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Published in: Quality of Life Research 8/2019

Open Access 01-08-2019 | Peripheral Arterial Disease

Comparison of three generic quality-of-life metrics in peripheral arterial disease patients undergoing conservative and invasive treatments

Authors: Svenja Petersohn, Bram L. T. Ramaekers, Renske H. Olie, Arina J. ten Cate-Hoek, Jan-Willem H. C. Daemen, Hugo ten Cate, Manuela A. Joore

Published in: Quality of Life Research | Issue 8/2019

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Abstract

Purpose

To determine the effect of revascularisation for peripheral arterial disease (PAD) on QoL in the first and second year following diagnosis, to compare the effect depicted by Short Form Six Dimensions (SF-6D) and EuroQoL five Dimensions (EQ-5D) utilities, and Visual Analogue Scale (VAS) scores and to analyse heterogeneity in treatment response.

Methods

Longitudinal data from 229 PAD patients were obtained in an observational study in southern Netherlands. Utility scores were calculated with the international (SF-6D) and Dutch (EQ-5D) tariffs. We analysed treatment effect at years 1 and 2 through propensity score-matched ANCOVAs. Thereby, we estimated the marginal means (EMMs) of revascularisation and conservative treatment, and identified covariates of revascularisation effect.

Results

A year after diagnosis, 70 patients had been revascularised; the EMMs of revascularisation were 0.038, 0.077 and 0.019 for SF-6D, EQ-5D and VAS, respectively (always in this order). For conservative treatment these were − 0.017, 0.038 and 0.021. At 2-year follow-up, the EMMs of revascularisation were 0.015, 0.077 and 0.027, for conservative treatment these were − 0.020, 0.013 and − 0.004. Baseline QoL (and rest pain in year 2) were covariates of treatment effect.

Conclusions

We measured positive effects of revascularisation and conservative treatment on QoL a year after diagnosis, the effect of revascularisation was sustained over 2 years. The magnitude of effect varied between the metrics and was largest for the EQ-5D, which may be most suitable for QoL measurement in PAD patients. Baseline QoL influenced revascularisation effect, in clinical practice this may inform expected QoL gain in individual patients.
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Metadata
Title
Comparison of three generic quality-of-life metrics in peripheral arterial disease patients undergoing conservative and invasive treatments
Authors
Svenja Petersohn
Bram L. T. Ramaekers
Renske H. Olie
Arina J. ten Cate-Hoek
Jan-Willem H. C. Daemen
Hugo ten Cate
Manuela A. Joore
Publication date
01-08-2019
Publisher
Springer International Publishing
Published in
Quality of Life Research / Issue 8/2019
Print ISSN: 0962-9343
Electronic ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-019-02166-0

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