Top

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Published in:

Open Access 01-12-2021 | Parkinson's Disease | Research

Vitamin D receptor gene polymorphisms and idiopathic Parkinson disease: an Egyptian study

Authors: Ebtesam Mohamed Fahmy, Mohamed Elsayed Elawady, Sahar Sharaf, Sarah Heneidy, Rania Shehata Ismail

Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery | Issue 1/2021

Abstract

Background

Accumulating data have suggested that vitamin D receptor (VDR) gene is a pretender gene for vulnerability to Parkinson disease (PD). This study aimed to assess the relationship of VDR gene polymorphisms (FokI and ApaI) with PD. Fifty patients suffering from PD and 50 age- and sex-matched healthy controls were included. Unified Parkinson Disease Rating Scale (UPDRS) was done to assess disease severity. Genetic testing for VDR gene single nucleotide polymorphisms (FokI and ApaI) was done using real time polymerase chain reaction (PCR) technique.

Results

Concerning frequency of genes and alleles for vitamin D receptor gene polymorphisms (FokI and ApaI), no statistically significant difference was found between PD patients and controls. AC genotype was associated with younger age and younger age at onset of disease compared to CC and AA genotypes of ApaI gene polymorphisms. CC genotype was significantly positively correlated with fatigue and urine incontinence. VDR gene polymorphisms were not found to be independent predictors for severity of PD after adjustment for possible confounders.

Conclusion

VDR gene polymorphisms are related to the clinical manifestations rather than etiology or severity of idiopathic PD.

Morello M, Pieri M, Zenobi R, Talamo A, Stephan D, Landel V, et al. The influence of vitamin D on neurodegeneration and neurological disorders: a rationale for its physio-pathological actions. Current pharmaceutical design. 2020;26(21):2475–91. https://doi.org/10.2174/1381612826666200316145725.CrossRefPubMed

Taymans SE, Pack S, Pak E, Orban Z, Barsony J, Zhuang Z, et al. The Human vitamin D receptor gene (VDR) is localized to region 12cen-q12 by fluorescent in situ hybridization and radiation hybrid mapping: genetic and physical VDR map. J Bone Miner Res. 1999;14(7):1163–6. https://doi.org/10.1359/jbmr.1999.14.7.1163.CrossRefPubMed

Niu MY, Wang L, Xie AM. ApaI, BsmI, FokI, and TaqI polymorphisms in the vitamin D receptor gene and Parkinson’s disease. Chin Med J. 2015;128(13):1809–14. https://doi.org/10.4103/0366-6999.159358.CrossRefPubMedPubMedCentral

Butler MW, Burt A, Edwards TL, Zuchner S, Scott WK, Martin ER, et al. Vitamin D receptor gene as a candidate gene for Parkinson disease. Ann Hum Genet. 2011;75(2):201–10. https://doi.org/10.1111/j.1469-1809.2010.00631.x.CrossRefPubMedPubMedCentral

Lv Z, Tang B, Sun Q, Yan X, Guo J. Association study between vitamin d receptor gene polymorphisms and patients with Parkinson disease in Chinese Han population. Int J Neurosci. 2012;123(1):60–4. https://doi.org/10.3109/00207454.2012.726669.CrossRefPubMed

Török R, Török N, Szalardy L, Plangar I, Szolnoki Z, Somogyvari F, et al. Association of vitamin D receptor gene polymorphisms and Parkinson's disease in Hungarians. Neurosci Lett. 2013;551:70–4. https://doi.org/10.1016/j.neulet.2013.07.014.CrossRefPubMed

Lin CH, Chen KH, Chen ML, Lin HI, Wu RM. Vitamin D receptor genetic variants and Parkinson's disease in a Taiwanese population. Neurobiol Aging. 2014;35(5):1212–e11.CrossRef

Lv L, Tan X, Peng X, Bai R, Xiao Q, Zou T, et al. The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease. Transl Neurodegener. 2020;9(1):1–3.CrossRef

Gao J, Teng J, Liu Z, Cai M, Xie A. Association between vitamin D receptor polymorphisms and susceptibility to Parkinson's disease: an updated meta-analysis. Neurosci Lett. 2020;720:134778. https://doi.org/10.1016/j.neulet.2020.134778.CrossRefPubMed

10.

Fahn S. Members of the UPDRS development committee. Unified Parkinson’s disease rating scale. Recent Dev Parkinson’s Dis. 1987;2:293–304.

11.

Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez-Martin P, et al. Movement Disorder Society- sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord. 2008;23(15):2129–70.CrossRef

12.

Petersen MS, Bech S, Christiansen DH, Schmedes AV, Halling J. The role of vitamin D levels and vitamin D receptor polymorphism on Parkinson's disease in the Faroe Islands. Neurosci Lett. 2014;561:74–9. https://doi.org/10.1016/j.neulet.2013.12.053.CrossRefPubMed

13.

Gezen-Ak D, Alaylıoğlu M, Genç G, Gündüz A, Candaş E, Bilgiç B, et al. GC and VDR SNPs and vitamin D levels in Parkinson’s disease: the relevance to clinical features. Neuromolecular Med. 2017;19(1):24–40. https://doi.org/10.1007/s12017-016-8415-9.CrossRefPubMed

14.

Han X, Xue L, Li Y, Chen B, Xie A. Vitamin D receptor gene polymorphism and its association with Parkinson's disease in Chinese Han population. Neurosci Lett. 2012;525(1):29–33. https://doi.org/10.1016/j.neulet.2012.07.033.CrossRefPubMed

15.

Suzuki M, Yoshioka M, Hashimoto M, Murakami M, Kawasaki K, Noya M, et al. 25hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson's disease. Mov Disord. 2012;27(2):264–71. https://doi.org/10.1002/mds.24016.CrossRefPubMed

Title: Vitamin D receptor gene polymorphisms and idiopathic Parkinson disease: an Egyptian study
Authors: Ebtesam Mohamed Fahmy
Mohamed Elsayed Elawady
Sahar Sharaf
Sarah Heneidy
Rania Shehata Ismail
Publication date: 01-12-2021
Publisher: Springer Berlin Heidelberg
Keyword: Parkinson's Disease
Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery / Issue 1/2021
Electronic ISSN: 1687-8329
DOI: https://doi.org/10.1186/s41983-021-00358-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Vitamin D receptor gene polymorphisms and idiopathic Parkinson disease: an Egyptian study

Abstract

Background

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2021

How COVID-19 pandemic changed our management strategies for amyotrophic lateral sclerosis (ALS) patients: Egyptian study

The impact of clinical scales in Parkinson’s disease: a systematic review

Risk factors and impact of stigma on psychiatric patients in Sohag

Helicobacter pylori antibodies and multiple sclerosis: a single-center study and a short review of the literature

The relationship of HLA-G 14-bp insertion/deletion genetic polymorphism to the risk of multiple sclerosis and its clinical phenotypes

Copeptin: a potential blood biomarker for acute ischemic stroke