Skip to main content
Top
Published in: Surgical Endoscopy 12/2014

01-12-2014

Patient-reported outcomes of symptomatic cholelithiasis patients following cholecystectomy after at least 5 years of follow-up

A long-term prospective cohort study

Authors: Mark P. Lamberts, Brenda L. Den Oudsten, Frederik Keus, Jolanda De Vries, Cornelis J. H. M. van Laarhoven, Gert P. Westert, Joost P. H. Drenth, Jan A. Roukema

Published in: Surgical Endoscopy | Issue 12/2014

Login to get access

Abstract

Background

Up to 41 % of patients report pain after cholecystectomy and in most studies follow-up for these symptoms did not exceed 5 years. The episodic nature of abdominal pain associated with symptomatic cholelithiasis warrants long-term follow-up studies. We assessed which patient and surgical factors were associated with absence of pain and patient-reported success of surgery after ≥5 years of follow-up.

Methods

Patients of ≥18 years of age with symptomatic cholelithiasis, classified as ASA I or II, who had previously returned a preoperative questionnaire were sent a questionnaire consisting of the gastrointestinal quality of life index (GIQLI) and patient ratings of current versus presurgical abdominal symptoms and of surgery result. Logistic regression analysis was performed to determine associations.

Results

Questionnaires were sent to 197 patients and returned by 126 (64.0 %) patients (73.8 % female, mean age at surgery 47.5 ± 12.2 years) at a mean of 10.0 ± 1.0 years after cholecystectomy. Absence of abdominal pain was reported by 60.3 % of the patients. Patients classified as ASA II as opposed to ASA I were less likely to report absence of pain (OR 0.41, 95 % CI 0.17–0.99). A positive rating of long-term postsurgical versus presurgical abdominal symptoms was given by 89.7 % of the patients and 90.5 % considered the cholecystectomy result to be good. No variables were significantly associated with these latter two outcome measures.

Conclusions

We found a high patient-reported surgery success rate after >5 years of follow-up after cholecystectomy despite residual abdominal pain in some of these patients. None of the patient and surgery-related characteristics were consistently associated with all three outcome measures. This discrepancy between patient’ outcomes highlights the need for realistic expectations prior to cholecystectomy.
Literature
1.
go back to reference Everhart JE, Ruhl CE (2009) Burden of digestive diseases in the United States Part III: liver, biliary tract, and pancreas. Gastroenterology 136:1134–1144PubMedCrossRef Everhart JE, Ruhl CE (2009) Burden of digestive diseases in the United States Part III: liver, biliary tract, and pancreas. Gastroenterology 136:1134–1144PubMedCrossRef
2.
go back to reference Shaffer EA (2006) Gallstone disease: epidemiology of gallbladder stone disease. Best Pract Res Clin Gastroenterol 20:981–996PubMedCrossRef Shaffer EA (2006) Gallstone disease: epidemiology of gallbladder stone disease. Best Pract Res Clin Gastroenterol 20:981–996PubMedCrossRef
3.
go back to reference Halldestam I, Enell EL, Kullman E, Borch K (2004) Development of symptoms and complications in individuals with asymptomatic gallstones. Br j surg 91:734–738PubMedCrossRef Halldestam I, Enell EL, Kullman E, Borch K (2004) Development of symptoms and complications in individuals with asymptomatic gallstones. Br j surg 91:734–738PubMedCrossRef
5.
go back to reference Wittenburg H (2010) Hereditary liver disease: gallstones. Best Pract Res Clin Gastroenterol 24:747–756PubMedCrossRef Wittenburg H (2010) Hereditary liver disease: gallstones. Best Pract Res Clin Gastroenterol 24:747–756PubMedCrossRef
6.
go back to reference Everhart JE, Ruhl CE (2009) Burden of digestive diseases in the United States part I: overall and upper gastrointestinal diseases. Gastroenterology 136:376–386PubMedCrossRef Everhart JE, Ruhl CE (2009) Burden of digestive diseases in the United States part I: overall and upper gastrointestinal diseases. Gastroenterology 136:376–386PubMedCrossRef
7.
go back to reference Jones C, Mawhinney A, Brown R (2012) The true cost of gallstone disease. Ulst med J 81:10–13 Jones C, Mawhinney A, Brown R (2012) The true cost of gallstone disease. Ulst med J 81:10–13
8.
go back to reference Keus F, de Jonge T, Gooszen HG, Buskens E, van Laarhoven CJ (2009) Cost-minimization analysis in a blind randomized trial on small-incision versus laparoscopic cholecystectomy from a societal perspective: sick leave outweighs efforts in hospital savings. Trials 10:80PubMedCentralPubMedCrossRef Keus F, de Jonge T, Gooszen HG, Buskens E, van Laarhoven CJ (2009) Cost-minimization analysis in a blind randomized trial on small-incision versus laparoscopic cholecystectomy from a societal perspective: sick leave outweighs efforts in hospital savings. Trials 10:80PubMedCentralPubMedCrossRef
9.
go back to reference Lamberts MP, Lugtenberg M, Rovers MM, Roukema AJ, Drenth JP, Westert GP, van Laarhoven CJ (2013) Persistent and de novo symptoms after cholecystectomy: a systematic review of cholecystectomy effectiveness. Surg Endosc 27:709–718PubMedCrossRef Lamberts MP, Lugtenberg M, Rovers MM, Roukema AJ, Drenth JP, Westert GP, van Laarhoven CJ (2013) Persistent and de novo symptoms after cholecystectomy: a systematic review of cholecystectomy effectiveness. Surg Endosc 27:709–718PubMedCrossRef
10.
go back to reference Thistle JL, Longstreth GF, Romero Y, Arora AS, Simonson JA, Diehl NN, Harmsen WS, Zinsmeister AR (2011) Factors that predict relief from upper abdominal pain after cholecystectomy. Clin Gastroenterol Hepatol 9:891–896PubMedCrossRef Thistle JL, Longstreth GF, Romero Y, Arora AS, Simonson JA, Diehl NN, Harmsen WS, Zinsmeister AR (2011) Factors that predict relief from upper abdominal pain after cholecystectomy. Clin Gastroenterol Hepatol 9:891–896PubMedCrossRef
11.
go back to reference Ahmed R, Freeman JV, Ross B, Kohler B, Nicholl JP, Johnson AG (2000) Long term response to gallstone treatment–problems and surprises. Eur J surg 166:447–454PubMedCrossRef Ahmed R, Freeman JV, Ross B, Kohler B, Nicholl JP, Johnson AG (2000) Long term response to gallstone treatment–problems and surprises. Eur J surg 166:447–454PubMedCrossRef
12.
go back to reference Konsten J, Gouma DJ, von Meyenfeldt MF, Menheere P (1993) Long-term follow-up after open cholecystectomy. Br J surg 80:100–102PubMedCrossRef Konsten J, Gouma DJ, von Meyenfeldt MF, Menheere P (1993) Long-term follow-up after open cholecystectomy. Br J surg 80:100–102PubMedCrossRef
13.
go back to reference Sand J, Pakkala S, Nordback I (1996) Twenty to thirty year follow-up after cholecystectomy. Hepatogastroenterology 43:534–537PubMed Sand J, Pakkala S, Nordback I (1996) Twenty to thirty year follow-up after cholecystectomy. Hepatogastroenterology 43:534–537PubMed
14.
go back to reference Schmidt M, Sondenaa K, Vetrhus M, Berhane T, Eide GE (2011) A randomized controlled study of uncomplicated gallstone disease with a 14-year follow-up showed that operation was the preferred treatment. Dig Surgery 28:270–276CrossRef Schmidt M, Sondenaa K, Vetrhus M, Berhane T, Eide GE (2011) A randomized controlled study of uncomplicated gallstone disease with a 14-year follow-up showed that operation was the preferred treatment. Dig Surgery 28:270–276CrossRef
15.
go back to reference Vetrhus M, Berhane T, Soreide O, Sondenaa K (2005) Pain persists in many patients five years after removal of the gallbladder: observations from two randomized controlled trials of symptomatic, noncomplicated gallstone disease and acute cholecystitis. J Gastrointest Surg 9:826–831PubMedCrossRef Vetrhus M, Berhane T, Soreide O, Sondenaa K (2005) Pain persists in many patients five years after removal of the gallbladder: observations from two randomized controlled trials of symptomatic, noncomplicated gallstone disease and acute cholecystitis. J Gastrointest Surg 9:826–831PubMedCrossRef
16.
go back to reference Fisher ES, Wennberg DE, Stukel TA, Gottlieb DJ, Lucas FL, Pinder EL (2003) The implications of regional variations in medicare spending. Part 2: health outcomes and satisfaction with care. Ann Intern Med 138:288–298PubMedCrossRef Fisher ES, Wennberg DE, Stukel TA, Gottlieb DJ, Lucas FL, Pinder EL (2003) The implications of regional variations in medicare spending. Part 2: health outcomes and satisfaction with care. Ann Intern Med 138:288–298PubMedCrossRef
17.
go back to reference Fisher ES, Wennberg DE, Stukel TA, Gottlieb DJ, Lucas FL, Pinder EL (2003) The implications of regional variations in medicare spending. Part 1: the content, quality, and accessibility of care. Ann Intern Med 138:273–287PubMedCrossRef Fisher ES, Wennberg DE, Stukel TA, Gottlieb DJ, Lucas FL, Pinder EL (2003) The implications of regional variations in medicare spending. Part 1: the content, quality, and accessibility of care. Ann Intern Med 138:273–287PubMedCrossRef
18.
go back to reference Harrison EM, O’Neill S, Meurs TS, Wong PL, Duxbury M, Paterson-Brown S, Wigmore SJ, Garden OJ (2012) Hospital volume and patient outcomes after cholecystectomy in Scotland: retrospective, national population based study. BMJ 344:e3330PubMedCrossRef Harrison EM, O’Neill S, Meurs TS, Wong PL, Duxbury M, Paterson-Brown S, Wigmore SJ, Garden OJ (2012) Hospital volume and patient outcomes after cholecystectomy in Scotland: retrospective, national population based study. BMJ 344:e3330PubMedCrossRef
19.
go back to reference Keus F, de Vries J, Gooszen HG, van Laarhoven CJ (2008) Laparoscopic versus small-incision cholecystectomy: health status in a blind randomised trial. Surg Endosc 22:1649–1659PubMedCentralPubMedCrossRef Keus F, de Vries J, Gooszen HG, van Laarhoven CJ (2008) Laparoscopic versus small-incision cholecystectomy: health status in a blind randomised trial. Surg Endosc 22:1649–1659PubMedCentralPubMedCrossRef
20.
go back to reference Eypasch E, Williams JI, Wood-Dauphinee S, Ure BM, Schmulling C, Neugebauer E, Troidl H (1995) Gastrointestinal Quality of Life Index: development, validation and application of a new instrument. Br J Surg 82:216–222PubMedCrossRef Eypasch E, Williams JI, Wood-Dauphinee S, Ure BM, Schmulling C, Neugebauer E, Troidl H (1995) Gastrointestinal Quality of Life Index: development, validation and application of a new instrument. Br J Surg 82:216–222PubMedCrossRef
21.
go back to reference Nieveen Van Dijkum EJ, Terwee CB, Oosterveld P, Van Der Meulen JH, Gouma DJ, De Haes JC (2000) Validation of the gastrointestinal quality of life index for patients with potentially operable periampullary carcinoma. Br J Surg 87:110–115PubMedCrossRef Nieveen Van Dijkum EJ, Terwee CB, Oosterveld P, Van Der Meulen JH, Gouma DJ, De Haes JC (2000) Validation of the gastrointestinal quality of life index for patients with potentially operable periampullary carcinoma. Br J Surg 87:110–115PubMedCrossRef
22.
23.
24.
go back to reference von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP, Initiative S (2008) The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol 61:344–349CrossRef von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP, Initiative S (2008) The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol 61:344–349CrossRef
25.
go back to reference Quintana JM, Cabriada J, Arostegui I, Oribe V, Perdigo L, Varona M, Bilbao A (2005) Health-related quality of life and appropriateness of cholecystectomy. Ann Surg 241:110–118PubMedCentralPubMed Quintana JM, Cabriada J, Arostegui I, Oribe V, Perdigo L, Varona M, Bilbao A (2005) Health-related quality of life and appropriateness of cholecystectomy. Ann Surg 241:110–118PubMedCentralPubMed
26.
go back to reference Weinert CR, Arnett D, Jacobs D Jr, Kane RL (2000) Relationship between persistence of abdominal symptoms and successful outcome after cholecystectomy. Arch Intern Med 160:989–995PubMedCrossRef Weinert CR, Arnett D, Jacobs D Jr, Kane RL (2000) Relationship between persistence of abdominal symptoms and successful outcome after cholecystectomy. Arch Intern Med 160:989–995PubMedCrossRef
27.
go back to reference Bitzer EM, Lorenz C, Nickel S, Dorning H, Trojan A (2008) Assessing patient-reported outcomes of cholecystectomy in short-stay surgery. Surg Endosc 22:2712–2719PubMedCrossRef Bitzer EM, Lorenz C, Nickel S, Dorning H, Trojan A (2008) Assessing patient-reported outcomes of cholecystectomy in short-stay surgery. Surg Endosc 22:2712–2719PubMedCrossRef
28.
go back to reference Zapf M, Denham W, Barrera E, Butt Z, Carbray J, Wang C, Linn J, Ujiki M (2013) Patient-centered outcomes after laparoscopic cholecystectomy. Surg Endosc 27:4491–4498PubMedCrossRef Zapf M, Denham W, Barrera E, Butt Z, Carbray J, Wang C, Linn J, Ujiki M (2013) Patient-centered outcomes after laparoscopic cholecystectomy. Surg Endosc 27:4491–4498PubMedCrossRef
29.
go back to reference Festi D, Reggiani ML, Attili AF, Loria P, Pazzi P, Scaioli E, Capodicasa S, Romano F, Roda E, Colecchia A (2010) Natural history of gallstone disease: expectant management or active treatment? Results from a population-based cohort study. J Gastroenterol Hepatol 25:719–724PubMedCrossRef Festi D, Reggiani ML, Attili AF, Loria P, Pazzi P, Scaioli E, Capodicasa S, Romano F, Roda E, Colecchia A (2010) Natural history of gallstone disease: expectant management or active treatment? Results from a population-based cohort study. J Gastroenterol Hepatol 25:719–724PubMedCrossRef
30.
go back to reference Turner JA, Deyo RA, Loeser JD, Von Korff M, Fordyce WE (1994) The importance of placebo effects in pain treatment and research. JAMA 271:1609–1614PubMedCrossRef Turner JA, Deyo RA, Loeser JD, Von Korff M, Fordyce WE (1994) The importance of placebo effects in pain treatment and research. JAMA 271:1609–1614PubMedCrossRef
31.
go back to reference American College of P (2008) Information on cost-effectiveness: an essential product of a national comparative effectiveness program. Ann Intern Med 148:956–961CrossRef American College of P (2008) Information on cost-effectiveness: an essential product of a national comparative effectiveness program. Ann Intern Med 148:956–961CrossRef
Metadata
Title
Patient-reported outcomes of symptomatic cholelithiasis patients following cholecystectomy after at least 5 years of follow-up
A long-term prospective cohort study
Authors
Mark P. Lamberts
Brenda L. Den Oudsten
Frederik Keus
Jolanda De Vries
Cornelis J. H. M. van Laarhoven
Gert P. Westert
Joost P. H. Drenth
Jan A. Roukema
Publication date
01-12-2014
Publisher
Springer US
Published in
Surgical Endoscopy / Issue 12/2014
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-014-3619-2

Other articles of this Issue 12/2014

Surgical Endoscopy 12/2014 Go to the issue