Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ASCO Annual Meeting 2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

2024 ASCO Annual Meeting

Keep up to date with all the top stories and latest evidence with our hub page, including official congress videos and expert takeaways.
ADVANCED SEARCH
Log in
Top
BMC Pediatrics
Published in: BMC Pediatrics 1/2014

Open Access 01-12-2014 | Research article

Perinatal mortality in pregnancies with omphalocele: data from the Chinese national birth defects monitoring network, 1996–2006

Authors: Kui Deng, Jie Qiu, Li Dai, Ling Yi, Changfei Deng, Yi Mu, Jun Zhu

Published in: BMC Pediatrics | Issue 1/2014

Login to get access

Abstract

Background

Previous studies on the mortality rate of omphalocele are limited. The risk of death of non-isolated omphalocele and that of cases of omphalocele that are diagnosed prenatally by ultrasound are unclear. This study aimed to estimate the perinatal mortality of pregnancies with omphalocele. This study also examined the potential risk of death of non-isolated omphalocele and that of cases that are prenatally diagnosed by ultrasound.

Methods

Data were retrieved from the national birth defects registry in China, for 1996–2006. Multinomial logistic regression was used to calculate the adjusted odds ratios (AORs) and 95% confidence intervals (CIs) between perinatal mortality and selected maternal and fetal characteristics.

Results

Among 827 cases of omphalocele, 309 (37.4%) cases resulted in termination of pregnancy and stillbirth, and 124 (15.0%) cases resulted in death in the first 7 days after delivery, yielding a perinatal mortality rate of 52.4% (95% CI: 49.0–55.8%). The late fetal death rate (LFDR) of omphalocele that was diagnosed prenatally by ultrasound was 15.91-fold (AOR: 15.91, 95% CI: 10.18–24.87) higher than that of postnatally diagnosed cases. The LFDR of non-isolated omphalocele was 2.64-fold (AOR: 2.64, 95% CI: 1.62–4.29) higher than that of isolated cases. For the early neonatal death rate, neonates with non-isolated omphalocele had a 2.96-fold (AOR: 2.96, 95% CI: 1.82–4.81) higher risk than isolated cases, but the difference between prenatal ultrasound diagnosis and postnatal diagnosis was not significant.

Conclusions

Selected fetal characteristics are significantly associated with the perinatal risk of death from omphalocele. Our findings suggest that improving pregnancy and delivery care, as well as management for omphalocele are important.
Literature
1.
2.
Wilson RD, Johnson MP: Congenital abdominal wall defects: an update. Fetal Diagn Ther. 2004, 19 (5): 385-398.CrossRefPubMed
3.
Calzolari E, Bianchi F, Dolk H, Milan M, EUROCAT Working Group: Omphalocele and gastroschisis in Europe: a survey of 3 million births 1980-1990. Am J Med Genet. 1995, 58 (2): 187-194.CrossRefPubMed
4.
Byron-Scott R, Haan E, Chan A, Bower C, Scott H, Clark K: A population-based study of abdominal wall defects in South Australia and Western Australia. Paediatr Perinat Epidemiol. 1998, 12 (2): 136-151.CrossRefPubMed
5.
Forrester MB, Merz RD: Epidemiology of abdominal wall defects, Hawaii, 1986-1997. Teratology. 1999, 60 (3): 117-123.CrossRefPubMed
6.
Rankin J, Dillon E, Wright C: Congenital anterior abdominal wall defects in the north of England, 1986-1996: occurrence and outcome. Prenat Diagn. 1999, 19 (7): 662-668.CrossRefPubMed
7.
Suita S, Okamatsu T, Yamamoto T, Handa N, Nirasawa Y, Watanabe Y, Yanagihara J, Nishijima E, Hirobe S, Nio M, Gomi A, Horisawa M: Changing profile of abdominal wall defects in Japan: results of a national survey. J Pediatr Surg. 2000, 35 (1): 66-71. discussion 72CrossRefPubMed
8.
Salihu HM, Pierre-Louis BJ, Druschel CM, Kirby RS: Omphalocele and gastroschisis in the State of New York, 1992-1999. Birth Defects Res A Clin Mol Teratol. 2003, 67 (9): 630-636.CrossRefPubMed
9.
Tan KB, Tan KH, Chew SK, Yeo GS: Gastroschisis and omphalocele in Singapore: a ten-year series from 1993 to 2002. Singapore Med J. 2008, 49 (1): 31-36.PubMed
10.
Zhou GX, Liang J, Zhu J, Dai L, Wang YP, Miao L: An epidemiological study on omphalocele in China during 1996 to 2000. Zhonghua Yu Fang Yi Xue Za Zhi. 2004, 38 (5): 328-330.PubMed
11.
Kominiarek MA, Zork N, Pierce SM, Zollinger T: Perinatal outcome in the live-born infant with prenatally diagnosed omphalocele. Am J Perinatol. 2011, 28 (8): 627-634.CrossRefPubMedPubMedCentral
12.
Brantberg A, Blaas HG, Haugen SE, Eik-Nes SH: Characteristics and outcome of 90 cases of fetal omphalocele. Ultrasound Obstet Gynecol. 2005, 26 (5): 527-537.CrossRefPubMed
13.
Boyd PA, Bhattacharjee A, Gould S, Manning N, Chamberlain P: Outcome of prenatally diagnosed anterior abdominal wall defects. Arch Dis Child Fetal Neonatal Ed. 1998, 78 (3): F209-F213.CrossRefPubMedPubMedCentral
14.
Lakasing L, Cicero S, Davenport M, Patel S, Nicolaides KH: Current outcome of antenatally diagnosed exomphalos: an 11 year review. J Pediatr Surg. 2006, 41 (8): 1403-1406.CrossRefPubMed
15.
Sermer M, Benzie RJ, Pitson L, Carr M, Skidmore M: Prenatal diagnosis and management of congenital defects of the anterior abdominal wall. Am J Obstet Gynecol. 1987, 156 (2): 308-312.CrossRefPubMed
16.
Christison-Lagay ER, Kelleher CM, Langer JC: Neonatal abdominal wall defects. Semin Fetal Neonatal Med. 2011, 16 (3): 164-172.CrossRefPubMed
17.
Mitanchez D, Walter-Nicolet E, Humblot A, Rousseau V, Revillon Y, Hubert P: Neonatal care in patients with giant ompholocele: arduous management but favorable outcomes. J Pediatr Surg. 2010, 45 (8): 1727-1733.CrossRefPubMed
18.
Islam S: Clinical care outcomes in abdominal wall defects. Curr Opin Pediatr. 2008, 20 (3): 305-310.CrossRefPubMed
19.
Garne E, Loane M, Dolk H, Group EW: Gastrointestinal malformations: impact of prenatal diagnosis on gestational age at birth. Paediatr Perinat Epidemiol. 2007, 21 (4): 370-375.CrossRefPubMed
20.
Cohen-Overbeek TE, Tong WH, Hatzmann TR, Wilms JF, Govaerts LC, Galjaard RJ, Steegers EA, Hop WC, Wladimiroff JW, Tibboel D: Omphalocele: comparison of outcome following prenatal or postnatal diagnosis. Ultrasound Obstet Gynecol. 2010, 36 (6): 687-692.CrossRefPubMed
21.
Dai L, Zhu J, Liang J, Wang YP, Wang H, Mao M: Birth defects surveillance in China. World J Pediatr. 2011, 7 (4): 302-310.CrossRefPubMed
22.
23.
Stoll C, Alembik Y, Dott B, Roth MP: Risk factors in congenital abdominal wall defects (omphalocele and gastroschisi): a study in a series of 265,858 consecutive births. Ann Genet. 2001, 44 (4): 201-208.CrossRefPubMed
24.
Barisic I, Clementi M, Hausler M, Gjergja R, Kern J, Stoll C: Evaluation of prenatal ultrasound diagnosis of fetal abdominal wall defects by 19 European registries. Ultrasound Obstet Gynecol. 2001, 18 (4): 309-316.CrossRefPubMed
25.
Heider AL, Strauss RA, Kuller JA: Omphalocele: clinical outcomes in cases with normal karyotypes. Am J Obstet Gynecol. 2004, 190 (1): 135-141.CrossRefPubMed
26.
Mann S, Blinman TA, Douglas Wilson R: Prenatal and postnatal management of omphalocele. Prenat Diagn. 2008, 28 (7): 626-632.CrossRefPubMed
27.
Paidas MJ, Crombleholme TM, Robertson FM: Prenatal diagnosis and management of the fetus with an abdominal wall defect. Semin Perinatol. 1994, 18 (3): 196-214.PubMed
28.
Stoll C, Tenconi R, Clementi M: Detection of congenital anomalies by fetal ultrasonographic examination across Europe. Community Genet. 2001, 4 (4): 225-232.PubMed
Metadata
Title
Perinatal mortality in pregnancies with omphalocele: data from the Chinese national birth defects monitoring network, 1996–2006
Authors
Kui Deng
Jie Qiu
Li Dai
Ling Yi
Changfei Deng
Yi Mu
Jun Zhu
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2014
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/1471-2431-14-160

Other articles of this Issue 1/2014

BMC Pediatrics 1/2014 Go to the issue

Research article

Too many crying babies: a systematic review of pain management practices during immunizations on YouTube

Case report

Mandibuloacral dysplasia type A-associated progeria caused by homozygous LMNA mutation in a family from Southern China

Research article

Variation in classification of live birth with newborn period death versus fetal death at the local level may impact reported infant mortality rate

Research article

An evaluation of enteral nutrition practices and nutritional provision in children during the entire length of stay in critical care

Research article

Extending World Health Organization weight-for-age reference curves to older children

Reviewer acknowledgement

Reviewer acknowledgement 2013