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01-09-2014 | Original Communication

Patterns of regional gray matter and white matter atrophy in cortical multiple sclerosis

Authors: Laura Parisi, Maria A. Rocca, Flavia Mattioli, Gianna C. Riccitelli, Ruggero Capra, Chiara Stampatori, Fabio Bellomi, Massimo Filippi

Published in: Journal of Neurology | Issue 9/2014

Abstract

We investigated the patterns of regional distribution of focal lesions, white matter (WM) and gray matter (GM) atrophy in patients with cortical (cort) MS in comparison to classical (c) MS patients. Nine cort-MS, nine c-MS and nine age-matched healthy controls (HC) underwent a brain MRI exam, including FLAIR and high-resolution T1-weighted scans. MS patients underwent neurological and neuropsychological assessment. Between-group differences of GM and WM volumes and their correlations with neuropsychological performances were assessed with voxel-based morphometry. FLAIR and T1 lesion probability maps (LPMs) were also obtained. Performance at neuropsychological tests was worse in cort-MS than in c-MS patients. Compared to HC, MS patients had a distributed pattern of GM and WM atrophy. No GM/WM area was more atrophic in c-MS vs cort-MS patients. Compared to c-MS, cort-MS patients experienced GM atrophy of frontal–temporal–parietal areas and cingulate cortex and WM atrophy of the cingulum bundle, bilateral cerebral peduncles, right inferior longitudinal fasciculus and left superior longitudinal fasciculus. FLAIR and T1 LPMs did not differ between c-MS vs cort-MS patients. A higher susceptibility to neurodegenerative processes in key brain regions known to be related to cognitive functions is likely to underlie the clinical manifestations of cort-MS.

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Title: Patterns of regional gray matter and white matter atrophy in cortical multiple sclerosis
Authors: Laura Parisi
Maria A. Rocca
Flavia Mattioli
Gianna C. Riccitelli
Ruggero Capra
Chiara Stampatori
Fabio Bellomi
Massimo Filippi
Publication date: 01-09-2014
Publisher: Springer Berlin Heidelberg
Published in: Journal of Neurology / Issue 9/2014
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-014-7409-5

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Patterns of regional gray matter and white matter atrophy in cortical multiple sclerosis

Abstract

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Abstract

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