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01-10-2009 | Functional Neuroradiology

Perfusion differences on SPECT and PWI in patients with acute ischemic stroke

Authors: Juho Nuutinen, Yawu Liu, Mikko P. Laakso, Jari O. Karonen, Esko J. Vanninen, Jyrki T. Kuikka, Hannu J. Aronen, Ritva L. Vanninen

Published in: Neuroradiology | Issue 10/2009

Abstract

Introduction

The purposes of the present study were to compare the flow defect volumes on perfusion-weighted magnetic resonance imaging (PWI) and ^99mTc-labeled ethylcysteinate dimer (^99mTc-ECD) single photon emission computed tomography (SPECT) at acute and subacute stages of ischemic stroke and to analyze the relationship between the detected flow defects on the two methods and neurological status and clinical outcomes.

Methods

Perfusion defects on PWI and SPECT were measured within 48 h and on day 8 of the onset of stroke from 22 patients with their first-ever acute supratentorial ischemic stroke. The primary neurological status was evaluated prior to the imaging. Clinical outcome was assessed at 3 months after the onset of the stroke.

Results

The volumes of cerebral blood flow (CBF) defects did not differ between SPECT and PWI within the 48-h examinations. However, the volume of CBF defect was significantly larger on SPECT than on PWI on day 8 (p = 0.03). Within the 48-h examinations, the CBF defect volumes on SPECT and PWI were comparably related to the neurological status. On day 8, the CBF defect volume on SPECT showed higher correlation to the neurological status and more precisely predicted the clinical outcomes at 3 months than PWI.

Conclusions

^99mTC-ECD-SPECT and PWI both have ability to detect cerebral hypoperfusion in patients with ischemic stroke but with some differences. The value of SPECT is more accurate in terms of the delayed outcome, such as prognosis and rehabilitation planning.

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Title: Perfusion differences on SPECT and PWI in patients with acute ischemic stroke
Authors: Juho Nuutinen
Yawu Liu
Mikko P. Laakso
Jari O. Karonen
Esko J. Vanninen
Jyrki T. Kuikka
Hannu J. Aronen
Ritva L. Vanninen
Publication date: 01-10-2009
Publisher: Springer-Verlag
Published in: Neuroradiology / Issue 10/2009
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-009-0569-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Perfusion differences on SPECT and PWI in patients with acute ischemic stroke

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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