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Published in: Obesity Surgery 10/2015

Open Access 01-10-2015 | Original Contributions

Perioperative Outcomes of Proximal and Distal Gastric Bypass in Patients with BMI Ranged 50–60 kg/m2—A Double-Blind, Randomized Controlled Trial

Authors: Marius Svanevik, Hilde Risstad, Dag Hofsø, Carl Fredrik Schou, Brita Solheim, Torgeir T. Søvik, Jon Kristinsson, Jøran Hjelmesæth, Tom Mala, Rune Sandbu

Published in: Obesity Surgery | Issue 10/2015

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Abstract

Background

Proximal Roux-en-Y gastric bypass may not ensure adequate weight loss in superobese patients. Bypassing a longer segment of the small bowel may increase weight loss. The objective of the study was to compare the perioperative outcomes of laparoscopic proximal and distal gastric bypass in a double-blind randomized controlled trial of superobese patients. The study was conducted at two public tertiary care obesity centers in Norway.

Methods

Patients with body mass index (BMI) 50–60 kg/m2 were randomly assigned to a proximal (150 cm alimentary limb) or a distal (150 cm common channel) gastric bypass. The biliopancreatic limb was 50 cm in both operations. Patients and follow-up personnel were blinded to the type of procedure. Thirty-day outcomes including complications are reported.

Results

We operated on 115 patients, of whom two were excluded at surgery, leaving 56 and 57 patients in the proximal group and distal group, respectively. The median (range) operating time was 72 (36–151) and 101 (59–227) min, respectively (p < 0.001). Two distal procedures were converted to laparotomy during the primary procedure. Median length of hospital stay was 2 (1–4) days in the proximal group and 2 (1–24) days in the distal group. The number of patients with complications and complications categorized according to the Contracted Accordion classification did not differ significantly. However, all six reoperations were performed in the distal group, of which three were completed by laparoscopy (p = 0.01 between groups). There were no deaths.

Conclusions

In superobese patients with BMI between 50 and 60 kg/m2, distal gastric bypass was associated with longer operating time and more severe complications resulting in reoperation than proximal gastric bypass.
Literature
1.
go back to reference Thivel D, Brakonieki K, Duche P, et al. Surgical weight loss: impact on energy expenditure. Obes Surg. 2012;23:255–66.CrossRef Thivel D, Brakonieki K, Duche P, et al. Surgical weight loss: impact on energy expenditure. Obes Surg. 2012;23:255–66.CrossRef
2.
go back to reference Borg CM, le Roux CW, Ghatei MA, et al. Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety. Br J Surg. 2006;93:210–5.CrossRefPubMed Borg CM, le Roux CW, Ghatei MA, et al. Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety. Br J Surg. 2006;93:210–5.CrossRefPubMed
3.
4.
go back to reference Hofsø D, Nordstrand N, Johnson LK, et al. Obesity-related cardiovascular risk factors after weight loss: a clinical trial comparing gastric bypass surgery and intensive lifestyle intervention. Eur J Endocrinol. 2010;163:735–45.PubMedCentralCrossRefPubMed Hofsø D, Nordstrand N, Johnson LK, et al. Obesity-related cardiovascular risk factors after weight loss: a clinical trial comparing gastric bypass surgery and intensive lifestyle intervention. Eur J Endocrinol. 2010;163:735–45.PubMedCentralCrossRefPubMed
5.
go back to reference Christou NV, Look D, MacLean LD. Weight gain after short- and long-limb gastric bypass in patients followed for longer than 10 years. Ann Surg. 2006;244:734–40.PubMedCentralCrossRefPubMed Christou NV, Look D, MacLean LD. Weight gain after short- and long-limb gastric bypass in patients followed for longer than 10 years. Ann Surg. 2006;244:734–40.PubMedCentralCrossRefPubMed
6.
go back to reference Suter M. Results of Roux-en-Y gastric bypass in morbidly obese vs superobese patients. Arch Surg. 2009;144:1–7.CrossRef Suter M. Results of Roux-en-Y gastric bypass in morbidly obese vs superobese patients. Arch Surg. 2009;144:1–7.CrossRef
7.
go back to reference Risstad H, Søvik TT, Engström M, et al. Five-year outcomes after laparoscopic gastric bypass and laparoscopic duodenal switch in patients with body mass index of 50 to 60: a randomized clinical trial. JAMA Surg. 2015. doi:10.1001/jamasurg.2014.3579.PubMed Risstad H, Søvik TT, Engström M, et al. Five-year outcomes after laparoscopic gastric bypass and laparoscopic duodenal switch in patients with body mass index of 50 to 60: a randomized clinical trial. JAMA Surg. 2015. doi:10.​1001/​jamasurg.​2014.​3579.PubMed
8.
go back to reference Hedberg J, Sundström J, Sundbom M. Duodenal switch versus Roux-en-Y gastric bypass for morbid obesity: systematic review and meta-analysis of weight results, diabetes resolution and early complications in single-centre comparisons. Obes Rev. 2014;15:555–63.CrossRefPubMed Hedberg J, Sundström J, Sundbom M. Duodenal switch versus Roux-en-Y gastric bypass for morbid obesity: systematic review and meta-analysis of weight results, diabetes resolution and early complications in single-centre comparisons. Obes Rev. 2014;15:555–63.CrossRefPubMed
9.
go back to reference Madan AK, Harper JL, Tichansky DS. Techniques of laparoscopic gastric bypass: on-line survey of American Society for Bariatric Surgery practicing surgeons. Surg Obes Relat Dis. 2008;4:166–72.CrossRefPubMed Madan AK, Harper JL, Tichansky DS. Techniques of laparoscopic gastric bypass: on-line survey of American Society for Bariatric Surgery practicing surgeons. Surg Obes Relat Dis. 2008;4:166–72.CrossRefPubMed
10.
go back to reference Stefandis D, Kuwada TS, Gersin KS. The importance of the length of the limbs for gastric bypass patients—an evidence-based review. Obes Surg. 2011;21:119–24.CrossRef Stefandis D, Kuwada TS, Gersin KS. The importance of the length of the limbs for gastric bypass patients—an evidence-based review. Obes Surg. 2011;21:119–24.CrossRef
11.
go back to reference Brolin RE, LaMarca LB, Kenler HA, et al. Malabsorptive gastric bypass in patients with superobesity. J Gastrointest Surg. 2002;6:195–203. discussion 204–5.CrossRefPubMed Brolin RE, LaMarca LB, Kenler HA, et al. Malabsorptive gastric bypass in patients with superobesity. J Gastrointest Surg. 2002;6:195–203. discussion 204–5.CrossRefPubMed
12.
go back to reference Sugerman HF, Kellum JM, DeMaria EJ. Conversion of proximal to distal gastric bypass for failed gastric bypass for superobesity. J Gastrointest Surg. 1997;1:517–24. discussion 524–6.CrossRefPubMed Sugerman HF, Kellum JM, DeMaria EJ. Conversion of proximal to distal gastric bypass for failed gastric bypass for superobesity. J Gastrointest Surg. 1997;1:517–24. discussion 524–6.CrossRefPubMed
13.
go back to reference Nelson WK, Fatima J, Houghton SG, et al. The malabsorptive very, very long limb Roux-en-Y gastric bypass for super obesity: results in 257 patients. Surgery. 2006;140:517–23.CrossRefPubMed Nelson WK, Fatima J, Houghton SG, et al. The malabsorptive very, very long limb Roux-en-Y gastric bypass for super obesity: results in 257 patients. Surgery. 2006;140:517–23.CrossRefPubMed
14.
go back to reference American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37 Suppl 1:S81–90.CrossRef American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37 Suppl 1:S81–90.CrossRef
15.
go back to reference James PA, Oparil S, Carter BL, et al. 2014 evidence-based guideline for the management of high blood pressure in adults. JAMA. 2014;311:507.CrossRefPubMed James PA, Oparil S, Carter BL, et al. 2014 evidence-based guideline for the management of high blood pressure in adults. JAMA. 2014;311:507.CrossRefPubMed
16.
go back to reference Lönroth H, Dalenbäck J, Haglind E, et al. Laparoscopic gastric bypass. Another option in bariatric surgery. Surg Endosc. 1996;10:636–8.CrossRefPubMed Lönroth H, Dalenbäck J, Haglind E, et al. Laparoscopic gastric bypass. Another option in bariatric surgery. Surg Endosc. 1996;10:636–8.CrossRefPubMed
17.
go back to reference Strasberg SM, Linehan DC, Hawkins WG. The accordion severity grading system of surgical complications. Ann Surg. 2009;250:177–86.CrossRefPubMed Strasberg SM, Linehan DC, Hawkins WG. The accordion severity grading system of surgical complications. Ann Surg. 2009;250:177–86.CrossRefPubMed
18.
go back to reference Parikh MS, Shen R, Weiner M, et al. Laparoscopic bariatric surgery in super-obese patients (BMI > 50) is safe and effective: a review of 332 patients. Obes Surg. 2005;15:858–63.CrossRefPubMed Parikh MS, Shen R, Weiner M, et al. Laparoscopic bariatric surgery in super-obese patients (BMI > 50) is safe and effective: a review of 332 patients. Obes Surg. 2005;15:858–63.CrossRefPubMed
19.
go back to reference Thurnheer M, Bisang P, Ernst B, et al. A novel distal very long Roux-en Y gastric bypass (DVLRYGB) as a primary bariatric procedure—complication rates, weight loss, and nutritional/metabolic changes in the first 355 patients. Obes Surg. 2012;22:1427–36.CrossRefPubMed Thurnheer M, Bisang P, Ernst B, et al. A novel distal very long Roux-en Y gastric bypass (DVLRYGB) as a primary bariatric procedure—complication rates, weight loss, and nutritional/metabolic changes in the first 355 patients. Obes Surg. 2012;22:1427–36.CrossRefPubMed
20.
go back to reference Müller MK, Räder S, Wildi S, et al. Long-term follow-up of proximal versus distal laparoscopic gastric bypass for morbid obesity. Br J Surg. 2008;95:1375–9.CrossRefPubMed Müller MK, Räder S, Wildi S, et al. Long-term follow-up of proximal versus distal laparoscopic gastric bypass for morbid obesity. Br J Surg. 2008;95:1375–9.CrossRefPubMed
21.
22.
go back to reference Choban PS, Flancbaum L. The effect of Roux limb lengths on outcome after Roux-en-Y gastric bypass: a prospective, randomized clinical trial. Obes Surg. 2002;12:540–5.CrossRefPubMed Choban PS, Flancbaum L. The effect of Roux limb lengths on outcome after Roux-en-Y gastric bypass: a prospective, randomized clinical trial. Obes Surg. 2002;12:540–5.CrossRefPubMed
23.
go back to reference Inabnet WB, Quinn T, Gagner M, et al. Laparoscopic Roux-en-Y gastric bypass in patients with BMI. Obes Surg. 2005;15:51–7.CrossRefPubMed Inabnet WB, Quinn T, Gagner M, et al. Laparoscopic Roux-en-Y gastric bypass in patients with BMI. Obes Surg. 2005;15:51–7.CrossRefPubMed
24.
go back to reference Pinheiro JS, Schiavon CA, Pereira PB, et al. Long-long limb Roux-en-Y gastric bypass is more efficacious in treatment of type 2 diabetes and lipid disorders in super-obese patients. Surg Obes Relat Dis. 2008;4:521–5.CrossRefPubMed Pinheiro JS, Schiavon CA, Pereira PB, et al. Long-long limb Roux-en-Y gastric bypass is more efficacious in treatment of type 2 diabetes and lipid disorders in super-obese patients. Surg Obes Relat Dis. 2008;4:521–5.CrossRefPubMed
25.
go back to reference Nergaard BJ, Leifsson BG, Hedenbro J, et al. Gastric bypass with long alimentary limb or long pancreato-biliary limb—long-term results on weight loss, resolution of co-morbidities and metabolic parameters. Obes Surg. 2014. Nergaard BJ, Leifsson BG, Hedenbro J, et al. Gastric bypass with long alimentary limb or long pancreato-biliary limb—long-term results on weight loss, resolution of co-morbidities and metabolic parameters. Obes Surg. 2014.
26.
go back to reference Freeman JB, Kotlarewsky M, Phoenix C. Weight loss after extended gastric bypass. Obes Surg. 1997;7:337–44.CrossRefPubMed Freeman JB, Kotlarewsky M, Phoenix C. Weight loss after extended gastric bypass. Obes Surg. 1997;7:337–44.CrossRefPubMed
27.
go back to reference Ciovica R, Takata M, Vittinghoff E, et al. The impact of roux limb length on weight loss after gastric bypass. Obes Surg. 2007;18:5–10.CrossRefPubMed Ciovica R, Takata M, Vittinghoff E, et al. The impact of roux limb length on weight loss after gastric bypass. Obes Surg. 2007;18:5–10.CrossRefPubMed
28.
go back to reference Buchwald H, Kellogg TA, Leslie DB, et al. Duodenal switch operative mortality and morbidity are not impacted by body mass index. Ann Surg. 2008;248:541–8.PubMed Buchwald H, Kellogg TA, Leslie DB, et al. Duodenal switch operative mortality and morbidity are not impacted by body mass index. Ann Surg. 2008;248:541–8.PubMed
29.
go back to reference Søvik TT, Taha O, Aasheim ET, et al. Randomized clinical trial of laparoscopic gastric bypass versus laparoscopic duodenal switch for superobesity. Br J Surg. 2009;97:160–6.CrossRef Søvik TT, Taha O, Aasheim ET, et al. Randomized clinical trial of laparoscopic gastric bypass versus laparoscopic duodenal switch for superobesity. Br J Surg. 2009;97:160–6.CrossRef
30.
go back to reference Kellum JM, Chikunguwo SM, Maher JW, et al. Long-term results of malabsorptive distal Roux-en-Y gastric bypass in superobese patients. Surg Obes Relat Dis. 2011;7:189–93.CrossRefPubMed Kellum JM, Chikunguwo SM, Maher JW, et al. Long-term results of malabsorptive distal Roux-en-Y gastric bypass in superobese patients. Surg Obes Relat Dis. 2011;7:189–93.CrossRefPubMed
31.
go back to reference Birkmeyer JD, Finks JF, O’Reilly A, et al. Surgical skill and complication rates after bariatric surgery. N Engl J Med. 2013;369:1434–42.CrossRefPubMed Birkmeyer JD, Finks JF, O’Reilly A, et al. Surgical skill and complication rates after bariatric surgery. N Engl J Med. 2013;369:1434–42.CrossRefPubMed
32.
go back to reference Cook D, Thompson JE, Habermann EB, et al. From “Solution Shop” model to “Focused Factory” in hospital surgery: increasing care value and predictability. Health Aff. 2014;33:746–55.CrossRef Cook D, Thompson JE, Habermann EB, et al. From “Solution Shop” model to “Focused Factory” in hospital surgery: increasing care value and predictability. Health Aff. 2014;33:746–55.CrossRef
Metadata
Title
Perioperative Outcomes of Proximal and Distal Gastric Bypass in Patients with BMI Ranged 50–60 kg/m2—A Double-Blind, Randomized Controlled Trial
Authors
Marius Svanevik
Hilde Risstad
Dag Hofsø
Carl Fredrik Schou
Brita Solheim
Torgeir T. Søvik
Jon Kristinsson
Jøran Hjelmesæth
Tom Mala
Rune Sandbu
Publication date
01-10-2015
Publisher
Springer US
Published in
Obesity Surgery / Issue 10/2015
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-015-1621-y

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