Results

From baseline, mean BCVA improved from 64.0 ± 10.0 ETDRS letters to 75.0 ± 7.3 ETDRS letters (p = 0.005) 1 month after the last injection. Mean OCT thickness reduced after the first injection from 418 ± 117 to 311 ± 126 µm; (p = 0.001) and to 302 ± 74 µm after the third injection. Mf-ERG demonstrated in the innermost three rings a shorter implicit time after the first injection with p values of 0.002, 0.005 and 0.017, respectively. After the third injection, implicit time was prolonged to almost the original levels. Cone implicit time with 30-Hz flicker improved significantly between baseline (35.5 ± 3.6 ms) and final follow-up (34.6 ± 3.1 ms) (p = 0.04).

Discussion

Though the central retinal thickness was reduced after three injections of ranibizumab and the subjects gained a mean of 11 ETDRS letters, there was no significant change in amplitude or implicit time in Mf-ERG. The shortened 30-Hz flicker implicit time might imply that ranibizumab has no negative impact on the entire peripheral cone function, but can improve it instead.
Literature
1.
Moss SE, Klein R, Klein BEK (1988) The incidence of vision loss in a diabetic population. Ophthalmology 95:1340–1348PubMedCrossRef
2.
Early Treatment Diabetic Retinopathy Study Research Group (1985) Photocoagulation for diabetic macular oedema: ETDRS report number 1. Arch Ophthalmol 103:1796–1806CrossRef
3.
Mitchell P, Bandello F, Schmidt-Erfurth U, Lang GE, Massin P, Schlingemann RO, Sutter F, Simader C, Burian G, Gerstner O, Weichselberger A, RESTORE study group (2011) The RESTORE study: Ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema. Ophthalmology 118(4):615–625PubMedCrossRef
4.
Massin P, Bandello F, Garweg JG, Hansen LL, Harding SP, Larsen M, Mitchell P, Sharp D, Wolf-Schnurrbusch UE, Gekkieva M, Weichselberger A, Wolf S (2010) Safety and efficacy of ranibizumab in diabetic macular edema (RESOLVE study): a 12-month, randomized, controlled, double- masked, multicenter phase II study. Diabetes Care 33(11):2399–2405PubMedCentralPubMedCrossRef
5.
Grant MB, Afzal A, Spoerri P, Pan H, Shaw LC, Mames RN (2004) The role of growth factors in the pathogenesis of diabetic retinopathy. Expert Opin Investig Drugs 13(10):1275–1293PubMedCrossRef
6.
Ferrara N (2004) Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 25(4):581–611PubMedCrossRef
7.
Tolentino MJ, Miller JW, Gragoudas ES, Jakobiec FA, Flynn E, Chatzistefanou K, Ferrara N, Adamis AP (1996) Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate. Ophthalmology 103(11):1820–1828PubMedCrossRef
8.
Ip MS, Domalpally A, Hopkins JJ, Wong P, Ehrlich JS (2012) Long-term effects of ranibizumab on diabetic retinopathy severity and progression. Arch Ophthalmol 130(9):1145–1152PubMedCrossRef
9.
Nunes S, Pereira I, Santos A, Bernardes R, Cunha-Vaz J (2010) Central retinal thickness measured with HD-OCT shows a weak correlation with visual acuity in eyes with CSME. Br J Ophthalmol 94(9):1201–1204PubMedCrossRef
10.
Holm K, Larsson J, Lövestam-Adrian M (2007) In diabetic retinopathy, foveal thickness of 300 µm seems to correlate with functionally significant loss of vision. Doc Ophthalmol 114(117–124):14
11.
Alasil T, Keane PA, Updike JF, Dustin L, Ouyang Y, Walsh AC, Sadda SR (2010) Relationship between optical coherence tomography retinal parameters and visual acuity in diabetic macular edema. Ophthalmology 117(12):2379–2386PubMedCrossRef
12.
Marmor MF, Fulton AB, Holder GE, Miyake Y, Brigell M, Bach M (2009) Standard for clinical electroretinography (2008 update). Doc Ophthalmol 118:69–77PubMedCrossRef
13.
Hood DC, Bach M, Brigell M, Keating D, Kondo M, Lyons JS, Marmor MF, McCulloch DL, Palmowski-Wolfe AM (2012) ISCEV standard for clinical multifocal electroretinography (2011 edition). Doc Ophthalmol 124:1–13PubMedCentralPubMedCrossRef
14.
Holm K, Ponjavic V, Lövestam-Adrian M (2010) Using multifocal electroretinography hard exudates affect macular function in eyes with diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 248:1241–1247PubMedCrossRef
15.
Kjeka O, Bredrup C, Krohn J (2007) Photopic 30 Hz flicker electroretinography predicts ocular neovascularization in central retinal vein occlusion. Acta Ophthalmol Scand 85(6):640–643PubMedCrossRef
16.
Larsson J, Bauer B, Andréasson S (2008) The 30-Hz flicker cone ERG for monitoring the early course of central retinal vein occlusion. Doc Ophthalmol 117(2):103–109CrossRef
17.
Gong Y, Wu X, Sun X, Zhang X, Zhu P (2008) Electroretinogram changes after scleral buckling surgery of retinal detachment. Doc Ophthalmol 117(2):103–109PubMedCrossRef
18.
Pedersen KB, Möller F, Sjölie AK, Andréasson S (2010) Electrophysiological assessment of retinal function during 6 months of bevacizumab treatment in neovascular age-related macular degeneration. Retina 30:1025–1033PubMedCrossRef
19.
Comyn O, Sivaprasad S, Peto T, Neveu MM, Holder GE, Xing W, Bunce CV, Patel PJ, Egan CA, Bainbridge JW, Hykin PG (2014) A randomized trial to assess functional and structural effects of ranibizumab versus laser in diabetic macular edema (the LUCIDATE study). Am J Ophthalmol 157:960–970PubMedCrossRef
20.
Schmidt-Erfurth U, Lang GE, Holz FG, Schlingemann RO, Lanzetta P, Massin P, Gerstner O, Bouazza AS, Shen H, Osborne A, Mitchell P; RESTORE Extension Study Group (2014) Three-year outcomes of individualized ranibizumab treatment in patients with diabetic macular edema: the RESTORE extension study. Ophthalmology 121(5):1045–1053CrossRef
21.
Lee JY, Folgar FA, Maguire MG, Ying GS, Toth CA, Martin DF, Jaffe GJ, CATT Research Group (2014) Outer retinal tubulation in the comparison of age-related macular degeneration treatments trials (CATT). Ophthalmology 121(12):2423–2431PubMedCrossRef
22.
Klemp K, Larsen M, Sander B, Vaag A, Brockhoff PB, Lund-Andersen H (2004) Effect of short-term hyperglycemia, on multifocal electroretinogram in diabetic patients without retinopathy. Invest Ophthalmol Vis Sci 45(10):3812–3819PubMedCrossRef
23.
Grunwald JE, Daniel E, Huang J, Ying GS, Maquire MG, Ca Toth, Jaffe GJ, Fine SL, Blodi B, Klein ML, Martin AA, Hagstrom SA, Martin DF, CATT Research Group (2014) Risk of geographic atrophy in the comparison of age-related macular degeneration treatments trials. Ophthalmology 121(1):150–161PubMedCentralPubMedCrossRef
Metadata
Title
Peripheral retinal function assessed with 30-Hz flicker seems to improve after treatment with Lucentis in patients with diabetic macular oedema
Authors
Kristina Holm
Marion Schroeder
Monica Lövestam Adrian
Publication date
01-08-2015
Publisher
Springer Berlin Heidelberg
Published in
Documenta Ophthalmologica / Issue 1/2015
Print ISSN: 0012-4486
Electronic ISSN: 1573-2622
DOI
https://doi.org/10.1007/s10633-015-9495-9

Other articles of this Issue 1/2015

Documenta Ophthalmologica 1/2015 Go to the issue

Clinical Case Report

Reduced rod electroretinograms in carrier parents of two Japanese siblings with autosomal recessive retinitis pigmentosa associated with PDE6B gene mutations

Original Research Article

Aripiprazole-induced chorioretinopathy: multimodal imaging and electrophysiological features

Erratum

Erratum to: ISCEV Standard for full-field clinical electroretinography (2015 update)

Original Research Article

Vigabatrin can enhance electroretinographic responses in pigmented and albino rats

Original Research Article

Relating the steady-state visual evoked potential to single-stimulus responses derived from m-sequence stimulation

Original Research Article

Comparison of human expert and computer-automated systems using magnitude-squared coherence (MSC) and bootstrap distribution statistics for the interpretation of pattern electroretinograms (PERGs) in infants with optic nerve hypoplasia (ONH)