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01-01-2016 | 2015 SSAT Plenary Presentation

Pathophysiology of Gastroesophageal Reflux in Patients with Chronic Pulmonary Obstructive Disease Is Linked to an Increased Transdiaphragmatic Pressure Gradient and not to a Defective Esophagogastric Barrier

Authors: Leonardo M. Del Grande, Fernando A. M. Herbella, Amilcar M. Bigatao, Henrique Abrao, Jose R. Jardim, Marco G. Patti

Published in: Journal of Gastrointestinal Surgery | Issue 1/2016

Excerpt

The association of gastroesophageal reflux disease (GERD) and pulmonary diseases is well known.1 Early studies showed that gastroduodenal contents may reflux up to the proximal esophagus2 and cause aspiration.3 Other studies showed a higher incidence of GERD in patients with asthma,4 interstitial fibrosis,5 chronic cough,6 and chronic obstructive pulmonary disease (COPD).7‐10 …

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Sweet MP, Patti MG, Hoopes C, Hays SR, Golden JA. Gastro-oesophageal reflux and aspiration in patients with advanced lung disease. Thorax. 2009 Feb;64(2):167–73

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Allaix ME, Fisichella PM, Noth I, Herbella FA, Borraez Segura B, Patti MG. Idiopathic pulmonary fibrosis and gastroesophageal reflux. Implications for treatment. J Gastrointest Surg. 2014 Jan;18(1):100–5.

Kahrilas PJ, Smith JA, Dicpinigaitis PV. A Causal Relationship Between Cough and Gastroesophageal Reflux Disease (GERD) has been Established: A Pro/Con Debate. Lung. 2014 Feb;192(1):39–46.

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Johnson LF, Demeester TR. Twenty-four-hour pH monitoring of the distal esophagus. A quantitative measure of gastroesophageal reflux. Am J Gastroenterol. 1974 Oct;62(4):325–32.

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Neto SC, Herbella FA, Silva LC, Patti MG. Ratio Between Proximal/Distal Gastroesophageal Reflux Does Not Discriminate Abnormal Proximal Reflux. World J Surg. 2014 Apr. 38(4):890–896.

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Bello B, Zoccali M, Gullo R, Allaix ME, Herbella FA, Gasparaitis A, Patti MG. Gastroesophageal reflux disease and antireflux surgery-what is the proper preoperative work-up? J Gastrointest Surg. 2013 Jan;17(1):14–20: discussion p. 20.

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Title: Pathophysiology of Gastroesophageal Reflux in Patients with Chronic Pulmonary Obstructive Disease Is Linked to an Increased Transdiaphragmatic Pressure Gradient and not to a Defective Esophagogastric Barrier
Authors: Leonardo M. Del Grande
Fernando A. M. Herbella
Amilcar M. Bigatao
Henrique Abrao
Jose R. Jardim
Marco G. Patti
Publication date: 01-01-2016
Publisher: Springer US
Published in: Journal of Gastrointestinal Surgery / Issue 1/2016
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-015-2955-4

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Pathophysiology of Gastroesophageal Reflux in Patients with Chronic Pulmonary Obstructive Disease Is Linked to an Increased Transdiaphragmatic Pressure Gradient and not to a Defective Esophagogastric Barrier

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Keynote webinar | Spotlight on medication adherence

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