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Cancer Causes & Control

Published in:

01-07-2013 | Original paper

Periodontal disease and mouthwash use are risk factors for head and neck squamous cell carcinoma

Authors: Melissa N. Eliot, Dominique S. Michaud, Scott M. Langevin, Michael D. McClean, Karl T. Kelsey

Published in: Cancer Causes & Control | Issue 7/2013

Abstract

Purpose

The purpose of this study was to examine associations between oral hygiene, including history of periodontal disease and mouthwash use, and risk of head and neck squamous cell carcinoma (HNSCC).

Methods

We measured history of oral hygiene and dental care on 513 HNSCC cases and 567 controls from a population-based study of HNSCC. Logistic regression was used to estimate odds ratios (ORs) and 95 % confidence intervals (95 % CI).

Results

Periodontal disease was associated with a slightly elevated risk of HNSCC (OR = 1.09, 95 % CI: 1.02, 1.16). Using any type of mouthwash at least once per day was associated with increased risk compared to never using mouthwash (OR = 1.11, 95 % CI: 1.02, 1.20). HNSCC was associated with frequent use of non-alcoholic mouthwash compared to using any kind of mouthwash rarely or never (OR = 1.24, 95 % CI: 1.05, 1.47).

Conclusions

Our results support an association between periodontal disease and HNSCC. Our data suggest that mouthwash use is associated with HNSCC, but we noted no difference between the effects of alcohol-containing and non-alcoholic mouthwashes.

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Title: Periodontal disease and mouthwash use are risk factors for head and neck squamous cell carcinoma
Authors: Melissa N. Eliot
Dominique S. Michaud
Scott M. Langevin
Michael D. McClean
Karl T. Kelsey
Publication date: 01-07-2013
Publisher: Springer Netherlands
Published in: Cancer Causes & Control / Issue 7/2013
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-013-0209-x

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Abstract

Purpose

Methods

Results

Conclusions

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