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Published in: Archives of Orthopaedic and Trauma Surgery 11/2013

01-11-2013 | Hip Arthroplasty

Periarticular infiltration for pain relief after total hip arthroplasty: a comparison with epidural and PCA analgesia

Authors: Ageliki Pandazi, Ilias Kanellopoulos, Konstantinos Kalimeris, Chrysanthi Batistaki, Nikolaos Nikolakopoulos, Paraskevi Matsota, George C. Babis, Georgia Kostopanagiotou

Published in: Archives of Orthopaedic and Trauma Surgery | Issue 11/2013

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Abstract

Purpose

Epidural and intravenous patient-controlled analgesia (PCA) are established methods for pain relief after total hip arthroplasty (THA). Periarticular infiltration is an alternative method that is gaining ground due to its simplicity and safety. Our study aims to assess the efficacy of periarticular infiltration in pain relief after THA.

Methods

Sixty-three patients undergoing THA under spinal anaesthesia were randomly assigned to receive postoperative analgesia with continuous epidural infusion with ropivacaine (epidural group), intraoperative periarticular infiltration with ropivacaine, clonidine, morphine, epinephrine and corticosteroids (infiltration group) or PCA with morphine (PCA group). PCA morphine provided rescue analgesia in all groups. We recorded morphine consumption, visual analog scale (VAS) scores at rest and movement, blood loss from wound drainage, mean arterial pressure (MAP) and adverse effects at 1, 6, 12, 24 h postoperatively.

Results

Morphine consumption at all time points, VAS scores at rest, 6, 12 and 24 h and at movement, 6 and 12 h postoperatively were lower in infiltration group compared to PCA group (p < 0.05), but did not differ between infiltration and epidural group. There was no difference in adverse events in all groups. At 24 h, MAP was higher in the PCA group (p < 0.05) and blood loss was lower in the infiltration group (p < 0.05).

Conclusions

In our study periarticular infiltration was clearly superior to PCA with morphine after THA, providing better pain relief and lower opioid consumption postoperatively. Infiltration seems to be equally effective to epidural analgesia without having the potential side effects of the latter.
Literature
1.
go back to reference Skinner HB (2004) Multimodal acute pain management. Am J Orthop (Belle Mead NJ) 33(5 Suppl):5–9 Skinner HB (2004) Multimodal acute pain management. Am J Orthop (Belle Mead NJ) 33(5 Suppl):5–9
2.
go back to reference Strassels SA, Chen C, Carr DB (2002) Postoperative analgesia: economics, resource use, and patient satisfaction in an urban teaching hospital. Anesth Analg 94:130–137PubMed Strassels SA, Chen C, Carr DB (2002) Postoperative analgesia: economics, resource use, and patient satisfaction in an urban teaching hospital. Anesth Analg 94:130–137PubMed
3.
go back to reference Frater RA, Moores MA, Parry P, Hanning CD (1989) Analgesia-induced respiratory depression: comparison of meptazinol and morphine in the postoperative period. Br J Anaesth 63:260–265PubMedCrossRef Frater RA, Moores MA, Parry P, Hanning CD (1989) Analgesia-induced respiratory depression: comparison of meptazinol and morphine in the postoperative period. Br J Anaesth 63:260–265PubMedCrossRef
4.
go back to reference Tang R, Evans H, Chaput A, Klim C (2009) Multimodal analgesia for hip arthroplasty. Orthop Clin North Am 40:377–387PubMedCrossRef Tang R, Evans H, Chaput A, Klim C (2009) Multimodal analgesia for hip arthroplasty. Orthop Clin North Am 40:377–387PubMedCrossRef
5.
go back to reference Newsome LT, Weller RS, Gerancher JC, Kutcher MA, Royster RL (2008) Coronary artery stents: II. Perioperative considerations and management. Anesth Analg 107:570–590PubMedCrossRef Newsome LT, Weller RS, Gerancher JC, Kutcher MA, Royster RL (2008) Coronary artery stents: II. Perioperative considerations and management. Anesth Analg 107:570–590PubMedCrossRef
6.
go back to reference Hebl JR, Kopp SL, Ali MH, Horlocker TT, Dilger JA, Lennon RL et al (2005) A comprehensive anesthesia protocol that emphasizes peripheral nerve blockade for total knee and total hip arthroplasty. J Bone Joint Surg Am 87(Suppl 2):63–70PubMedCrossRef Hebl JR, Kopp SL, Ali MH, Horlocker TT, Dilger JA, Lennon RL et al (2005) A comprehensive anesthesia protocol that emphasizes peripheral nerve blockade for total knee and total hip arthroplasty. J Bone Joint Surg Am 87(Suppl 2):63–70PubMedCrossRef
7.
go back to reference Essving P, Axelsson K, Kjellberg J, Wallgren O, Gupta A, Lundin A (2009) Reduced hospital stay, morphine consumption, and pain intensity with local infiltration analgesia after unicompartmental knee arthroplasty. Acta Orthop 80:213–219PubMedCrossRef Essving P, Axelsson K, Kjellberg J, Wallgren O, Gupta A, Lundin A (2009) Reduced hospital stay, morphine consumption, and pain intensity with local infiltration analgesia after unicompartmental knee arthroplasty. Acta Orthop 80:213–219PubMedCrossRef
8.
go back to reference Kerr DR, Kohan L (2008) Local infiltration analgesia: a technique for the control of acute postoperative pain following knee and hip surgery: a case study of 325 patients. Acta Orthop 79:174–183PubMedCrossRef Kerr DR, Kohan L (2008) Local infiltration analgesia: a technique for the control of acute postoperative pain following knee and hip surgery: a case study of 325 patients. Acta Orthop 79:174–183PubMedCrossRef
9.
go back to reference Busch CA, Whitehouse MR, Shore BJ, MacDonald SJ, McCalden RW, Bourne RB (2010) The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty. Clin Orthop Relat Res 468:2152–2159PubMedCrossRef Busch CA, Whitehouse MR, Shore BJ, MacDonald SJ, McCalden RW, Bourne RB (2010) The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty. Clin Orthop Relat Res 468:2152–2159PubMedCrossRef
10.
go back to reference Parvataneni HK, Ranawat AS, Ranawat CS (2007) The use of local periarticular injections in the management of postoperative pain after total hip and knee replacement: a multimodal approach. Instr Course Lect 56:125–131PubMed Parvataneni HK, Ranawat AS, Ranawat CS (2007) The use of local periarticular injections in the management of postoperative pain after total hip and knee replacement: a multimodal approach. Instr Course Lect 56:125–131PubMed
11.
go back to reference Kardash KJ, Sarrazin F, Tessler MJ, Velly AM (2008) Single-dose dexamethasone reduces dynamic pain after total hip arthroplasty. Anesth Analg 106:1253–1257PubMedCrossRef Kardash KJ, Sarrazin F, Tessler MJ, Velly AM (2008) Single-dose dexamethasone reduces dynamic pain after total hip arthroplasty. Anesth Analg 106:1253–1257PubMedCrossRef
12.
go back to reference Pratap JN, Shankar RK, Goroszeniuk T (2007) Co-injection of clonidine prolongs the anesthetic effect of lidocaine skin infiltration by a peripheral action. Anesth Analg 104:982–983PubMedCrossRef Pratap JN, Shankar RK, Goroszeniuk T (2007) Co-injection of clonidine prolongs the anesthetic effect of lidocaine skin infiltration by a peripheral action. Anesth Analg 104:982–983PubMedCrossRef
13.
go back to reference Kampe S, Randebrock G, Kiencke P, Hünseler U, Cranfield K, König DP, Diefenbach C (2001) Comparison of continuous epidural infusion of ropivacaine and sufentanil with intravenous patient-controlled analgesia after total hip replacement. Anaesthesia 56:1189–1193PubMedCrossRef Kampe S, Randebrock G, Kiencke P, Hünseler U, Cranfield K, König DP, Diefenbach C (2001) Comparison of continuous epidural infusion of ropivacaine and sufentanil with intravenous patient-controlled analgesia after total hip replacement. Anaesthesia 56:1189–1193PubMedCrossRef
14.
go back to reference Andersen LJ, Poulsen T, Krogh B, Nielsen T (2007) Postoperative analgesia in total hip arthroplasty: a randomized double-blinded, placebo-controlled study on peroperative and postoperative ropivacaine, ketorolac, and adrenaline wound infiltration. Acta Orthop 78:187–192PubMedCrossRef Andersen LJ, Poulsen T, Krogh B, Nielsen T (2007) Postoperative analgesia in total hip arthroplasty: a randomized double-blinded, placebo-controlled study on peroperative and postoperative ropivacaine, ketorolac, and adrenaline wound infiltration. Acta Orthop 78:187–192PubMedCrossRef
15.
go back to reference Gupta A, Bodin L, Holmstrom B, Berggren L (2001) A systematic review of the peripheral analgesic effects of intraarticular morphine. Anesth Analg 93:761–770PubMedCrossRef Gupta A, Bodin L, Holmstrom B, Berggren L (2001) A systematic review of the peripheral analgesic effects of intraarticular morphine. Anesth Analg 93:761–770PubMedCrossRef
16.
go back to reference Parvataneni HK, Shah VP, Howard H, Cole N, Ranawat AS, Ranawat CS (2007) Controlling pain after total hip and knee arthroplasty using a multimodal protocol with local periarticular injections: a prospective randomized study. J Arthoplasty 22(Suppl 2):33–38CrossRef Parvataneni HK, Shah VP, Howard H, Cole N, Ranawat AS, Ranawat CS (2007) Controlling pain after total hip and knee arthroplasty using a multimodal protocol with local periarticular injections: a prospective randomized study. J Arthoplasty 22(Suppl 2):33–38CrossRef
17.
go back to reference Lunn TH, Kristensen BB, Andersen LØ, Husted H, Otte KS, Gaarn-Larsen L, Kehlet H (2011) Effect of high-dose preoperative methylprednisolone on pain and recovery after total knee arthroplasty: a randomized, placebo-controlled trial. Br J Anaesth 106:230–238PubMedCrossRef Lunn TH, Kristensen BB, Andersen LØ, Husted H, Otte KS, Gaarn-Larsen L, Kehlet H (2011) Effect of high-dose preoperative methylprednisolone on pain and recovery after total knee arthroplasty: a randomized, placebo-controlled trial. Br J Anaesth 106:230–238PubMedCrossRef
18.
go back to reference Essving P, Axelsson K, Kjellberg J, Wallgren O, Gupta A, Lundin A (2010) Reduced morphine consumption and pain intensity with local infiltration analgesia (LIA) following total knee arthroplasty. Acta Orthop 81:354–360PubMedCrossRef Essving P, Axelsson K, Kjellberg J, Wallgren O, Gupta A, Lundin A (2010) Reduced morphine consumption and pain intensity with local infiltration analgesia (LIA) following total knee arthroplasty. Acta Orthop 81:354–360PubMedCrossRef
19.
go back to reference Meunier A, Aspenberg P (2006) Parecoxib impairs early metaphyseal bone healing in rats. Arch Orthop Trauma Surg 126:433–436PubMedCrossRef Meunier A, Aspenberg P (2006) Parecoxib impairs early metaphyseal bone healing in rats. Arch Orthop Trauma Surg 126:433–436PubMedCrossRef
20.
go back to reference McCartney CJ, Duggan E, Apatu E (2007) Should we add clonidine to local anesthetic for peripheral nerve blockade? A qualitative systematic review of the literature. Reg Anesth Pain Med 32:330–338PubMed McCartney CJ, Duggan E, Apatu E (2007) Should we add clonidine to local anesthetic for peripheral nerve blockade? A qualitative systematic review of the literature. Reg Anesth Pain Med 32:330–338PubMed
21.
go back to reference Casati A, Magistris L, Fanelli G, Beccaria P, Cappelleri G, Aldegheri G, Torri G (2000) Small-dose clonidine prolongs postoperative analgesia after sciatic-femoral nerve block with 0.75% ropivacaine for foot surgery. Anesth Analg 91:388–392PubMed Casati A, Magistris L, Fanelli G, Beccaria P, Cappelleri G, Aldegheri G, Torri G (2000) Small-dose clonidine prolongs postoperative analgesia after sciatic-femoral nerve block with 0.75% ropivacaine for foot surgery. Anesth Analg 91:388–392PubMed
22.
go back to reference Brill S, Plaza M (2004) Non-narcotic adjuvants may improve the duration and quality of analgesia after knee arthroscopy: a brief review. Can J Anaesth 51:975–978PubMedCrossRef Brill S, Plaza M (2004) Non-narcotic adjuvants may improve the duration and quality of analgesia after knee arthroscopy: a brief review. Can J Anaesth 51:975–978PubMedCrossRef
23.
go back to reference Eisenach JC, De Kock M, Klimscha W (1996) alpha(2)-adrenergic agonists for regional anesthesia. A clinical review of clonidine (1984–1995). Anesthesiology 85:655–674PubMedCrossRef Eisenach JC, De Kock M, Klimscha W (1996) alpha(2)-adrenergic agonists for regional anesthesia. A clinical review of clonidine (1984–1995). Anesthesiology 85:655–674PubMedCrossRef
24.
go back to reference Andersen KV, Pfeiffer-Jensen M, Haraldsted V, Søballe K (2007) Reduced hospital stay and narcotic consumption, and improved mobilization with local and intraarticular infiltration after hip arthroplasty: a randomized clinical trial of an intraarticular technique versus epidural infusion in 80 patients. Acta Orthop 78:180–186PubMedCrossRef Andersen KV, Pfeiffer-Jensen M, Haraldsted V, Søballe K (2007) Reduced hospital stay and narcotic consumption, and improved mobilization with local and intraarticular infiltration after hip arthroplasty: a randomized clinical trial of an intraarticular technique versus epidural infusion in 80 patients. Acta Orthop 78:180–186PubMedCrossRef
25.
go back to reference Padala PR, Rouholamin E, Mehta RL (2004) The role of drains and tourniquets in primary total knee replacement: a comparative study of TKR performed with drains and tourniquet versus no drains and adrenaline and saline infiltration. J Knee Surg 17:24–27PubMed Padala PR, Rouholamin E, Mehta RL (2004) The role of drains and tourniquets in primary total knee replacement: a comparative study of TKR performed with drains and tourniquet versus no drains and adrenaline and saline infiltration. J Knee Surg 17:24–27PubMed
Metadata
Title
Periarticular infiltration for pain relief after total hip arthroplasty: a comparison with epidural and PCA analgesia
Authors
Ageliki Pandazi
Ilias Kanellopoulos
Konstantinos Kalimeris
Chrysanthi Batistaki
Nikolaos Nikolakopoulos
Paraskevi Matsota
George C. Babis
Georgia Kostopanagiotou
Publication date
01-11-2013
Publisher
Springer Berlin Heidelberg
Published in
Archives of Orthopaedic and Trauma Surgery / Issue 11/2013
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI
https://doi.org/10.1007/s00402-013-1849-8

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