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01-02-2021 | Periodontal Treatment | Review

Association between periodontitis and pulse wave velocity: a systematic review and meta-analysis

Authors: Christelle Darnaud, Alexandre Courtet, Audrey Schmitt, Pierre Boutouyrie, Philippe Bouchard, Maria Clotilde Carra

Published in: Clinical Oral Investigations | Issue 2/2021

Abstract

Objectives

Severe periodontitis has been associated with endothelial dysfunction and arterial stiffness. The present study aimed to provide a critical appraisal and a meta-analysis of the literature investigating pulse wave velocity (PWV) in patients with and without severe periodontitis and to assess whether treatments influence PWV.

Materials and methods

English literature was searched on multiple databases up to April 2020 by two independent reviewers. Studies comparing PWV between patients with and without severe periodontitis or assessing the impact of periodontal treatments on PWV were searched and retrieved. Pool data analyses with random effect models were performed. The risk of bias was assessed using Newcastle–Ottawa Scale and RoB2 tools.

Results

Seventeen studies were selected. Of these, 10 were used for the meta-analysis. Twelve were cross-sectional studies and 5 interventional studies, including 3176 patients, of whom 1894 had severe periodontitis and 1282 were considered as the controls (without severe periodontitis). Based on carotid–femoral PWV measurement, patients with severe periodontitis (n = 309) have a significantly higher PVW than patients with non-severe periodontitis (n = 213), with a mean difference of 0.84 m/s (95% CI 0.50–1.18; p < 0.0001; I² = 5%). Similarly, carotid–radial or brachial–ankle PWV values were significantly higher in patients with severe periodontitis. Results concerning the effect of non-surgical periodontal therapy were not conclusive. Overall, 9 studies (53%) were classified at a low risk of bias.

Conclusions

The present study demonstrates that patients with severe periodontitis have higher PWV compared to patients with non-severe periodontitis.

Clinical significance

Severe periodontitis is associated with arterial stiffness, supporting the mutual involvement of dentists and physicians.

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Title: Association between periodontitis and pulse wave velocity: a systematic review and meta-analysis
Authors: Christelle Darnaud
Alexandre Courtet
Audrey Schmitt
Pierre Boutouyrie
Philippe Bouchard
Maria Clotilde Carra
Publication date: 01-02-2021
Publisher: Springer Berlin Heidelberg
Keywords: Periodontal Treatment
Bleeding on Probing
Published in: Clinical Oral Investigations / Issue 2/2021
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-020-03718-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association between periodontitis and pulse wave velocity: a systematic review and meta-analysis

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical significance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical significance

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