Skip to main content
Top
Published in: Current Allergy and Asthma Reports 5/2016

01-05-2016 | Food Allergy (T Green, Section Editor)

Pearls and Pitfalls in Diagnosing IgE-Mediated Food Allergy

Authors: David R. Stukus, Irene Mikhail

Published in: Current Allergy and Asthma Reports | Issue 5/2016

Login to get access

Abstract

The term “food allergy” is used by many patients and clinicians to describe a range of symptoms that occur after ingestion of specific foods. However, not all symptoms occurring after food exposure are due to an allergic, or immunologic, response. It is important to properly evaluate and diagnose immunoglobulin E (IgE)-mediated food allergy as this results in reproducible, immediate onset, allergic reactions that can progress toward life-threatening anaphylaxis. Proper diagnosis requires understanding of the common foods that cause these reactions in addition to key historical elements such as symptoms, timing and duration of reaction, and risk factors that may predispose to development of IgE-mediated food allergy. Diagnostic testing for food-specific IgE can greatly aid the diagnosis. However, false-positive test results are very common and can lead to overinterpretation, misdiagnosis, and unnecessary dietary elimination. This review discusses important aspects to consider during evaluation of a patient for suspected IgE-mediated food allergy.
Literature
1.••
go back to reference Sampson HA, Aceves S, Bock SA, James J, Jones S, Lang D, et al. Food allergy: a practice parameter update-2014. J Allergy Clin Immunol. 2014;134:1016–25 e43. Most recent practice parameter contains extensive evidence-based discussion of all aspects of food allergy diagnosis and management, along with extensive reference list. Includes summary statements to help navigation through the documen.CrossRefPubMed Sampson HA, Aceves S, Bock SA, James J, Jones S, Lang D, et al. Food allergy: a practice parameter update-2014. J Allergy Clin Immunol. 2014;134:1016–25 e43. Most recent practice parameter contains extensive evidence-based discussion of all aspects of food allergy diagnosis and management, along with extensive reference list. Includes summary statements to help navigation through the documen.CrossRefPubMed
2.
go back to reference Boyce JA, Assa’ad A, Burks AW, Jones SM, Sampson HA, Wood RA, et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol. 2010;126:S1–58.CrossRefPubMedPubMedCentral Boyce JA, Assa’ad A, Burks AW, Jones SM, Sampson HA, Wood RA, et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol. 2010;126:S1–58.CrossRefPubMedPubMedCentral
3.
go back to reference Coon ER, Quinonez RA, Moyer VA, Schroeder AR. Overdiagnosis: how our compulsion for diagnosis may be harming children. Pediatrics. 2014;134:1013–23.CrossRefPubMed Coon ER, Quinonez RA, Moyer VA, Schroeder AR. Overdiagnosis: how our compulsion for diagnosis may be harming children. Pediatrics. 2014;134:1013–23.CrossRefPubMed
4.
go back to reference Verrill L, Bruns R, Luccioli S. Prevalence of self reported food allergy in US adults: 2001, 2006, and 2010. Allergy Asthma Proc. 2015;36(6):458–67. Verrill L, Bruns R, Luccioli S. Prevalence of self reported food allergy in US adults: 2001, 2006, and 2010. Allergy Asthma Proc. 2015;36(6):458–67.
5.
go back to reference Rentzos G, Johanson L, Sjolander S, Telemo E, Ekerljung L. Self-reported adverse reactions and IgE sensitization to common foods in adults with asthma. Clin Transl Allergy. 2015;5:25.CrossRefPubMedPubMedCentral Rentzos G, Johanson L, Sjolander S, Telemo E, Ekerljung L. Self-reported adverse reactions and IgE sensitization to common foods in adults with asthma. Clin Transl Allergy. 2015;5:25.CrossRefPubMedPubMedCentral
6.•
go back to reference Gupta RS, Springston EE, Smith B, Pongracic J, Holl JL, Warrier MR. Parent report of physician diagnosis in pediatric food allergy. J Allergy Clin Immunol. 2013;131:150–6. Large survey of U.S. households identifying data regarding food allergy prevalence and methods used in diagnosis.CrossRefPubMed Gupta RS, Springston EE, Smith B, Pongracic J, Holl JL, Warrier MR. Parent report of physician diagnosis in pediatric food allergy. J Allergy Clin Immunol. 2013;131:150–6. Large survey of U.S. households identifying data regarding food allergy prevalence and methods used in diagnosis.CrossRefPubMed
7.
8.
go back to reference Rona RJ, Keil T, Summers C, Gislason D, Zuidmeer L, Sodergren E, et al. The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol. 2007;120:638–46.CrossRefPubMed Rona RJ, Keil T, Summers C, Gislason D, Zuidmeer L, Sodergren E, et al. The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol. 2007;120:638–46.CrossRefPubMed
9.•
go back to reference Turnbull JL, Adams HN, Gorard DA. Review article: the diagnosis and management of food allergy and food intolerances. Aliment Pharmacol Ther. 2015;41:3–25. In depth up-to-date review of various types of food intolerance, including presentation, diagnosis, and management.CrossRefPubMed Turnbull JL, Adams HN, Gorard DA. Review article: the diagnosis and management of food allergy and food intolerances. Aliment Pharmacol Ther. 2015;41:3–25. In depth up-to-date review of various types of food intolerance, including presentation, diagnosis, and management.CrossRefPubMed
10.
go back to reference Chafen JJ, Newberry SJ, Riedl MA, Bravata DM, Maglione M, Suttorp MJ, et al. Diagnosing and managing common food allergies: a systematic review. JAMA. 2010;303:1848–56.CrossRefPubMed Chafen JJ, Newberry SJ, Riedl MA, Bravata DM, Maglione M, Suttorp MJ, et al. Diagnosing and managing common food allergies: a systematic review. JAMA. 2010;303:1848–56.CrossRefPubMed
11.
go back to reference Cox L, Williams B, Sicherer S, Oppenheimer J, Sher L, Hamilton R, et al. Pearls and pitfalls of allergy diagnostic testing: report from the American College of Allergy, Asthma and Immunology/American Academy of Allergy, Asthma and Immunology Specific IgE Test Task Force. Ann Allergy Asthma Immunol. 2008;101:580–92.CrossRefPubMed Cox L, Williams B, Sicherer S, Oppenheimer J, Sher L, Hamilton R, et al. Pearls and pitfalls of allergy diagnostic testing: report from the American College of Allergy, Asthma and Immunology/American Academy of Allergy, Asthma and Immunology Specific IgE Test Task Force. Ann Allergy Asthma Immunol. 2008;101:580–92.CrossRefPubMed
12.••
go back to reference Nowak-Wegrzyn A, Katz Y, Mehr SS, Koletzko S. Non-IgE-mediated gastrointestinal food allergy. J Allergy Clin Immunol. 2015;135:1114–24. Thorough up-to-date review of non-IgE mediated food allergy, including food protein induced enterocolitis syndrome, food protein induced allergic proctocolitis, and food protein induced enteropathy.CrossRefPubMed Nowak-Wegrzyn A, Katz Y, Mehr SS, Koletzko S. Non-IgE-mediated gastrointestinal food allergy. J Allergy Clin Immunol. 2015;135:1114–24. Thorough up-to-date review of non-IgE mediated food allergy, including food protein induced enterocolitis syndrome, food protein induced allergic proctocolitis, and food protein induced enteropathy.CrossRefPubMed
13.•
go back to reference Berin MC. Immunopathophysiology of food protein-induced enterocolitis syndrome. J Allergy Clin Immunol. 2015;135:1108–13. Review of pathophysiology and clinical experience from multinational centers treating FPIES.CrossRefPubMedPubMedCentral Berin MC. Immunopathophysiology of food protein-induced enterocolitis syndrome. J Allergy Clin Immunol. 2015;135:1108–13. Review of pathophysiology and clinical experience from multinational centers treating FPIES.CrossRefPubMedPubMedCentral
14.
go back to reference Liacouras CA, Furuta GT, Hirano I, Atkins D, Attwood SE, Bonis PA, et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol. 2011;128:3–20. e6; quiz 1-2.CrossRefPubMed Liacouras CA, Furuta GT, Hirano I, Atkins D, Attwood SE, Bonis PA, et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol. 2011;128:3–20. e6; quiz 1-2.CrossRefPubMed
15.••
go back to reference Furuta GT, Katzka DA. Eosinophilic Esophagitis. N Engl J Med. 2015;373:1640–8. Up-to-date review of pathophysiology, diagnosis, and management of eosinophilic esophagitis in children and adults.CrossRefPubMed Furuta GT, Katzka DA. Eosinophilic Esophagitis. N Engl J Med. 2015;373:1640–8. Up-to-date review of pathophysiology, diagnosis, and management of eosinophilic esophagitis in children and adults.CrossRefPubMed
16.
go back to reference Ho MH, Wong WH, Chang C. Clinical spectrum of food allergies: a comprehensive review. Clin Rev Allergy Immunol. 2014;46:225–40.CrossRefPubMed Ho MH, Wong WH, Chang C. Clinical spectrum of food allergies: a comprehensive review. Clin Rev Allergy Immunol. 2014;46:225–40.CrossRefPubMed
17.••
go back to reference Bergmann MM, Caubet JC, Boguniewicz M, Eigenmann PA. Evaluation of food allergy in patients with atopic dermatitis. J Allergy Clin Immunol Pract. 2013;1:22–8. Review article detailing which patients with atopic dermatitis may have food allergy contributing to their disease. Authors discuss diagnosis, interpretation of test results, and management.CrossRefPubMed Bergmann MM, Caubet JC, Boguniewicz M, Eigenmann PA. Evaluation of food allergy in patients with atopic dermatitis. J Allergy Clin Immunol Pract. 2013;1:22–8. Review article detailing which patients with atopic dermatitis may have food allergy contributing to their disease. Authors discuss diagnosis, interpretation of test results, and management.CrossRefPubMed
18.••
go back to reference Fasano A, Catassi C. Clinical practice. Celiac disease. N Engl J Med. 2012;367:2419–26. Excellent review of celiac disease, including differential diagnosis and differences between celiac, non-celiac gluten sensitivity, and wheat allergy.CrossRefPubMed Fasano A, Catassi C. Clinical practice. Celiac disease. N Engl J Med. 2012;367:2419–26. Excellent review of celiac disease, including differential diagnosis and differences between celiac, non-celiac gluten sensitivity, and wheat allergy.CrossRefPubMed
19.
go back to reference Biesiekierski JR, Muir JG, Gibson PR. Is gluten a cause of gastrointestinal symptoms in people without celiac disease? Curr Allergy Asthma Rep. 2013;13:631–8.CrossRefPubMed Biesiekierski JR, Muir JG, Gibson PR. Is gluten a cause of gastrointestinal symptoms in people without celiac disease? Curr Allergy Asthma Rep. 2013;13:631–8.CrossRefPubMed
21.
go back to reference Simons FE, Ardusso LR, Bilo MB, Dimov V, Ebisawa M, El-Gamal YM, et al. 2012 Update: World Allergy Organization Guidelines for the assessment and management of anaphylaxis. Curr Opin Allergy Clin Immunol. 2012;12:389–99.CrossRefPubMed Simons FE, Ardusso LR, Bilo MB, Dimov V, Ebisawa M, El-Gamal YM, et al. 2012 Update: World Allergy Organization Guidelines for the assessment and management of anaphylaxis. Curr Opin Allergy Clin Immunol. 2012;12:389–99.CrossRefPubMed
22.
go back to reference Gupta RS, Springston EE, Warrier MR, Smith B, Kumar R, Pongracic J, et al. The prevalence, severity, and distribution of childhood food allergy in the United States. Pediatrics. 2011;128:e9–17.CrossRefPubMed Gupta RS, Springston EE, Warrier MR, Smith B, Kumar R, Pongracic J, et al. The prevalence, severity, and distribution of childhood food allergy in the United States. Pediatrics. 2011;128:e9–17.CrossRefPubMed
24.
go back to reference Osborne NJ, Koplin JJ, Martin PE, Gurrin LC, Lowe AJ, Matheson MC, et al. Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants. J Allergy Clin Immunol. 2011;127:668–76. e1-2.CrossRefPubMed Osborne NJ, Koplin JJ, Martin PE, Gurrin LC, Lowe AJ, Matheson MC, et al. Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants. J Allergy Clin Immunol. 2011;127:668–76. e1-2.CrossRefPubMed
25.
26.
go back to reference Wilson BG, Bahna SL. Adverse reactions to food additives. Ann Allergy Asthma Immunol. 2005;95:499–507. quiz , 70.CrossRefPubMed Wilson BG, Bahna SL. Adverse reactions to food additives. Ann Allergy Asthma Immunol. 2005;95:499–507. quiz , 70.CrossRefPubMed
27.
28.
go back to reference Kim JS, Sicherer SH. Living with food allergy: allergen avoidance. Pediatr Clin North Am. 2011;58:459–70. xi.CrossRefPubMed Kim JS, Sicherer SH. Living with food allergy: allergen avoidance. Pediatr Clin North Am. 2011;58:459–70. xi.CrossRefPubMed
30.
go back to reference Caubet JC, Eigenmann PA. Allergic triggers in atopic dermatitis. Immunol Allergy Clin North Am. 2010;30:289–307.CrossRefPubMed Caubet JC, Eigenmann PA. Allergic triggers in atopic dermatitis. Immunol Allergy Clin North Am. 2010;30:289–307.CrossRefPubMed
31.
go back to reference Clark AT, Ewan PW. The development and progression of allergy to multiple nuts at different ages. Pediatr Allergy Immunol. 2005;16:507–11.CrossRefPubMed Clark AT, Ewan PW. The development and progression of allergy to multiple nuts at different ages. Pediatr Allergy Immunol. 2005;16:507–11.CrossRefPubMed
32.
go back to reference Leung PS, Chow WK, Duffey S, Kwan HS, Gershwin ME, Chu KH. IgE reactivity against a cross-reactive allergen in crustacea and mollusca: evidence for tropomyosin as the common allergen. J Allergy Clin Immunol. 1996;98:954–61.CrossRefPubMed Leung PS, Chow WK, Duffey S, Kwan HS, Gershwin ME, Chu KH. IgE reactivity against a cross-reactive allergen in crustacea and mollusca: evidence for tropomyosin as the common allergen. J Allergy Clin Immunol. 1996;98:954–61.CrossRefPubMed
33.
go back to reference Kazatsky AM, Wood RA. Classification of food allergens and cross-reactivity. Curr Allergy Asthma Rep. 2016;16:22.CrossRefPubMed Kazatsky AM, Wood RA. Classification of food allergens and cross-reactivity. Curr Allergy Asthma Rep. 2016;16:22.CrossRefPubMed
35.•
go back to reference Bauer RN, Manohar M, Singh AM, Jay DC, Nadeau KC. The future of biologics: applications for food allergy. J Allergy Clin Immunol. 2015;135:312–23. Up-to-date review of immunologic pathogenesis underlying food allergy development, along with attempts to modulate through immunotherapy.CrossRefPubMed Bauer RN, Manohar M, Singh AM, Jay DC, Nadeau KC. The future of biologics: applications for food allergy. J Allergy Clin Immunol. 2015;135:312–23. Up-to-date review of immunologic pathogenesis underlying food allergy development, along with attempts to modulate through immunotherapy.CrossRefPubMed
36.
go back to reference Lieberman JA, Chehade M. Use of omalizumab in the treatment of food allergy and anaphylaxis. Curr Allergy Asthma Rep. 2013;13:78–84.CrossRefPubMed Lieberman JA, Chehade M. Use of omalizumab in the treatment of food allergy and anaphylaxis. Curr Allergy Asthma Rep. 2013;13:78–84.CrossRefPubMed
37.
go back to reference Sampson HA. Food allergy. Part 1: immunopathogenesis and clinical disorders. J Allergy Clin Immunol. 1999;103:717–28.CrossRefPubMed Sampson HA. Food allergy. Part 1: immunopathogenesis and clinical disorders. J Allergy Clin Immunol. 1999;103:717–28.CrossRefPubMed
39.
go back to reference Bird JA, Lack G, Perry TT. Clinical management of food allergy. J Allergy Clin Immunol Pract. 2015;3:1–11. quiz 2.CrossRefPubMed Bird JA, Lack G, Perry TT. Clinical management of food allergy. J Allergy Clin Immunol Pract. 2015;3:1–11. quiz 2.CrossRefPubMed
40.
go back to reference Burks W. Skin manifestations of food allergy. Pediatrics. 2003;111:1617–24.PubMed Burks W. Skin manifestations of food allergy. Pediatrics. 2003;111:1617–24.PubMed
41.
go back to reference Sampson HA, Munoz-Furlong A, Campbell RL, Adkinson Jr NF, Bock SA, Branum A, et al. Second symposium on the definition and management of anaphylaxis: summary report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. J Allergy Clin Immunol. 2006;117:391–7.CrossRefPubMed Sampson HA, Munoz-Furlong A, Campbell RL, Adkinson Jr NF, Bock SA, Branum A, et al. Second symposium on the definition and management of anaphylaxis: summary report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. J Allergy Clin Immunol. 2006;117:391–7.CrossRefPubMed
42.
go back to reference Perry TT, Matsui EC, Conover-Walker MK, Wood RA. Risk of oral food challenges. J Allergy Clin Immunol. 2004;114:1164–8.CrossRefPubMed Perry TT, Matsui EC, Conover-Walker MK, Wood RA. Risk of oral food challenges. J Allergy Clin Immunol. 2004;114:1164–8.CrossRefPubMed
43.•
go back to reference Simons FE, Ebisawa M, Sanchez-Borges M, Thong BY, Worm M, Tanno LK, et al. 2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines. World Allergy Organ J. 2015;8:32. In-depth review of presenting features, diagnosis, and treatment of anaphylaxis.CrossRefPubMedPubMedCentral Simons FE, Ebisawa M, Sanchez-Borges M, Thong BY, Worm M, Tanno LK, et al. 2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines. World Allergy Organ J. 2015;8:32. In-depth review of presenting features, diagnosis, and treatment of anaphylaxis.CrossRefPubMedPubMedCentral
45.
go back to reference Webb LM, Lieberman P. Anaphylaxis: a review of 601 cases. Ann Allergy Asthma Immunol. 2006;97:39–43.CrossRefPubMed Webb LM, Lieberman P. Anaphylaxis: a review of 601 cases. Ann Allergy Asthma Immunol. 2006;97:39–43.CrossRefPubMed
46.
go back to reference Sampson HA. Food allergy. Part 2: diagnosis and management. J Allergy Clin Immunol. 1999;103:981–9.CrossRefPubMed Sampson HA. Food allergy. Part 2: diagnosis and management. J Allergy Clin Immunol. 1999;103:981–9.CrossRefPubMed
47.
go back to reference Tole JW, Lieberman P. Biphasic anaphylaxis: review of incidence, clinical predictors, and observation recommendations. Immunol Allergy Clin North Am. 2007;27:309–26. viii.CrossRefPubMed Tole JW, Lieberman P. Biphasic anaphylaxis: review of incidence, clinical predictors, and observation recommendations. Immunol Allergy Clin North Am. 2007;27:309–26. viii.CrossRefPubMed
48.•
go back to reference Bernstein JA, Lang DM, Khan DA, Craig T, Dreyfus D, Hsieh F, et al. The diagnosis and management of acute and chronic urticaria: 2014 update. J Allergy Clin Immunol. 2014;133:1270–7. Provides thorough discussion and extensive evidence-based recommendations regarding the diagnosis, differential diagnosis, prognosis, evaluation, and treatment of urticaria.CrossRefPubMed Bernstein JA, Lang DM, Khan DA, Craig T, Dreyfus D, Hsieh F, et al. The diagnosis and management of acute and chronic urticaria: 2014 update. J Allergy Clin Immunol. 2014;133:1270–7. Provides thorough discussion and extensive evidence-based recommendations regarding the diagnosis, differential diagnosis, prognosis, evaluation, and treatment of urticaria.CrossRefPubMed
49.
go back to reference Perry TT, Conover-Walker MK, Pomes A, Chapman MD, Wood RA. Distribution of peanut allergen in the environment. J Allergy Clin Immunol. 2004;113:973–6.CrossRefPubMed Perry TT, Conover-Walker MK, Pomes A, Chapman MD, Wood RA. Distribution of peanut allergen in the environment. J Allergy Clin Immunol. 2004;113:973–6.CrossRefPubMed
50.
go back to reference Simonte SJ, Ma S, Mofidi S, Sicherer SH. Relevance of casual contact with peanut butter in children with peanut allergy. J Allergy Clin Immunol. 2003;112:180–2.CrossRefPubMed Simonte SJ, Ma S, Mofidi S, Sicherer SH. Relevance of casual contact with peanut butter in children with peanut allergy. J Allergy Clin Immunol. 2003;112:180–2.CrossRefPubMed
51.•
go back to reference Leonardi S, Pecoraro R, Filippelli M, Miraglia Del Giudice M, Marseglia G, Salpietro C, et al. Allergic reactions to foods by inhalation in children. Allergy Asthma Proc. 2014;35:288–94. Article focusing inhalational food allergy reactions in children including risk factors within the child and type and preparation of food associated with such reactions.CrossRefPubMed Leonardi S, Pecoraro R, Filippelli M, Miraglia Del Giudice M, Marseglia G, Salpietro C, et al. Allergic reactions to foods by inhalation in children. Allergy Asthma Proc. 2014;35:288–94. Article focusing inhalational food allergy reactions in children including risk factors within the child and type and preparation of food associated with such reactions.CrossRefPubMed
52.
53.
go back to reference Simons FE, Ardusso LR, Bilo MB, Cardona V, Ebisawa M, El-Gamal YM, et al. International consensus on (ICON) anaphylaxis. World Allergy Organ J. 2014;7:9.CrossRefPubMedPubMedCentral Simons FE, Ardusso LR, Bilo MB, Cardona V, Ebisawa M, El-Gamal YM, et al. International consensus on (ICON) anaphylaxis. World Allergy Organ J. 2014;7:9.CrossRefPubMedPubMedCentral
54.•
go back to reference Ko BS, Kim WY, Ryoo SM, Ahn S, Sohn CH, Seo DW, et al. Biphasic reactions in patients with anaphylaxis treated with corticosteroids. Ann Allergy Asthma Immunol. 2015;115:312–6. A large, retrospective study describing risk factors associated with development of biphasic anaphylaxis.CrossRefPubMed Ko BS, Kim WY, Ryoo SM, Ahn S, Sohn CH, Seo DW, et al. Biphasic reactions in patients with anaphylaxis treated with corticosteroids. Ann Allergy Asthma Immunol. 2015;115:312–6. A large, retrospective study describing risk factors associated with development of biphasic anaphylaxis.CrossRefPubMed
55.
go back to reference Lieberman P. Biphasic anaphylactic reactions. Ann Allergy Asthma Immunol. 2005;95:217–26. quiz 26, 58.CrossRefPubMed Lieberman P. Biphasic anaphylactic reactions. Ann Allergy Asthma Immunol. 2005;95:217–26. quiz 26, 58.CrossRefPubMed
56.
go back to reference Alqurashi W, Stiell I, Chan K, Neto G, Alsadoon A, Wells G. Epidemiology and clinical predictors of biphasic reactions in children with anaphylaxis. Ann Allergy Asthma Immunol. 2015;115:217–23. e2.CrossRefPubMed Alqurashi W, Stiell I, Chan K, Neto G, Alsadoon A, Wells G. Epidemiology and clinical predictors of biphasic reactions in children with anaphylaxis. Ann Allergy Asthma Immunol. 2015;115:217–23. e2.CrossRefPubMed
57.
go back to reference Nguyen TA, Leonard SA, Eichenfield LF. An update on pediatric atopic dermatitis and food allergies. J Pediatr. 2015;167:752–6.CrossRefPubMed Nguyen TA, Leonard SA, Eichenfield LF. An update on pediatric atopic dermatitis and food allergies. J Pediatr. 2015;167:752–6.CrossRefPubMed
58.
go back to reference Lieberman JA, Sicherer SH. Diagnosis of food allergy: epicutaneous skin tests, in vitro tests, and oral food challenge. Curr Allergy Asthma Rep. 2011;11:58–64.CrossRefPubMed Lieberman JA, Sicherer SH. Diagnosis of food allergy: epicutaneous skin tests, in vitro tests, and oral food challenge. Curr Allergy Asthma Rep. 2011;11:58–64.CrossRefPubMed
59.
go back to reference Bernstein IL, Li JT, Bernstein DI, Hamilton R, Spector SL, Tan R, et al. Allergy diagnostic testing: an updated practice parameter. Ann Allergy Asthma Immunol. 2008;100:S1–148.CrossRef Bernstein IL, Li JT, Bernstein DI, Hamilton R, Spector SL, Tan R, et al. Allergy diagnostic testing: an updated practice parameter. Ann Allergy Asthma Immunol. 2008;100:S1–148.CrossRef
60.
go back to reference Edwards KP, Martinez BA. Atopy patch testing for foods: a review of the literature. Allergy Asthma Proc. 2014;35:435–43.CrossRefPubMed Edwards KP, Martinez BA. Atopy patch testing for foods: a review of the literature. Allergy Asthma Proc. 2014;35:435–43.CrossRefPubMed
61.
go back to reference Isolauri E, Turjanmaa K. Combined skin prick and patch testing enhances identification of food allergy in infants with atopic dermatitis. J Allergy Clin Immunol. 1996;97:9–15.CrossRefPubMed Isolauri E, Turjanmaa K. Combined skin prick and patch testing enhances identification of food allergy in infants with atopic dermatitis. J Allergy Clin Immunol. 1996;97:9–15.CrossRefPubMed
62.
go back to reference Mehl A, Rolinck-Werninghaus C, Staden U, Verstege A, Wahn U, Beyer K, et al. The atopy patch test in the diagnostic workup of suspected food-related symptoms in children. J Allergy Clin Immunol. 2006;118:923–9.CrossRefPubMed Mehl A, Rolinck-Werninghaus C, Staden U, Verstege A, Wahn U, Beyer K, et al. The atopy patch test in the diagnostic workup of suspected food-related symptoms in children. J Allergy Clin Immunol. 2006;118:923–9.CrossRefPubMed
63.••
go back to reference Bird JA, Crain M, Varshney P. Food allergen panel testing often results in misdiagnosis of food allergy. J Pediatr. 2015;166:97–100. Must read for anyone who favors food allergen panel testing. This retrospective review characterizes the high rates of misdiagnosis, unnecessary dietary avoidance, and economic burden associated with use of food serum IgE panels.CrossRefPubMed Bird JA, Crain M, Varshney P. Food allergen panel testing often results in misdiagnosis of food allergy. J Pediatr. 2015;166:97–100. Must read for anyone who favors food allergen panel testing. This retrospective review characterizes the high rates of misdiagnosis, unnecessary dietary avoidance, and economic burden associated with use of food serum IgE panels.CrossRefPubMed
64.••
go back to reference Chokshi NY, Sicherer SH. Interpreting IgE sensitization tests in food allergy. Expert Rev Clin Immunol 2015:1–15. doi:10.1586/1744666X.2016.1124761. Detailed up-to-date discussion of interpretation of IgE testing in the evaluatiojn of food allergy. Chokshi NY, Sicherer SH. Interpreting IgE sensitization tests in food allergy. Expert Rev Clin Immunol 2015:1–15. doi:10.​1586/​1744666X.​2016.​1124761. Detailed up-to-date discussion of interpretation of IgE testing in the evaluatiojn of food allergy.
65.
go back to reference Soares-Weiser K, Takwoingi Y, Panesar SS, Muraro A, Werfel T, Hoffmann-Sommergruber K, et al. The diagnosis of food allergy: a systematic review and meta-analysis. Allergy. 2014;69:76–86.CrossRefPubMed Soares-Weiser K, Takwoingi Y, Panesar SS, Muraro A, Werfel T, Hoffmann-Sommergruber K, et al. The diagnosis of food allergy: a systematic review and meta-analysis. Allergy. 2014;69:76–86.CrossRefPubMed
66.•
go back to reference Wood RA, Sicherer SH, Vickery BP, Jones SM, Liu AH, Fleischer DM, et al. The natural history of milk allergy in an observational cohort. J Allergy Clin Immunol. 2013;131:805–12. Observational cohort of infants with milk allergy who were followed long term to identify prognosis, baseline characteristics and immunologic parameters associated with resolution of milk allergy.CrossRefPubMedPubMedCentral Wood RA, Sicherer SH, Vickery BP, Jones SM, Liu AH, Fleischer DM, et al. The natural history of milk allergy in an observational cohort. J Allergy Clin Immunol. 2013;131:805–12. Observational cohort of infants with milk allergy who were followed long term to identify prognosis, baseline characteristics and immunologic parameters associated with resolution of milk allergy.CrossRefPubMedPubMedCentral
67.
go back to reference Sporik R, Hill DJ, Hosking CS. Specificity of allergen skin testing in predicting positive open food challenges to milk, egg and peanut in children. Clin Exp Allergy. 2000;30:1540–6.CrossRefPubMed Sporik R, Hill DJ, Hosking CS. Specificity of allergen skin testing in predicting positive open food challenges to milk, egg and peanut in children. Clin Exp Allergy. 2000;30:1540–6.CrossRefPubMed
68.
go back to reference Sampson HA. Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol. 2001;107:891–6.CrossRefPubMed Sampson HA. Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol. 2001;107:891–6.CrossRefPubMed
69.
go back to reference Garcia-Ara C, Boyano-Martinez T, Diaz-Pena JM, Martin-Munoz F, Reche-Frutos M, Martin-Esteban M. Specific IgE levels in the diagnosis of immediate hypersensitivity to cows’ milk protein in the infant. J Allergy Clin Immunol. 2001;107:185–90.CrossRefPubMed Garcia-Ara C, Boyano-Martinez T, Diaz-Pena JM, Martin-Munoz F, Reche-Frutos M, Martin-Esteban M. Specific IgE levels in the diagnosis of immediate hypersensitivity to cows’ milk protein in the infant. J Allergy Clin Immunol. 2001;107:185–90.CrossRefPubMed
70.
go back to reference Clark AT, Ewan PW. Interpretation of tests for nut allergy in one thousand patients, in relation to allergy or tolerance. Clin Exp Allergy. 2003;33:1041–5.CrossRefPubMed Clark AT, Ewan PW. Interpretation of tests for nut allergy in one thousand patients, in relation to allergy or tolerance. Clin Exp Allergy. 2003;33:1041–5.CrossRefPubMed
71.
go back to reference Celik-Bilgili S, Mehl A, Verstege A, Staden U, Nocon M, Beyer K, et al. The predictive value of specific immunoglobulin E levels in serum for the outcome of oral food challenges. Clin Exp Allergy. 2005;35:268–73.CrossRefPubMed Celik-Bilgili S, Mehl A, Verstege A, Staden U, Nocon M, Beyer K, et al. The predictive value of specific immunoglobulin E levels in serum for the outcome of oral food challenges. Clin Exp Allergy. 2005;35:268–73.CrossRefPubMed
73.
go back to reference Sicherer SH, Sampson HA. Food allergy: epidemiology, pathogenesis, diagnosis, and treatment. J Allergy Clin Immunol. 2014;133:291–307. quiz 8.CrossRefPubMed Sicherer SH, Sampson HA. Food allergy: epidemiology, pathogenesis, diagnosis, and treatment. J Allergy Clin Immunol. 2014;133:291–307. quiz 8.CrossRefPubMed
74.
go back to reference Calvani M, Berti I, Fiocchi A, Galli E, Giorgio V, Martelli A, et al. Oral food challenge: safety, adherence to guidelines and predictive value of skin prick testing. Pediatr Allergy Immunol. 2012;23:755–61.CrossRefPubMed Calvani M, Berti I, Fiocchi A, Galli E, Giorgio V, Martelli A, et al. Oral food challenge: safety, adherence to guidelines and predictive value of skin prick testing. Pediatr Allergy Immunol. 2012;23:755–61.CrossRefPubMed
75.
go back to reference Beyer K, Teuber SS. Food allergy diagnostics: scientific and unproven procedures. Curr Opin Allergy Clin Immunol. 2005;5:261–6.CrossRefPubMed Beyer K, Teuber SS. Food allergy diagnostics: scientific and unproven procedures. Curr Opin Allergy Clin Immunol. 2005;5:261–6.CrossRefPubMed
76.
go back to reference Wood RA. The likelihood of remission of food allergy in children: when is the optimal time for challenge? Curr Allergy Asthma Rep. 2012;12:42–7.CrossRefPubMed Wood RA. The likelihood of remission of food allergy in children: when is the optimal time for challenge? Curr Allergy Asthma Rep. 2012;12:42–7.CrossRefPubMed
77.
go back to reference Nowak-Wegrzyn A, Assa’ad AH, Bahna SL, Bock SA, Sicherer SH, Teuber SS. Work Group report: oral food challenge testing. J Allergy Clin Immunol. 2009;123:S365–83.CrossRefPubMed Nowak-Wegrzyn A, Assa’ad AH, Bahna SL, Bock SA, Sicherer SH, Teuber SS. Work Group report: oral food challenge testing. J Allergy Clin Immunol. 2009;123:S365–83.CrossRefPubMed
78.
go back to reference Caffarelli C, Petroccione T. False-negative food challenges in children with suspected food allergy. Lancet. 2001;358:1871–2.CrossRefPubMed Caffarelli C, Petroccione T. False-negative food challenges in children with suspected food allergy. Lancet. 2001;358:1871–2.CrossRefPubMed
79.
go back to reference Skolnick HS, Conover-Walker MK, Koerner CB, Sampson HA, Burks W, Wood RA. The natural history of peanut allergy. J Allergy Clin Immunol. 2001;107:367–74.CrossRefPubMed Skolnick HS, Conover-Walker MK, Koerner CB, Sampson HA, Burks W, Wood RA. The natural history of peanut allergy. J Allergy Clin Immunol. 2001;107:367–74.CrossRefPubMed
80.
go back to reference Peters RL, Dharmage SC, Gurrin LC, Koplin JJ, Ponsonby AL, Lowe AJ, et al. The natural history and clinical predictors of egg allergy in the first 2 years of life: a prospective, population-based cohort study. J Allergy Clin Immunol. 2014;133:485–91.CrossRefPubMed Peters RL, Dharmage SC, Gurrin LC, Koplin JJ, Ponsonby AL, Lowe AJ, et al. The natural history and clinical predictors of egg allergy in the first 2 years of life: a prospective, population-based cohort study. J Allergy Clin Immunol. 2014;133:485–91.CrossRefPubMed
81.•
go back to reference Schussler E, Kattan J. Allergen component testing in the diagnosis of food allergy. Curr Allergy Asthma Rep. 2015;15:55. Up-to-date in depth review addressing current understanding and utility of performing component testing for evaluation of food allergy.CrossRefPubMed Schussler E, Kattan J. Allergen component testing in the diagnosis of food allergy. Curr Allergy Asthma Rep. 2015;15:55. Up-to-date in depth review addressing current understanding and utility of performing component testing for evaluation of food allergy.CrossRefPubMed
82.
go back to reference Bartnikas LM, Sheehan WJ, Larabee KS, Petty C, Schneider LC, Phipatanakul W. Ovomucoid is not superior to egg white testing in predicting tolerance to baked egg. J Allergy Clin Immunol Pract. 2013;1:354–60.CrossRefPubMedPubMedCentral Bartnikas LM, Sheehan WJ, Larabee KS, Petty C, Schneider LC, Phipatanakul W. Ovomucoid is not superior to egg white testing in predicting tolerance to baked egg. J Allergy Clin Immunol Pract. 2013;1:354–60.CrossRefPubMedPubMedCentral
84.
go back to reference Dang TD, Tang M, Choo S, Licciardi PV, Koplin JJ, Martin PE, et al. Increasing the accuracy of peanut allergy diagnosis by using Ara h 2. J Allergy Clin Immunol. 2012;129:1056–63.CrossRefPubMed Dang TD, Tang M, Choo S, Licciardi PV, Koplin JJ, Martin PE, et al. Increasing the accuracy of peanut allergy diagnosis by using Ara h 2. J Allergy Clin Immunol. 2012;129:1056–63.CrossRefPubMed
85.
go back to reference Berneder M, Bublin M, Hoffmann-Sommergruber K, Hawranek T, Lang R. Allergen chip diagnosis for soy-allergic patients: Gly m 4 as a marker for severe food-allergic reactions to soy. Int Arch Allergy Immunol. 2013;161:229–33.CrossRefPubMedPubMedCentral Berneder M, Bublin M, Hoffmann-Sommergruber K, Hawranek T, Lang R. Allergen chip diagnosis for soy-allergic patients: Gly m 4 as a marker for severe food-allergic reactions to soy. Int Arch Allergy Immunol. 2013;161:229–33.CrossRefPubMedPubMedCentral
86.•
go back to reference Tuano KS, Davis CM. Utility of component-resolved diagnostics in food allergy. Curr Allergy Asthma Rep. 2015;15:32. Review of component testing for food allergy, including limitations of interpretation of results in certain age and geographic populations.CrossRefPubMed Tuano KS, Davis CM. Utility of component-resolved diagnostics in food allergy. Curr Allergy Asthma Rep. 2015;15:32. Review of component testing for food allergy, including limitations of interpretation of results in certain age and geographic populations.CrossRefPubMed
87.
88.
go back to reference Glaumann S, Nopp A, Johansson SG, Rudengren M, Borres MP, Nilsson C. Basophil allergen threshold sensitivity, CD-sens, IgE-sensitization and DBPCFC in peanut-sensitized children. Allergy. 2012;67:242–7.CrossRefPubMed Glaumann S, Nopp A, Johansson SG, Rudengren M, Borres MP, Nilsson C. Basophil allergen threshold sensitivity, CD-sens, IgE-sensitization and DBPCFC in peanut-sensitized children. Allergy. 2012;67:242–7.CrossRefPubMed
89.•
go back to reference Song Y, Wang J, Leung N, Wang LX, Lisann L, Sicherer SH, et al. Correlations between basophil activation, allergen-specific IgE with outcome and severity of oral food challenges. Ann Allergy Asthma Immunol. 2015;114:319–26. One of the largest studies to date evaluating the utility of basophil activation testing versus traditional skin prick or serum IgE testing in the evaluation of food allergy.CrossRefPubMed Song Y, Wang J, Leung N, Wang LX, Lisann L, Sicherer SH, et al. Correlations between basophil activation, allergen-specific IgE with outcome and severity of oral food challenges. Ann Allergy Asthma Immunol. 2015;114:319–26. One of the largest studies to date evaluating the utility of basophil activation testing versus traditional skin prick or serum IgE testing in the evaluation of food allergy.CrossRefPubMed
90.
go back to reference Santos AF, Du Toit G, Douiri A, Radulovic S, Stephens A, Turcanu V, et al. Distinct parameters of the basophil activation test reflect the severity and threshold of allergic reactions to peanut. J Allergy Clin Immunol. 2015;135:179–86.CrossRefPubMedPubMedCentral Santos AF, Du Toit G, Douiri A, Radulovic S, Stephens A, Turcanu V, et al. Distinct parameters of the basophil activation test reflect the severity and threshold of allergic reactions to peanut. J Allergy Clin Immunol. 2015;135:179–86.CrossRefPubMedPubMedCentral
91.
go back to reference Mullin GE, Swift KM, Lipski L, Turnbull LK, Rampertab SD. Testing for food reactions: the good, the bad, and the ugly. Nutr Clin Pract. 2010;25:192–8.CrossRefPubMed Mullin GE, Swift KM, Lipski L, Turnbull LK, Rampertab SD. Testing for food reactions: the good, the bad, and the ugly. Nutr Clin Pract. 2010;25:192–8.CrossRefPubMed
Metadata
Title
Pearls and Pitfalls in Diagnosing IgE-Mediated Food Allergy
Authors
David R. Stukus
Irene Mikhail
Publication date
01-05-2016
Publisher
Springer US
Published in
Current Allergy and Asthma Reports / Issue 5/2016
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-016-0611-z

Other articles of this Issue 5/2016

Current Allergy and Asthma Reports 5/2016 Go to the issue

Pediatric Allergy and Immunology (WK Dolen, Section Editor)

Food Allergy: Our Evolving Understanding of Its Pathogenesis, Prevention, and Treatment

Immune Deficiency and Dysregulation (DP Huston and C Kuo, Section Editors)

Gene Therapy for the Treatment of Primary Immune Deficiencies

Immune Deficiency and Dysregulation (DP Huston and C Kuo, Section Editors)

Epigenetic Dysfunction in Turner Syndrome Immune Cells

Pediatric Allergy and Immunology (WK Dolen, Section Editor)

Peanut Allergy: New Developments and Clinical Implications

Rhinosinusitis (J Mullol, Section Editor)

Olfaction in Chronic Rhinosinusitis