Published in:
01-06-2018 | MIGRAINE PATHOGENESIS
Pediatric sporadic hemiplegic migraine (ATP1A2 gene): a case report and brief literature review
Authors:
Ghil Schwarz, Nicoletta Anzalone, Cristina Baldoli, Matteo Impellizzeri, Fabio Minicucci, Giancarlo Comi, Bruno Colombo
Published in:
Neurological Sciences
|
Special Issue 1/2018
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Excerpt
Hemiplegic migraine (HM) is a rare form of migraine with aura: the primary feature of HM is the presence of motor weakness as a manifestation of aura. The first three types of familial hemiplegic migraine account for most of the patients who have familial hemiplegic migraine: FHM1 is caused by mutations in the CACNA1A gene, FHM2 is caused by mutations in the ATP1A2 gene, and FHM3 is caused by mutations in the SCN1A gene. If one first- or second-degree relative has similar symptoms, the disorder can be classified as familial (FHM), otherwise it is classified as sporadic (SHM, 1.2.3.2 in 2018 ICHD classification). Some cases of SHM are caused by one of the genetic mutations that produce FHM, due to either de novo mutations or inheritance from an asymptomatic parent. …
