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26-10-2023 | Pathology | Review Article

Theta-burst stimulation as a therapeutic tool in neurological pathology: a systematic review

Authors: Nicoleta Jemna, Ana Calina Zdrenghea, Georgiana Frunza, Anca Diana Demea, Gheorghe Elian Hapca, Diana Alecsandra Grad, Ioana Anamaria Muresanu, Razvan Mircea Chereches, Fior Dafin Muresanu

Published in: Neurological Sciences | Issue 3/2024

Abstract

TBS (theta-burst stimulation) is a novel therapeutic approach in a wide range of neurological diseases. The present systematic review aims to identify the various protocols used in the last years, to assess study quality and to offer a general overview of the current state of the literature. The systematic review was conducted according to the Preferred Reporting Item for Systematic Review and Meta-Analyses (PRISMA) guidelines. We applied the following inclusion criteria: (1) population over 18 years old with diagnosed neurological disorders, (2) patients treated with sessions of theta-burst stimulation, (3) randomized-controlled clinical trials, (4) articles in the English language, and (5) studies that report response and score reduction on a validated scale of the investigated disorder or remission rates. We included in the final analysis 56 randomized controlled trials focusing on different neurological pathologies (stroke, Parkinson`s disease, multiple sclerosis, tinnitus, dystonia, chronic pain, essential tremor and tic disorder), and we extracted data regarding study design, groups and comparators, sample sizes, type of coil, stimulation parameters (frequency, number of pulses, intensity, stimulation site etc.), number of sessions, follow-up, assessment through functional connectivity and neurological scales used. We observed a great interstudy heterogenicity that leads to a difficulty in drawing plain conclusions. TBS protocols have shown promising results in improving various symptoms in patients with neurological disorders, but larger and more coherent studies, using similar stimulation protocols and evaluation scales, are needed to establish guideline recommendations.

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Title: Theta-burst stimulation as a therapeutic tool in neurological pathology: a systematic review
Authors: Nicoleta Jemna
Ana Calina Zdrenghea
Georgiana Frunza
Anca Diana Demea
Gheorghe Elian Hapca
Diana Alecsandra Grad
Ioana Anamaria Muresanu
Razvan Mircea Chereches
Fior Dafin Muresanu
Publication date: 26-10-2023
Publisher: Springer International Publishing
Keywords: Pathology
Repetitive Transcranial Magnetic Stimulation
Transcranial Magnetic Stimulation
Transcranial Magnetic Stimulation
Tinnitus
Published in: Neurological Sciences / Issue 3/2024
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-023-07144-6

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Theta-burst stimulation as a therapeutic tool in neurological pathology: a systematic review

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Keynote webinar | Spotlight on medication adherence

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