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Indian Journal of Pediatrics

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01-10-2015 | Original Article

Pattern of Gross Congenital Malformations in a Tertiary Referral Hospital in Northeast India

Authors: Jenita Baruah, Giriraj Kusre, Reeta Bora

Published in: Indian Journal of Pediatrics | Issue 10/2015

Abstract

Objective

To explore the prevalence of structural congenital malformations among newborns and study some of the fetal and maternal characteristics of the malformed babies in North east India where such systematic study on congenital malformation has not been undertaken before.

Methods

A cross sectional study was undertaken from May 2010 through Feb 2013 for estimation of gross congenital malformations among live birth and stillbirth children born in Assam Medical College. All live births were clinically examined for detection of gross congenital malformations and autopsy was carried out on still births and neonates dying within 24 h of birth to detect gross congenital malformations in the internal organs. All malformations were classified as per ICD 10 classification. The mothers of the newborns with congenital malformations were interviewed in a predesigned, pretested proforma. The variables included maternal age, antenatal registration, antenatal history of drug intake, consanguinity and previous history of malformations. Statistical analysis was done using chi square test.

Results

A total 18,192 births including live births and still births were examined and 206 cases of structural malformations were observed. Prevalence of congenital malformations was 1.2 % of the total live births. Distribution of malformation was predominant among males than in females (60.67 vs. 37.37 %; p < 0.05). Musculoskeletal system was the most common system involved. Prevalence of malformation of the cardiovascular system was found to be very low. Malformations among stillbirths and newborns born to unregistered mothers were significantly more. Percentage of malformations in babies born to mothers of more than 30 y of age was higher than other age groups (2.2 %). Occurrence of malformations in low birth weight babies were significantly more (p < 0.001).

Conclusions

Prevalence of malformations was 1.2 % of the total live births. Musculoskeletal system was the most common system involved. Congenital malformations were significantly associated with sex of the new born, registration of the mother and birth weight of the newborn.

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Title: Pattern of Gross Congenital Malformations in a Tertiary Referral Hospital in Northeast India
Authors: Jenita Baruah
Giriraj Kusre
Reeta Bora
Publication date: 01-10-2015
Publisher: Springer India
Published in: Indian Journal of Pediatrics / Issue 10/2015
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI: https://doi.org/10.1007/s12098-014-1685-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Pattern of Gross Congenital Malformations in a Tertiary Referral Hospital in Northeast India

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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