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Journal of Experimental & Clinical Cancer Research
Published in: Journal of Experimental & Clinical Cancer Research 1/2016

Open Access 01-12-2016 | Review

Patient-derived xenografts: a relevant preclinical model for drug development

Authors: Luca Pompili, Manuela Porru, Carla Caruso, Annamaria Biroccio, Carlo Leonetti

Published in: Journal of Experimental & Clinical Cancer Research | Issue 1/2016

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Abstract

Identifying appropriate preclinical cancer models remains a major challenge in increasing the efficiency of drug development. A potential strategy to improve patient outcomes could be selecting the ‘right’ treatment in preclinical studies performed in patient-derived xenografts (PDXs) obtained by direct implants of surgically resected tumours in mice. These models maintain morphological similarities and recapitulate molecular profiling of the original tumours, thus representing a useful tool in evaluating anticancer drug response. In this review, we will present the state-of-art use of PDXs as a reliable strategy to predict clinical findings. The main advantages and limitations will also be discussed.
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Metadata
Title
Patient-derived xenografts: a relevant preclinical model for drug development
Authors
Luca Pompili
Manuela Porru
Carla Caruso
Annamaria Biroccio
Carlo Leonetti
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Journal of Experimental & Clinical Cancer Research / Issue 1/2016
Electronic ISSN: 1756-9966
DOI
https://doi.org/10.1186/s13046-016-0462-4

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