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Immunologic Research
Published in: Immunologic Research 2-3/2014

01-05-2014 | IMMUNOLOGY AT STANFORD UNIVERSITY

Path to clinical transplantation tolerance and prevention of graft-versus-host disease

Author: Samuel Strober

Published in: Immunologic Research | Issue 2-3/2014

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Abstract

Although organ and bone marrow transplantations are life-saving procedures for patients with terminal diseases, the requirement for the lifelong use of immunosuppressive drugs to prevent organ graft rejection and the development of graft versus host disease (GVHD) remain important problems. Experimental approaches to solve these problems, first in preclinical models and then in clinical studies, developed at Stanford during the past 40 years are summarized in this article. The approaches use fractionated radiation of the lymphoid tissues, a procedure initially developed to treat Hodgkin’s disease, to alter the immune system such that tolerance to organ transplants can be achieved and GVHD can be prevented after the establishment of chimerism. In both instances, the desired goal was achieved when the balance of immune cells was changed to favor regulatory innate and adaptive immune cells that suppress the conventional immune cells that ordinarily promote inflammation and tissue injury.
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Metadata
Title
Path to clinical transplantation tolerance and prevention of graft-versus-host disease
Author
Samuel Strober
Publication date
01-05-2014
Publisher
Springer US
Published in
Immunologic Research / Issue 2-3/2014
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-014-8502-7

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