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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2013

Open Access 01-12-2013 | Research article

Peripheral endothelial function and arterial stiffness in patients with chronic migraine: a case–control study

Authors: Pedro Enrique Jiménez Caballero, Francisco Muñoz Escudero

Published in: The Journal of Headache and Pain | Issue 1/2013

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Abstract

Background

Migraine is a complex and disabilitating neurovascular disorder predominantly affecting women. There is strong evidence that nitric oxide is critically involved in migraine pathophysiology. The aim of the present study was to test the hypothesis that chronic migraine is associated with ultrasonographic endothelial dysfunction and increase in arterial stiffness. These parameters were assessed using a novel plethysmograph by peripheral arterial tonometry.

Methods

Twenty-one patients with chronic migraine and twenty-one healthy controls matched by sex and gender were recruited. Measurement of the ultrasonographic endothelial function and augmentation index were made according to manufacturer’s protocol.

Results

The mean of patient’s peripheral arterial tonometry ratios was 1.93 ± 0.39 and for healthy control 2.21 ± 0.44 (p = 0.040). The median of patients’ augmentation index was −6,0 (IQR: 6.5 to −15) in healthy controls and 9.0 (IQR: 4 to 12) in chronic migraine, (p = 0.002).

Conclusions

Patients with chronic migraine have ultrasonographic endothelial dysfunction and increase in the arterial stiffness. An improved understanding of the role in the endothelial system of migraine may provide a basis for preventive drugs in migraine and restore the endothelial function.
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Metadata
Title
Peripheral endothelial function and arterial stiffness in patients with chronic migraine: a case–control study
Authors
Pedro Enrique Jiménez Caballero
Francisco Muñoz Escudero
Publication date
01-12-2013
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2013
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/1129-2377-14-8

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