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Published in: Current Allergy and Asthma Reports 6/2013

01-12-2013 | Pediatric Allergy and Immunology (JM Portnoy and CE Ciaccio, Section Editors)

Pediatric Exercise-Induced Bronchoconstriction: Contemporary Developments in Epidemiology, Pathogenesis, Presentation, Diagnosis, and Therapy

Author: Christopher Randolph

Published in: Current Allergy and Asthma Reports | Issue 6/2013

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Abstract

Exercise-induced bronchoconstriction is transient narrowing of the airways following strenuous exercise. It is the earliest sign of asthma and the last to resolve. EIB is found in 90 % of asthmatics and reflects underlying control of asthma. This review is focused on the contemporary developments in pediatric EIB: the epidemiology, pathogenesis, presentation, diagnosis and management. Proper diagnosis by objective pulmonary function and/or exercise challenge and therapy should allow the pediatric asthmatic to enjoy a healthy lifestyle including participation in the chosen sport.
Literature
1.
go back to reference Aretaeus the Cappadocian. The extant works of Aretaeus the Cappadocian. In: Samter M, editor. Classics in Allergy. Columbus, Ohio: Ross Laboratories, Ohio Aretaeus the Cappadocian. The extant works of Aretaeus the Cappadocian. In: Samter M, editor. Classics in Allergy. Columbus, Ohio: Ross Laboratories, Ohio
3.
go back to reference •• Parsons JP, Hallstrand TS, Mastronarde JG, et al. An official American thoracic society clinical practice guideline: exercise-induced bronchoconstriction. Am J Respir Crit Care Med. 2013;187(9):1016–27. This reference provides the most contemporay state-of-the-art ATS guidelines on EIB.PubMedCrossRef •• Parsons JP, Hallstrand TS, Mastronarde JG, et al. An official American thoracic society clinical practice guideline: exercise-induced bronchoconstriction. Am J Respir Crit Care Med. 2013;187(9):1016–27. This reference provides the most contemporay state-of-the-art ATS guidelines on EIB.PubMedCrossRef
4.
go back to reference •• Anderson SD. The prevention of exercise-induced bronchoconstriction: what are the options? Expert Rev Respir Med. 2012;6(4)):355–7. This article provides the most contemporary and succinct summary of EIB state of the art.PubMedCrossRef •• Anderson SD. The prevention of exercise-induced bronchoconstriction: what are the options? Expert Rev Respir Med. 2012;6(4)):355–7. This article provides the most contemporary and succinct summary of EIB state of the art.PubMedCrossRef
5.
go back to reference •• Anderson SD, Kippelen P. Assessment and prevention of exercise-induced bronchoconstriction. Br J Sports Med. 2012;46(6):391–6. Contemporary state of the art on evaluation and prophylaxis of EIB.PubMedCrossRef •• Anderson SD, Kippelen P. Assessment and prevention of exercise-induced bronchoconstriction. Br J Sports Med. 2012;46(6):391–6. Contemporary state of the art on evaluation and prophylaxis of EIB.PubMedCrossRef
6.
go back to reference •• Anderson SD. Exercise-induced bronchoconstriction in the 21st century. J Am Osteopath Assoc. 2011;111(11 Suppl 7):S3–S10. This article elucidates the contemporary state of the art of the pathogenesis, diagnosis and treatment of EIB.PubMed •• Anderson SD. Exercise-induced bronchoconstriction in the 21st century. J Am Osteopath Assoc. 2011;111(11 Suppl 7):S3–S10. This article elucidates the contemporary state of the art of the pathogenesis, diagnosis and treatment of EIB.PubMed
7.
go back to reference Weiler JM, Anderson SD, Randolph C, et al. Pathogenesis, prevalence, diagnosis, and management of exercise-induced bronchoconstriction: a practice parameter. Ann Allergy Asthma Immunol. 2010;105(6 Suppl):S1–S47. The first US comprehensive practice parameter on the pathogenesis, diagnosis and management of EIB.PubMedCrossRef Weiler JM, Anderson SD, Randolph C, et al. Pathogenesis, prevalence, diagnosis, and management of exercise-induced bronchoconstriction: a practice parameter. Ann Allergy Asthma Immunol. 2010;105(6 Suppl):S1–S47. The first US comprehensive practice parameter on the pathogenesis, diagnosis and management of EIB.PubMedCrossRef
8.
go back to reference Martin RJ. Therapeutic significance of distal airway inflammation in asthma. J Allergy CIin Immunol. 2002;109 Suppl 2:S447–60.CrossRef Martin RJ. Therapeutic significance of distal airway inflammation in asthma. J Allergy CIin Immunol. 2002;109 Suppl 2:S447–60.CrossRef
10.
go back to reference •• Hallstrand TS, Lai Y, Henderson WR, Henderson Jr WR, et al. Epithelial regulation of eicosanoid production in asthma. Pulm Pharmacol Ther. 2012;25(6):432–7. This article provides the most contemporary comprehensive discussion of the epithelial regulation of the pathogenesis of EIB.PubMedCrossRef •• Hallstrand TS, Lai Y, Henderson WR, Henderson Jr WR, et al. Epithelial regulation of eicosanoid production in asthma. Pulm Pharmacol Ther. 2012;25(6):432–7. This article provides the most contemporary comprehensive discussion of the epithelial regulation of the pathogenesis of EIB.PubMedCrossRef
11.
go back to reference Frank PI, Morris JA, Hazell ML, et al. Long term prognosis in preschool children with wheeze: longitudinal postal questionnaire study 1993–2004. BMJ. 2008;336(7658):1423–6.PubMedCrossRef Frank PI, Morris JA, Hazell ML, et al. Long term prognosis in preschool children with wheeze: longitudinal postal questionnaire study 1993–2004. BMJ. 2008;336(7658):1423–6.PubMedCrossRef
12.
go back to reference Stern DA, Morgan WJ, Halonen M, et al. Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study. Lancet. 2008;372(9643):1058–64.PubMedCrossRef Stern DA, Morgan WJ, Halonen M, et al. Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study. Lancet. 2008;372(9643):1058–64.PubMedCrossRef
13.
go back to reference Niles DJ, Kruger SJ, Dardzinski BJ, et al. Exercise-induced bronchoconstriction: reproducibility of hyperpolarized 3He MR imaging. Radiology. 2013;266(2):618–25.PubMedCrossRef Niles DJ, Kruger SJ, Dardzinski BJ, et al. Exercise-induced bronchoconstriction: reproducibility of hyperpolarized 3He MR imaging. Radiology. 2013;266(2):618–25.PubMedCrossRef
14.
go back to reference Becker JM, Rogers J, Rossini G, et al. Asthma deaths during sports: report of a 7-year experience. J Allergy Clin Immunol. 2004;113(2):264–7.PubMedCrossRef Becker JM, Rogers J, Rossini G, et al. Asthma deaths during sports: report of a 7-year experience. J Allergy Clin Immunol. 2004;113(2):264–7.PubMedCrossRef
15.
go back to reference Hamon I, Varechova S, Vieux R, et al. Exercise-induced bronchoconstriction in school-age children born extremely preterm. Pediatr Res. 2013;73(4 Pt 1):464–8.PubMedCrossRef Hamon I, Varechova S, Vieux R, et al. Exercise-induced bronchoconstriction in school-age children born extremely preterm. Pediatr Res. 2013;73(4 Pt 1):464–8.PubMedCrossRef
16.
go back to reference Joshi S, Powell T, Watkins WJ, et al. Exercise-induced bronchoconstriction in school-aged children who had chronic lung disease in infancy. J Pediatr. 2013;162(4):813–818 e1.PubMedCrossRef Joshi S, Powell T, Watkins WJ, et al. Exercise-induced bronchoconstriction in school-aged children who had chronic lung disease in infancy. J Pediatr. 2013;162(4):813–818 e1.PubMedCrossRef
17.
go back to reference Mannix ET, Roberts MA, Dukes HJ, et al. Airways hyperresponsiveness in high school athletes. J Asthma. 2004;41(5):567–74.PubMedCrossRef Mannix ET, Roberts MA, Dukes HJ, et al. Airways hyperresponsiveness in high school athletes. J Asthma. 2004;41(5):567–74.PubMedCrossRef
18.
go back to reference Rupp NT, Guill MF, Brudno DS. Unrecognized exercise-induced bronchospasm in adolescent athletes. Am J Dis Child. 1992;146(8):941–4.PubMed Rupp NT, Guill MF, Brudno DS. Unrecognized exercise-induced bronchospasm in adolescent athletes. Am J Dis Child. 1992;146(8):941–4.PubMed
19.
go back to reference Sudhir P, Prasad CE. Prevalence of exercise-induced bronchospasm in schoolchildren: an urban–rural comparison. J Trop Pediatr. 2003;49(2):104–8.PubMedCrossRef Sudhir P, Prasad CE. Prevalence of exercise-induced bronchospasm in schoolchildren: an urban–rural comparison. J Trop Pediatr. 2003;49(2):104–8.PubMedCrossRef
20.
go back to reference Hallstrand TS, Curtis JR, Koepsell TD, et al. Effectiveness of screening examinations to detect unrecognized exercise-induced bronchoconstriction. J Pediatr. 2002;141(3):343–8.PubMedCrossRef Hallstrand TS, Curtis JR, Koepsell TD, et al. Effectiveness of screening examinations to detect unrecognized exercise-induced bronchoconstriction. J Pediatr. 2002;141(3):343–8.PubMedCrossRef
21.
go back to reference Burr ML, Wat D, Evans C, et al. Asthma prevalence in 1973, 1988 and 2003. Thorax. 2006;61(4):296–9.PubMedCrossRef Burr ML, Wat D, Evans C, et al. Asthma prevalence in 1973, 1988 and 2003. Thorax. 2006;61(4):296–9.PubMedCrossRef
22.
go back to reference De Baets F, Bodart E, Dramaix-Wilmet M, et al. Exercise-induced respiratory symptoms are poor predictors of bronchoconstriction. Pediatr Pulmonol. 2005;39(4):301–5.PubMedCrossRef De Baets F, Bodart E, Dramaix-Wilmet M, et al. Exercise-induced respiratory symptoms are poor predictors of bronchoconstriction. Pediatr Pulmonol. 2005;39(4):301–5.PubMedCrossRef
23.
go back to reference Benarab-Boucherit Y, Mehdioui H, Nedjar F, et al. Prevalence rate of exercise-induced bronchoconstriction in Annaba (Algeria) schoolchildren. J Asthma. 2011;48(5):511–6.PubMedCrossRef Benarab-Boucherit Y, Mehdioui H, Nedjar F, et al. Prevalence rate of exercise-induced bronchoconstriction in Annaba (Algeria) schoolchildren. J Asthma. 2011;48(5):511–6.PubMedCrossRef
24.
go back to reference Cabral AL, Conceicao GM, Saldiva PH, et al. Effect of asthma severity on symptom perception in childhood asthma. Braz J Med Biol Res. 2002;35(3):319–27.PubMedCrossRef Cabral AL, Conceicao GM, Saldiva PH, et al. Effect of asthma severity on symptom perception in childhood asthma. Braz J Med Biol Res. 2002;35(3):319–27.PubMedCrossRef
25.
go back to reference Khan DA. Exercise-induced bronchoconstriction: burden and prevalence. Allergy Asthma Proc. 2012;33(1):1–6.PubMedCrossRef Khan DA. Exercise-induced bronchoconstriction: burden and prevalence. Allergy Asthma Proc. 2012;33(1):1–6.PubMedCrossRef
26.
go back to reference Rundell KW. Pulmonary function decay in women ice hockey players: is there a relationship to ice rink air quality? Inhal Toxicol. 2004;16(3):117–23.PubMedCrossRef Rundell KW. Pulmonary function decay in women ice hockey players: is there a relationship to ice rink air quality? Inhal Toxicol. 2004;16(3):117–23.PubMedCrossRef
27.
go back to reference Bernard A, Nickmilder M, Voisin C, et al. Impact of chlorinated swimming pool attendance on the respiratory health of adolescents. Pediatrics. 2009;124(4):1110–8.PubMedCrossRef Bernard A, Nickmilder M, Voisin C, et al. Impact of chlorinated swimming pool attendance on the respiratory health of adolescents. Pediatrics. 2009;124(4):1110–8.PubMedCrossRef
28.
go back to reference Goldberg S, Mimouni F, Joseph L, et al. Seasonal effect on exercise challenge tests for the diagnosis of exercise-induced bronchoconstriction. Allergy Asthma Proc. 2012;33(5):416–20.PubMedCrossRef Goldberg S, Mimouni F, Joseph L, et al. Seasonal effect on exercise challenge tests for the diagnosis of exercise-induced bronchoconstriction. Allergy Asthma Proc. 2012;33(5):416–20.PubMedCrossRef
29.
go back to reference Rundell KW, Slee JB. Exercise and other indirect challenges to demonstrate asthma or exercise-induced bronchoconstriction in athletes. J Allergy Clin Immunol. 2008;122(2):238–46. quiz 247–8.PubMedCrossRef Rundell KW, Slee JB. Exercise and other indirect challenges to demonstrate asthma or exercise-induced bronchoconstriction in athletes. J Allergy Clin Immunol. 2008;122(2):238–46. quiz 247–8.PubMedCrossRef
30.
go back to reference Addo-Yobo EO, Woodcock A, Allotey A, et al. Exercise-induced bronchospasm and atopy in Ghana: two surveys ten years apart. PLoS Med. 2007;4(2):e70.PubMedCrossRef Addo-Yobo EO, Woodcock A, Allotey A, et al. Exercise-induced bronchospasm and atopy in Ghana: two surveys ten years apart. PLoS Med. 2007;4(2):e70.PubMedCrossRef
31.
go back to reference Kojima N, Ohya Y, Futamura M, et al. Exercise-induced asthma is associated with impaired quality of life among children with asthma in Japan. Allergol Int. 2009;58(2):187–92.PubMedCrossRef Kojima N, Ohya Y, Futamura M, et al. Exercise-induced asthma is associated with impaired quality of life among children with asthma in Japan. Allergol Int. 2009;58(2):187–92.PubMedCrossRef
32.
go back to reference Ostrom NK, Eid NS, Craig TJ, et al. Exercise-induced bronchospasm in children with asthma in the United States: results from the exercise-induced bronchospasm landmark survey. Allergy Asthma Proc. 2011;32(6):425–30.PubMedCrossRef Ostrom NK, Eid NS, Craig TJ, et al. Exercise-induced bronchospasm in children with asthma in the United States: results from the exercise-induced bronchospasm landmark survey. Allergy Asthma Proc. 2011;32(6):425–30.PubMedCrossRef
33.
go back to reference •• Hallstrand TS. New insights into pathogenesis of exercise-induced bronchoconstriction. Curr Opin Allergy Clin Immunol. 2012;12((1):42–8. This is the comprehensive summary of the current pathogenesis of EIB.CrossRef •• Hallstrand TS. New insights into pathogenesis of exercise-induced bronchoconstriction. Curr Opin Allergy Clin Immunol. 2012;12((1):42–8. This is the comprehensive summary of the current pathogenesis of EIB.CrossRef
34.
go back to reference •• Pongdee T, Li JT. Exercise-induced bronchoconstriction. Ann Allergy Asthma Immunol. 2013;110(5):311–5. This article provides the latest insights into the pathogenesis and presentation of EIB.PubMedCrossRef •• Pongdee T, Li JT. Exercise-induced bronchoconstriction. Ann Allergy Asthma Immunol. 2013;110(5):311–5. This article provides the latest insights into the pathogenesis and presentation of EIB.PubMedCrossRef
35.
go back to reference Keskin O, Keskin M, Kucukosmanoglu E, et al. Exhaled RANTES and interleukin 4 levels after exercise challenge in children with asthma. Ann Allergy Asthma Immunol. 2012;109(5):303–8.PubMedCrossRef Keskin O, Keskin M, Kucukosmanoglu E, et al. Exhaled RANTES and interleukin 4 levels after exercise challenge in children with asthma. Ann Allergy Asthma Immunol. 2012;109(5):303–8.PubMedCrossRef
36.
go back to reference He R, Feng J, Xun Q, et al. High-intensity training induces EIB in rats through neuron transdifferentiation of adrenal medulla chromaffin cells. Am J Physiol Lung Cell Mol Physiol. 2013;304(9):L602–12.PubMedCrossRef He R, Feng J, Xun Q, et al. High-intensity training induces EIB in rats through neuron transdifferentiation of adrenal medulla chromaffin cells. Am J Physiol Lung Cell Mol Physiol. 2013;304(9):L602–12.PubMedCrossRef
37.
go back to reference Baek HS, Cho J, Kim JH, et al. Ratio of leukotriene e(4) to exhaled nitric oxide and the therapeutic response in children with exercise-induced bronchoconstriction. Allergy Asthma Immunol Res. 2013;5(1):26–33.PubMedCrossRef Baek HS, Cho J, Kim JH, et al. Ratio of leukotriene e(4) to exhaled nitric oxide and the therapeutic response in children with exercise-induced bronchoconstriction. Allergy Asthma Immunol Res. 2013;5(1):26–33.PubMedCrossRef
38.
go back to reference Chinellato I, Piazza M, Peroni D, et al. Bronchial and alveolar nitric oxide in exercise-induced bronchoconstriction in asthmatic children. Clin Exp Allergy. 2012;42(8):1190–6.PubMedCrossRef Chinellato I, Piazza M, Peroni D, et al. Bronchial and alveolar nitric oxide in exercise-induced bronchoconstriction in asthmatic children. Clin Exp Allergy. 2012;42(8):1190–6.PubMedCrossRef
39.
go back to reference Sastre B, Fernandez-Nieto M, Rodriguez-Nieto MJ, et al. Distinctive bronchial inflammation status in athletes: basophils, a new player. Eur J Appl Physiol. 2013;113(3):703–11.PubMedCrossRef Sastre B, Fernandez-Nieto M, Rodriguez-Nieto MJ, et al. Distinctive bronchial inflammation status in athletes: basophils, a new player. Eur J Appl Physiol. 2013;113(3):703–11.PubMedCrossRef
40.
go back to reference Gulliksson M, Palmberg L, Nilsson G, et al. Release of prostaglandin D2 and leukotriene C4 in response to hyperosmolar stimulation of mast cells. Allergy. 2006;61(12):1473–9.PubMedCrossRef Gulliksson M, Palmberg L, Nilsson G, et al. Release of prostaglandin D2 and leukotriene C4 in response to hyperosmolar stimulation of mast cells. Allergy. 2006;61(12):1473–9.PubMedCrossRef
41.
go back to reference Dougherty RH, RamanK SS, et al. Accumulation of intraepithelial mast cells with a unique protease phenotype in T(h)2 –high asthma. J Allergy Clin Immunol. 2010;125(5):1046.e8–53.e8.CrossRef Dougherty RH, RamanK SS, et al. Accumulation of intraepithelial mast cells with a unique protease phenotype in T(h)2 –high asthma. J Allergy Clin Immunol. 2010;125(5):1046.e8–53.e8.CrossRef
42.
go back to reference Kodesh E, Zaldivar F, Schwindt C, et al. A rat model of exercise-induced asthma: a nonspecific response to a specific immunogen. Am J Physiol Regul Integr Comp Physiol. 2011;300(4):R917–24.PubMedCrossRef Kodesh E, Zaldivar F, Schwindt C, et al. A rat model of exercise-induced asthma: a nonspecific response to a specific immunogen. Am J Physiol Regul Integr Comp Physiol. 2011;300(4):R917–24.PubMedCrossRef
43.
go back to reference Teixeira RN, Teixeira LR, Costa LA, et al. Exercise-induced bronchoconstriction in elite long-distance runners in Brazil. J Bras Pneumol. 2012;38(3):292–8.PubMedCrossRef Teixeira RN, Teixeira LR, Costa LA, et al. Exercise-induced bronchoconstriction in elite long-distance runners in Brazil. J Bras Pneumol. 2012;38(3):292–8.PubMedCrossRef
44.
go back to reference Dickinson J, McConnell A, Whyte G. Diagnosis of exercise-induced bronchoconstriction: eucapnic voluntary hyperpnoea challenges identify previously undiagnosed elite athletes with exercise-induced bronchoconstriction. Br J Sports Med. 2011;45(14):1126–31.PubMedCrossRef Dickinson J, McConnell A, Whyte G. Diagnosis of exercise-induced bronchoconstriction: eucapnic voluntary hyperpnoea challenges identify previously undiagnosed elite athletes with exercise-induced bronchoconstriction. Br J Sports Med. 2011;45(14):1126–31.PubMedCrossRef
45.
go back to reference Beretta S, Vivaldo T, Morelli M, et al. Swimming pool-induced asthma. J Investig Allergol Clin Immunol. 2011;21(3):240–1.PubMed Beretta S, Vivaldo T, Morelli M, et al. Swimming pool-induced asthma. J Investig Allergol Clin Immunol. 2011;21(3):240–1.PubMed
46.
47.
go back to reference Kuchar E, Miskiewicz K, Nitsch-Osuch A, et al. Immunopathology of exercise-induced bronchoconstriction in athletes—A new modified inflammatory hypothesis. Respir Physiol Neurobiol. 2013;187(1):82–7.PubMedCrossRef Kuchar E, Miskiewicz K, Nitsch-Osuch A, et al. Immunopathology of exercise-induced bronchoconstriction in athletes—A new modified inflammatory hypothesis. Respir Physiol Neurobiol. 2013;187(1):82–7.PubMedCrossRef
48.
go back to reference Baek HS, Kim YD, Shin JH, et al. Serum leptin and adiponectin levels correlate with exercise-induced bronchoconstriction in children with asthma. Ann Allergy Asthma Immunol. 2011;107(1):14–21.PubMedCrossRef Baek HS, Kim YD, Shin JH, et al. Serum leptin and adiponectin levels correlate with exercise-induced bronchoconstriction in children with asthma. Ann Allergy Asthma Immunol. 2011;107(1):14–21.PubMedCrossRef
49.
go back to reference Craig TJ, Dispenza MC. Benefits of exercise in asthma. Ann Allergy Asthma Immunol. 2013;110(3):133–140 e2.PubMedCrossRef Craig TJ, Dispenza MC. Benefits of exercise in asthma. Ann Allergy Asthma Immunol. 2013;110(3):133–140 e2.PubMedCrossRef
50.
go back to reference Ansley L, Rae G, Hull JH. Practical approach to exercise-induced bronchoconstriction in athletes. Prim Care Respir J. 2013;22(1):122–5.PubMedCrossRef Ansley L, Rae G, Hull JH. Practical approach to exercise-induced bronchoconstriction in athletes. Prim Care Respir J. 2013;22(1):122–5.PubMedCrossRef
51.
52.
go back to reference Ansley L, Kippelen P, Dickinson J, et al. Misdiagnosis of exercise-induced bronchoconstriction in professional soccer players. Allergy. 2012;67(3):390–5.PubMedCrossRef Ansley L, Kippelen P, Dickinson J, et al. Misdiagnosis of exercise-induced bronchoconstriction in professional soccer players. Allergy. 2012;67(3):390–5.PubMedCrossRef
53.
go back to reference Weinberger M, Abu-Hasan M. Perceptions and pathophysiology of dyspnea and exercise intolerance. Pediatr Clin North Am. 2009;56(1):33–48. ix.PubMedCrossRef Weinberger M, Abu-Hasan M. Perceptions and pathophysiology of dyspnea and exercise intolerance. Pediatr Clin North Am. 2009;56(1):33–48. ix.PubMedCrossRef
54.
go back to reference Tilles SA. Exercise-induced respiratory symptoms: an epidemic among adolescents. Ann Allergy Asthma Immunol. 2010;104(5):361–7. quiz 368–70, 412.PubMedCrossRef Tilles SA. Exercise-induced respiratory symptoms: an epidemic among adolescents. Ann Allergy Asthma Immunol. 2010;104(5):361–7. quiz 368–70, 412.PubMedCrossRef
55.
go back to reference Rundell KW, Weiss P. Exercise-induced bronchoconstriction and vocal cord dysfunction: two sides of the same coin? Curr Sports Med Rep. 2013;12(1):41–6.PubMedCrossRef Rundell KW, Weiss P. Exercise-induced bronchoconstriction and vocal cord dysfunction: two sides of the same coin? Curr Sports Med Rep. 2013;12(1):41–6.PubMedCrossRef
56.
go back to reference Hanks CD, Parsons J, Benninger C, et al. Etiology of dyspnea in elite and recreational athletes. Phys Sportsmed. 2012;40(2):28–33.PubMedCrossRef Hanks CD, Parsons J, Benninger C, et al. Etiology of dyspnea in elite and recreational athletes. Phys Sportsmed. 2012;40(2):28–33.PubMedCrossRef
57.
go back to reference Christensen P, Thomsen SF, Rasmussen N, et al. Exercise-induced laryngeal obstructions objectively assessed using EILOMEA. Eur Arch Otorhinolaryngol. 2010;267(3):401–7.PubMedCrossRef Christensen P, Thomsen SF, Rasmussen N, et al. Exercise-induced laryngeal obstructions objectively assessed using EILOMEA. Eur Arch Otorhinolaryngol. 2010;267(3):401–7.PubMedCrossRef
59.
go back to reference Carlsen KH. Sports in extreme conditions: the impact of exercise in cold temperatures on asthma and bronchial hyper-responsiveness in athletes. Br J Sports Med. 2012;46(11):796–9.PubMedCrossRef Carlsen KH. Sports in extreme conditions: the impact of exercise in cold temperatures on asthma and bronchial hyper-responsiveness in athletes. Br J Sports Med. 2012;46(11):796–9.PubMedCrossRef
60.
go back to reference Rapino D, Consilvio NP, Scaparrotta A, et al. Relationship between exercise-induced bronchospasm (EIB) and asthma control test (ACT) in asthmatic children. J Asthma. 2011;48(10):1081–4.PubMedCrossRef Rapino D, Consilvio NP, Scaparrotta A, et al. Relationship between exercise-induced bronchospasm (EIB) and asthma control test (ACT) in asthmatic children. J Asthma. 2011;48(10):1081–4.PubMedCrossRef
61.
62.
go back to reference van Leeuwen JC, Driessen JM, de Jongh FH, et al. Measuring breakthrough exercise-induced bronchoconstriction in young asthmatic children using a jumping castle. J Allergy Clin Immunol. 2013;131(5):1427–1429 e5.PubMedCrossRef van Leeuwen JC, Driessen JM, de Jongh FH, et al. Measuring breakthrough exercise-induced bronchoconstriction in young asthmatic children using a jumping castle. J Allergy Clin Immunol. 2013;131(5):1427–1429 e5.PubMedCrossRef
63.
go back to reference Kersten ET, Driessen JM, van der Berg JD, et al. Mannitol and exercise challenge tests in asthmatic children. Pediatr Pulmonol. 2009;44(7):655–61.PubMedCrossRef Kersten ET, Driessen JM, van der Berg JD, et al. Mannitol and exercise challenge tests in asthmatic children. Pediatr Pulmonol. 2009;44(7):655–61.PubMedCrossRef
64.
go back to reference Barben J, Kuehni CE, Strippoli MP, et al. Mannitol dry powder challenge in comparison with exercise testing in children. Pediatr Pulmonol. 2011;46(9):842–8.PubMedCrossRef Barben J, Kuehni CE, Strippoli MP, et al. Mannitol dry powder challenge in comparison with exercise testing in children. Pediatr Pulmonol. 2011;46(9):842–8.PubMedCrossRef
65.
go back to reference Driessen JM, van der Palen J, van Aalderen WM, et al. Inspiratory airflow limitation after exercise challenge in cold air in asthmatic children. Respir Med. 2012;106(10):1362–8.PubMedCrossRef Driessen JM, van der Palen J, van Aalderen WM, et al. Inspiratory airflow limitation after exercise challenge in cold air in asthmatic children. Respir Med. 2012;106(10):1362–8.PubMedCrossRef
66.
go back to reference Lipworth BJ, Short PM, Williamson PA, et al. A randomized primary care trial of steroid titration against mannitol in persistent asthma: STAMINA trial. Chest. 2012;141(3):607–15.PubMedCrossRef Lipworth BJ, Short PM, Williamson PA, et al. A randomized primary care trial of steroid titration against mannitol in persistent asthma: STAMINA trial. Chest. 2012;141(3):607–15.PubMedCrossRef
67.
go back to reference Anderson SD, Pearlman DS, Rundell KW, et al. Reproducibility of the airway response to an exercise protocol standardized for intensity, duration, and inspired air conditions, in subjects with symptoms suggestive of asthma. Respir Res. 2010;11:120.PubMedCrossRef Anderson SD, Pearlman DS, Rundell KW, et al. Reproducibility of the airway response to an exercise protocol standardized for intensity, duration, and inspired air conditions, in subjects with symptoms suggestive of asthma. Respir Res. 2010;11:120.PubMedCrossRef
68.
go back to reference Parsons JP, Cosmar D, Phillips G, et al. Screening for exercise-induced bronchoconstriction in college athletes. J Asthma. 2012;49(2):153–7.PubMedCrossRef Parsons JP, Cosmar D, Phillips G, et al. Screening for exercise-induced bronchoconstriction in college athletes. J Asthma. 2012;49(2):153–7.PubMedCrossRef
69.
go back to reference Elkins MR, Brannan JD. Warm-up exercise can reduce exercise-induced bronchoconstriction. Br J Sports Med. 2013;47(10):657–8. Elkins MR, Brannan JD. Warm-up exercise can reduce exercise-induced bronchoconstriction. Br J Sports Med. 2013;47(10):657–8.
70.
go back to reference Mickleborough TD. Salt intake, asthma, and exercise-induced bronchoconstriction: a review. Phys Sportsmed. 2010;38(1):118–31.PubMedCrossRef Mickleborough TD. Salt intake, asthma, and exercise-induced bronchoconstriction: a review. Phys Sportsmed. 2010;38(1):118–31.PubMedCrossRef
71.
go back to reference Pogson Z, McKeever T. Dietary sodium manipulation and asthma. Cochrane Database Syst Rev. 2011;3, CD000436.PubMed Pogson Z, McKeever T. Dietary sodium manipulation and asthma. Cochrane Database Syst Rev. 2011;3, CD000436.PubMed
72.
go back to reference McKenzie DC, McLuckie SL, Stirling DR. The protective effects of continuous and interval exercise in athletes with exercise-induced asthma. Med Sci Sports Exerc. 1994;26(8):951–6.PubMedCrossRef McKenzie DC, McLuckie SL, Stirling DR. The protective effects of continuous and interval exercise in athletes with exercise-induced asthma. Med Sci Sports Exerc. 1994;26(8):951–6.PubMedCrossRef
73.
go back to reference Mickleborough TD, Lindley MR, Turner LA. Comparative effects of a high-intensity interval warm-up and salbutamol on the bronchoconstrictor response to exercise in asthmatic athletes. Int J Sports Med. 2007;28(6):456–62.PubMedCrossRef Mickleborough TD, Lindley MR, Turner LA. Comparative effects of a high-intensity interval warm-up and salbutamol on the bronchoconstrictor response to exercise in asthmatic athletes. Int J Sports Med. 2007;28(6):456–62.PubMedCrossRef
74.
go back to reference Strickland MK, Rowe BH, Spooner CH, et al. Accuracy of eucapnic hyperpnea or mannitol to diagnose exercise –induced bronchoconstriction: a systematic review. Ann Allergy Asthma Immunol. 2011;107(3):229–34.CrossRef Strickland MK, Rowe BH, Spooner CH, et al. Accuracy of eucapnic hyperpnea or mannitol to diagnose exercise –induced bronchoconstriction: a systematic review. Ann Allergy Asthma Immunol. 2011;107(3):229–34.CrossRef
75.
go back to reference Bolger C, Tufvesson E, Anderson SD, et al. Effect of inspired air conditions on exercise-induced bronchoconstriction and urinary CC16 levels in athletes. J Appl Physiol. 2011;111(4):1059–65.PubMedCrossRef Bolger C, Tufvesson E, Anderson SD, et al. Effect of inspired air conditions on exercise-induced bronchoconstriction and urinary CC16 levels in athletes. J Appl Physiol. 2011;111(4):1059–65.PubMedCrossRef
77.
go back to reference Murray JJ, Waitkus-Edwards KR, Yancey SW. Evaluation of fluticasone propionate and fluticasone propionate/salmeterol combination on exercise in pediatric and adolescent patients with asthma. Open Respir Med J. 2011;5:11–8.PubMedCrossRef Murray JJ, Waitkus-Edwards KR, Yancey SW. Evaluation of fluticasone propionate and fluticasone propionate/salmeterol combination on exercise in pediatric and adolescent patients with asthma. Open Respir Med J. 2011;5:11–8.PubMedCrossRef
78.
go back to reference Weiler JM, Nathan RA, Rupp NT, et al. Effect of fluticasone/salmeterol administered via a single device on exercise-induced bronchospasm in patients with persistent asthma. Ann Allergy Asthma Immunol. 2005;94(1):65–72.PubMedCrossRef Weiler JM, Nathan RA, Rupp NT, et al. Effect of fluticasone/salmeterol administered via a single device on exercise-induced bronchospasm in patients with persistent asthma. Ann Allergy Asthma Immunol. 2005;94(1):65–72.PubMedCrossRef
79.
go back to reference Grzelewski T, Stelmach I. Exercise-induced bronchoconstriction in asthmatic children: a comparative systematic review of the available treatment options. Drugs. 2009;69(12):1533–53.PubMedCrossRef Grzelewski T, Stelmach I. Exercise-induced bronchoconstriction in asthmatic children: a comparative systematic review of the available treatment options. Drugs. 2009;69(12):1533–53.PubMedCrossRef
80.
go back to reference Duong M, Amin R, Baatjes AJ, et al. The effect of montelukast, budesonide alone, and in combination on exercise-induced bronchoconstriction. J Allergy Clin Immunol. 2012;130(2):535–9 e3.PubMedCrossRef Duong M, Amin R, Baatjes AJ, et al. The effect of montelukast, budesonide alone, and in combination on exercise-induced bronchoconstriction. J Allergy Clin Immunol. 2012;130(2):535–9 e3.PubMedCrossRef
81.
go back to reference Pedersen L, Elers J, Backer V. Asthma in elite athletes: pathogenesis, diagnosis, differential diagnoses, and treatment. Phys Sportsmed. 2011;39(3):163–71.PubMedCrossRef Pedersen L, Elers J, Backer V. Asthma in elite athletes: pathogenesis, diagnosis, differential diagnoses, and treatment. Phys Sportsmed. 2011;39(3):163–71.PubMedCrossRef
82.
go back to reference Anderson SD, Caillaud C, Brannan JD. Beta 2 agonists and exercise-induced asthma. Clin Rev Allergy Immunol. 2006;31(2–3):163–81.PubMedCrossRef Anderson SD, Caillaud C, Brannan JD. Beta 2 agonists and exercise-induced asthma. Clin Rev Allergy Immunol. 2006;31(2–3):163–81.PubMedCrossRef
83.
go back to reference Haney S, Hancox RJ. Recovery from bronchoconstriction and bronchodilator tolerance. Clin Rev Allergy Immunol. 2006;31(2–3):181–96.PubMedCrossRef Haney S, Hancox RJ. Recovery from bronchoconstriction and bronchodilator tolerance. Clin Rev Allergy Immunol. 2006;31(2–3):181–96.PubMedCrossRef
84.
go back to reference Bandi S. Salivary alpha-amylase as a measure of B-adrenergic receptor activity in physical active individuals with and without exercise-induced bronchonstriction. Abstract Poster #492. J Allergy Clinical Immunol 2013;131(2):Supplement pAB 137. Bandi S. Salivary alpha-amylase as a measure of B-adrenergic receptor activity in physical active individuals with and without exercise-induced bronchonstriction. Abstract Poster #492. J Allergy Clinical Immunol 2013;131(2):Supplement pAB 137.
85.
go back to reference Pearlman DS, van Adelsberg J, Philip G, et al. Onset and duration of protection against exercise-induced bronchoconstriction by a single oral dose of montelukast. Ann Allergy Asthma Immunol. 2006;97(1):98–104.PubMedCrossRef Pearlman DS, van Adelsberg J, Philip G, et al. Onset and duration of protection against exercise-induced bronchoconstriction by a single oral dose of montelukast. Ann Allergy Asthma Immunol. 2006;97(1):98–104.PubMedCrossRef
86.
go back to reference Dryden DM, Spooner CH, Stickland MK. et al. Exercise-induced bronchoconstriction and asthma. Evid Rep Technol Assess (Full Rep), 2010(189): p. 1–154, v-vi. Dryden DM, Spooner CH, Stickland MK. et al. Exercise-induced bronchoconstriction and asthma. Evid Rep Technol Assess (Full Rep), 2010(189): p. 1–154, v-vi.
87.
go back to reference Anderson SD, Brannan JD, Perry CP, et al. Sodium cromoglycate alone and in combination with montelukast on the airway response to mannitol in asthmatic subjects. J Asthma. 2010;47(4):429–33.PubMedCrossRef Anderson SD, Brannan JD, Perry CP, et al. Sodium cromoglycate alone and in combination with montelukast on the airway response to mannitol in asthmatic subjects. J Asthma. 2010;47(4):429–33.PubMedCrossRef
88.
go back to reference Kersten ET, Driessen JM, van Leeuwen JC, et al. Pilot study: The effect of reducing treatment on exercise induced bronchoconstriction. Pediatr Pulmonol. 2010;45(9):927–33.PubMedCrossRef Kersten ET, Driessen JM, van Leeuwen JC, et al. Pilot study: The effect of reducing treatment on exercise induced bronchoconstriction. Pediatr Pulmonol. 2010;45(9):927–33.PubMedCrossRef
89.
go back to reference Jonasson G, Carlsen KH, Hultquist C. Low-dose budesonide improves exercise-induced bronchospasm in schoolchildren. Pediatr Allergy Immunol. 2000;11(2):120–5.PubMedCrossRef Jonasson G, Carlsen KH, Hultquist C. Low-dose budesonide improves exercise-induced bronchospasm in schoolchildren. Pediatr Allergy Immunol. 2000;11(2):120–5.PubMedCrossRef
90.
go back to reference Subbarao P, Duong M, Adelroth E, et al. Effect of ciclesonide dose and duration of therapy on exercise-induced bronchoconstriction in patients with asthma. J Allergy Clin Immunol. 2006;117(5):1008–13.PubMedCrossRef Subbarao P, Duong M, Adelroth E, et al. Effect of ciclesonide dose and duration of therapy on exercise-induced bronchoconstriction in patients with asthma. J Allergy Clin Immunol. 2006;117(5):1008–13.PubMedCrossRef
91.
go back to reference Duong M, Subbarao P, Adelroth E, et al. Sputum eosinophils and the response of exercise-induced bronchoconstriction to corticosteroid in asthma. Chest. 2008;133(2):404–11.PubMedCrossRef Duong M, Subbarao P, Adelroth E, et al. Sputum eosinophils and the response of exercise-induced bronchoconstriction to corticosteroid in asthma. Chest. 2008;133(2):404–11.PubMedCrossRef
92.
go back to reference Djukanovic R, Wilson JW, Britten KM, et al. Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am Rev Respir Dis. 1992;145(3):669–74.PubMedCrossRef Djukanovic R, Wilson JW, Britten KM, et al. Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am Rev Respir Dis. 1992;145(3):669–74.PubMedCrossRef
93.
go back to reference Kersten ET, van Leeuwen JC, Brand PL, et al. Effect of an intranasal corticosteroid on exercise induced bronchoconstriction in asthmatic children. Pediatr Pulmonol. 2012;47(1):27–35.PubMedCrossRef Kersten ET, van Leeuwen JC, Brand PL, et al. Effect of an intranasal corticosteroid on exercise induced bronchoconstriction in asthmatic children. Pediatr Pulmonol. 2012;47(1):27–35.PubMedCrossRef
94.
go back to reference Rakkhong K, Kamchaisatian W, Vilaiyuk S, et al. Exercise-induced bronchoconstriction in rhinitis children without asthma. Asian Pac J Allergy Immunol. 2011;29(3):278–83.PubMed Rakkhong K, Kamchaisatian W, Vilaiyuk S, et al. Exercise-induced bronchoconstriction in rhinitis children without asthma. Asian Pac J Allergy Immunol. 2011;29(3):278–83.PubMed
95.
go back to reference Katelaris CH, Carrozzi FM, Burke TV, et al. Patterns of allergic reactivity and disease in Olympic athletes. Clin J Sport Med. 2006;16(5):401–5.PubMedCrossRef Katelaris CH, Carrozzi FM, Burke TV, et al. Patterns of allergic reactivity and disease in Olympic athletes. Clin J Sport Med. 2006;16(5):401–5.PubMedCrossRef
96.
go back to reference Robson-Ansley P, Howatson G, Tallent J, et al. Prevalence of allergy and upper respiratory tract symptoms in runners of the London marathon. Med Sci Sports Exerc. 2012;44(6):999–1004.PubMedCrossRef Robson-Ansley P, Howatson G, Tallent J, et al. Prevalence of allergy and upper respiratory tract symptoms in runners of the London marathon. Med Sci Sports Exerc. 2012;44(6):999–1004.PubMedCrossRef
97.
go back to reference Pearlman D, Qaqundah P, Matz J, et al. Fluticasone propionate/salmeterol and exercise-induced asthma in children with persistent asthma. Pediatr Pulmonol. 2009;44(5):429–35.PubMedCrossRef Pearlman D, Qaqundah P, Matz J, et al. Fluticasone propionate/salmeterol and exercise-induced asthma in children with persistent asthma. Pediatr Pulmonol. 2009;44(5):429–35.PubMedCrossRef
Metadata
Title
Pediatric Exercise-Induced Bronchoconstriction: Contemporary Developments in Epidemiology, Pathogenesis, Presentation, Diagnosis, and Therapy
Author
Christopher Randolph
Publication date
01-12-2013
Publisher
Springer US
Published in
Current Allergy and Asthma Reports / Issue 6/2013
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-013-0380-x

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