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01-05-2011 | Original Article

Patterns of Pancreatic Resection Differ Between Patients with Familial and Sporadic Pancreatic Cancer

Authors: Joshua G. Barton, Thomas Schnelldorfer, Christine M. Lohse, William R. Bamlet, Kari G. Rabe, Gloria M. Petersen, John H. Donohue, Michael B. Farnell, Michael L. Kendrick, David M. Nagorney, Kay M. Reid Lombardo, Florencia G. Que

Published in: Journal of Gastrointestinal Surgery | Issue 5/2011

Abstract

Background

Although the increased risk of developing pancreatic cancer (PC) in families with a strong history of the disease is well known, characteristics and outcomes of patients with familial PC is not described well.

Aims

This study aims to evaluate outcomes following resection in patients with familial PC.

Methods

We studied 208 patients who underwent resection of PC from 2000 to 2007 and had prospectively completed family history questionnaires for the Biospecimen Resource for Pancreas Research at our institution. We compared clinical characteristics and outcomes of familial and sporadic PC patients.

Results

Familial (N = 15) and sporadic PC patients (N = 193) did not have significantly different demographics, pre-operative CA19-9, pre-operative weight loss, R0 status, or T-staging (all p ≥ 0.05). Familial PC patients had lower pre-operative total serum bilirubin concentrations (p = 0.03) and lesions outside of the pancreatic head more frequently (p = 0.02) than sporadic PC patients. There was no difference in survival at 2 years between familial and sporadic PC patients (p = 0.52).

Conclusions

Familial PC patients appear to develop tumors outside of the pancreatic head more frequently than sporadic PC patients. This difference in tumor distribution may be due to a broader area of cancer susceptibility within the pancreas for familial PC patients.

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Title: Patterns of Pancreatic Resection Differ Between Patients with Familial and Sporadic Pancreatic Cancer
Authors: Joshua G. Barton
Thomas Schnelldorfer
Christine M. Lohse
William R. Bamlet
Kari G. Rabe
Gloria M. Petersen
John H. Donohue
Michael B. Farnell
Michael L. Kendrick
David M. Nagorney
Kay M. Reid Lombardo
Florencia G. Que
Publication date: 01-05-2011
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 5/2011
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-011-1417-x

At a glance: The STEP trials

Springer Medicine

Patterns of Pancreatic Resection Differ Between Patients with Familial and Sporadic Pancreatic Cancer

Abstract

Background

Aims

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Aims

Methods

Results

Conclusions

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