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Published in:

01-09-2013 | Review Article

Peripheral polymorphonuclear leukocyte activation as a systemic inflammatory response in ischemic stroke

Authors: Xiaoye Mo, Ting Li, Guang Ji, Wei Lu, Zhiping Hu

Published in: Neurological Sciences | Issue 9/2013

Abstract

Stroke is one of the leading causes of mortality and morbidity in the world. The activation of polymorphonuclear leukocytes (PMNL) plays an important role in the inflammatory response after ischemic stroke. However, in the current literature, there are few studies discussing the process and role of peripheral PMNL activation. Here, we give a comprehensive description of peripheral PMNL activation after ischemic stroke and discuss their potential roles in the process of ischemic injury. Based on our analysis, peripheral PMNL activation is supposed to be attributed to systemic inflammatory response to cerebral ischemic insult, not reflecting the activity of PMNL in local ischemic brain. Inhibiting peripheral PMNL activation in stroke animals has been effective in reducing infarction and improving behavioral outcome; thus, the same approach of inhibiting peripheral PMNL activation is a promising therapeutic strategy for stroke patients.

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Title: Peripheral polymorphonuclear leukocyte activation as a systemic inflammatory response in ischemic stroke
Authors: Xiaoye Mo
Ting Li
Guang Ji
Wei Lu
Zhiping Hu
Publication date: 01-09-2013
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 9/2013
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-013-1447-0

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Peripheral polymorphonuclear leukocyte activation as a systemic inflammatory response in ischemic stroke

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