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Indian Journal of Otolaryngology and Head & Neck Surgery

Published in:

20-12-2023 | Pathology | Original Article

Role of CD34-immunopositive Microvascular Density in Juvenile Nasopharyngeal Angiofibroma

Authors: Avinash Shekhar Jaiswal, Rakesh Kumar, Aanchal Kakkar, Rajeev Kumar, Hitesh Verma, Ashu Seith Bhalla, Arvind Kumar Kairo, Alok Thakar

Published in: Indian Journal of Otolaryngology and Head & Neck Surgery | Issue 2/2024

Abstract

Objective

To assess the microvascular density (MVD) in juvenile nasopharyngeal angiofibroma (JNA) with CD34 immunostaining and evaluate its relationship with clinico-demographic features.

Methods

This prospective study included patients with JNA undergoing endoscopic excision. The histopathological specimen was stained using CD-34 antibodies to calculate MVD. MVD and clinico-demographic features were correlated.

Results

The study included 12 patients with a median age of 15.5 years. The mean MVD was 39 vessels/high power field (range 5 to 151 vessels). MVD was significantly associated only with the volume of tumour (r = 0.65, p = 0.02). The recurrence occurred in one patient with an MVD of 107. The median follow-up was 38 months.

Conclusion

MVD is significantly associated with tumour volume in JNA, which implies a robust role of angiogenesis in the pathology of the tumour. Also, higher MVD may be a risk factor for recurrence.

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Title: Role of CD34-immunopositive Microvascular Density in Juvenile Nasopharyngeal Angiofibroma
Authors: Avinash Shekhar Jaiswal
Rakesh Kumar
Aanchal Kakkar
Rajeev Kumar
Hitesh Verma
Ashu Seith Bhalla
Arvind Kumar Kairo
Alok Thakar
Publication date: 20-12-2023
Publisher: Springer India
Keyword: Pathology
Published in: Indian Journal of Otolaryngology and Head & Neck Surgery / Issue 2/2024
Print ISSN: 2231-3796
Electronic ISSN: 0973-7707
DOI: https://doi.org/10.1007/s12070-023-04331-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Role of CD34-immunopositive Microvascular Density in Juvenile Nasopharyngeal Angiofibroma

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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