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Journal of Neuro-Oncology

Published in:

01-07-2007 | Original Paper

Pattern of recurrence in paediatric malignant glioma: an institutional experience

Authors: Sucheta J. Vaidya, Darren Hargrave, Frank Saran, Juliet Britton, Rubin Soomal, Eric Bouffet

Published in: Journal of Neuro-Oncology | Issue 3/2007

Abstract

Background:

The purpose of this retrospective study was to investigate the pattern of recurrence in paediatric malignant gliomas.

Material and methods: We reviewed the notes, diagnostic imaging and treatment charts of 30 consecutive paediatric patients (age less than 18 years at diagnosis, range 0.5–17 years) presenting with a malignant glioma presenting to the paediatric oncology unit at the Royal Marsden Hospital over a 10-year period. The imaging at the time of first relapse was compared with the initial diagnostic scans to define a relapse as local, marginal or distant.

Results:

Median follow-up was 13 months (range 1–99 months). Twenty-four of 30 patients (80%) showed evidence of progression with a median time to progression of 8.5 months (range 3–64 months). Thirteen out of 24 patients developed local or marginal recurrences while 11/24 patients recurred at distant sites as site of first relapse (46%).

Conclusion:

Our series suggests that the pattern of relapses in paediatric malignant gliomas could be different from that reported in adult studies as we observed a significant incidence of distant relapses. Larger prospective series need to be conducted to investigate the clinico-biological characteristics of the population at high risk for leptomeningeal dissemination.

Arita N, Taneda M, Hayakawa T (1994) Leptomeningeal dissemination of malignant gliomas. Incidence, diagnosis and outcome. Acta Neurochir (Wien) 126:84–92CrossRef

Awad I, Bay JW, Rogers L (1986) Leptomeningeal metastasis from supratentorial malignant gliomas. Neurosurgery 19:247–251PubMedCrossRef

Bauman GS, Fisher BJ, Cairncross JG et al (1998) Bihemispheric malignant glioma: one size does not fit all. J Neurooncol 38:83–89PubMedCrossRef

Benesch M, Wagner S, Berthold F et al (2005) Primary dissemination of high-grade gliomas in children: experiences from four studies of the Pediatric Oncology and Hematology Society of the German Language Group (GPOH). J Neurooncol 72:179–183PubMedCrossRef

Bouffet E, Khelfaoui F, Philip I et al (1997) High-dose carmustine for high-grade gliomas in childhood. Cancer Chemother Pharmacol 39:376–379PubMedCrossRef

Bouffet E, Mottolese C, Jouvet A et al (1997) Etoposide and thiotepa followed by ABMT (autologous bone marrow transplantation) in children and young adults with high-grade gliomas. Eur J Cancer 33:91–95PubMedCrossRef

Donahue B, Allen J, Siffert J et al (1998) Patterns of recurrence in brain stem gliomas: evidence for craniospinal dissemination. Int J Radiat Oncol Biol Phys 40:677–680PubMedCrossRef

Dropcho EJ, Wisoff JH, Walker RW et al (1987) Supratentorial malignant gliomas in childhood: a review of fifty cases. Ann Neurol 22:355–364PubMedCrossRef

Duffner PK, Krischer JP, Burger PC et al (1996) Treatment of infants with malignant gliomas: the pediatric oncology group experience. J Neurooncol 28:245–256PubMedCrossRef

10.

Finlay JL, August C, Packer R et al (1990) High-dose multi-agent chemotherapy followed by bone marrow ‘rescue’ for malignant astrocytomas of childhood and adolescence. J Neurooncol 9:239–248PubMedCrossRef

11.

Finlay JL, Boyett JM, Yates AJ et al (1995) Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine, and prednisone with the eight-drugs-in-1-day regimen. Childrens Cancer Group. J Clin Oncol 13:112–123

12.

Finlay JL, Geyer JR, Turski PA et al (1994) Pre-irradiation chemotherapy in children with high-grade astrocytoma: tumor response to two cycles of the ‘8-drugs-in-1-day’ regimen. A Childrens Cancer Group study, CCG-945. J Neurooncol 21:255–265

13.

Fisher PG, Kadan-Lottick NS, Korones DN (2002) Intrathecal thiotepa: reappraisal of an established therapy. J Pediatr Hematol Oncol 24:274–278PubMedCrossRef

14.

Gaspar LE, Fisher BJ, Macdonald DR et al (1992) Supratentorial malignant glioma: patterns of recurrence and implications for external beam local treatment. Int J Radiat Oncol Biol Phys 24:55–57PubMed

15.

Grabb PA, Albright AL, Pang D (1992) Dissemination of supratentorial malignant gliomas via the cerebrospinal fluid in children. Neurosurgery 30:64–71PubMedCrossRef

16.

Gururangan S, McLaughlin CA, Brashears J et al (2006) Incidence and patterns of neuraxis metastases in children with diffuse pontine glioma( bigstar). J Neurooncol 77:207–212PubMedCrossRef

17.

Heideman RL, Kuttesch J Jr, Gajjar AJ et al (1997) Supratentorial malignant gliomas in childhood: a single institution perspective. Cancer 80:497–504PubMedCrossRef

18.

Laperriere N, Zuraw L, Cairncross G (2002) Radiotherapy for newly diagnosed malignant glioma in adults: a systematic review. Radiother Oncol 64:259–273PubMedCrossRef

19.

Massimino M, Gandola L, Luksch R et al (2005) Sequential chemotherapy, high-dose thiotepa, circulating progenitor cell rescue, and radiotherapy for childhood high-grade glioma. Neuro-oncol 7:41–48PubMedCrossRef

20.

Medical Research Council Brain Tumour Working Party (1990) Prognostic factors for high-grade malignant glioma: development of a prognostic index. A Report of the Medical Research Council Brain Tumour Working Party. J Neurooncol 9:47–55

21.

Parsa AT, Wachhorst S, Lamborn KR et al (2005) Prognostic significance of intracranial dissemination of glioblastoma multiforme in adults. J Neurosurg 102:622–628PubMedCrossRef

22.

Pollack IF, Finkelstein SD, Woods J et al (2002) Expression of p53 and prognosis in children with malignant gliomas. N Engl J Med 346:420–427PubMedCrossRef

23.

Shapiro WR, Green SB, Burger PC et al (1989) Randomized trial of three chemotherapy regimens and two radiotherapy regimens and two radiotherapy regimens in postoperative treatment of malignant glioma. Brain Tumor Cooperative Group Trial 8001. J Neurosurg 71:1–9

24.

Slavc I, Schuller E, Czech T et al (1998) Intrathecal mafosfamide therapy for pediatric brain tumors with meningeal dissemination. J Neurooncol 38:213–218PubMedCrossRef

25.

Sposto R, Ertel IJ, Jenkin RD et al (1989) The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: results of a randomized trial. A report from the Childrens Cancer Study Group. J Neurooncol 7:165–177

26.

Stupp R, Mason WP, van den Bent MJ et al (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987–996PubMedCrossRef

27.

Vertosick FT Jr, Selker RG (1990) Brain stem and spinal metastases of supratentorial glioblastoma multiforme: a clinical series. Neurosurgery 27:516–521PubMedCrossRef

28.

Wisoff JH, Boyett JM, Berger MS et al (1998) Current neurosurgical management and the impact of the extent of resection in the treatment of malignant gliomas of childhood: a report of the Children’s Cancer Group trial no. CCG-945. J Neurosurg 89:52–59CrossRef

29.

Witham TF, Fukui MB, Meltzer CC et al (1999) Survival of patients with high grade glioma treated with intrathecal thiotriethylenephosphoramide for ependymal or leptomeningeal gliomatosis. Cancer 86:1347–1353PubMedCrossRef

30.

Wolff JE, Gnekow AK, Kortmann RD et al (2002) Preradiation chemotherapy for pediatric patients with high-grade glioma. Cancer 94:264–271PubMedCrossRef

Title: Pattern of recurrence in paediatric malignant glioma: an institutional experience
Authors: Sucheta J. Vaidya
Darren Hargrave
Frank Saran
Juliet Britton
Rubin Soomal
Eric Bouffet
Publication date: 01-07-2007
Publisher: Kluwer Academic Publishers-Plenum Publishers
Published in: Journal of Neuro-Oncology / Issue 3/2007
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-006-9313-z

2024 ASCO Annual Meeting

Springer Medicine

Pattern of recurrence in paediatric malignant glioma: an institutional experience

Abstract

Background:

Results:

Conclusion:

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background:

Results:

Conclusion:

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