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27-03-2024 | Parkinson's Disease | Original Communication

Vestibular-evoked myogenic potential abnormalities in Parkinson’s disease with freezing of gait

Authors: Yuhan Jiang, Mengxi Zhou, Haibin Sheng, Shuai Xu, Yajing Chen, Li Wu, Qing He, Lei Zhao, Jianren Liu, Wei Chen

Abstract

Background

Vestibular dysfunction is closely associated with the pathophysiology of Parkinson’s disease (PD) accompanied by freezing of gait (FOG); however, evidence supporting this clinical association is lacking. Vestibular-evoked myogenic potentials (VEMPs) have been widely acknowledged as a crucial electrophysiological parameter in the clinical evaluation of vestibular function.

Objective

The present study investigated the possible correlation of FOG occurrence with VEMP observations in patients diagnosed with PD.

Methods

Altogether, 95 idiopathic PD patients were recruited into the present cross-sectional study. All patients underwent motor and non-motor assessments using serial scales. In addition, the electrophysiological vestibular evaluation was conducted, which included cervical (cVEMP) and ocular VEMP (oVEMP) assessments. Furthermore, the correlations of bilateral c/oVEMP absence with clinical phenotypes, especially FOG, among the PD patients were analyzed.

Results

Among the 95 patients with PD, 44 (46.3%) had bilateral oVEMP absence and 23 (24.2%) had bilateral cVEMP absence, respectively. The proportions of patients with bilateral oVEMP absence (77.8% vs 30.9%, p = 0.004) and bilateral cVEMP absence (44.4% vs 19.5%, p = 0.035) were higher in the patient group exhibiting FOG than in the group without FOG. Following the adjustment of confounding variables, bilateral oVEMP absence (OR = 8.544, p = 0.007), rather than bilateral cVEMP absence, was shown to independently predict FOG occurrence in patients with PD.

Conclusion

The close correlation between bilateral oVEMP absence and FOG in PD patients sheds new light on the possible role of central vestibular/upper brainstem dysfunction in FOG development in patients with PD.

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Title: Vestibular-evoked myogenic potential abnormalities in Parkinson’s disease with freezing of gait
Authors: Yuhan Jiang
Mengxi Zhou
Haibin Sheng
Shuai Xu
Yajing Chen
Li Wu
Qing He
Lei Zhao
Jianren Liu
Wei Chen
Publication date: 27-03-2024
Publisher: Springer Berlin Heidelberg
Keyword: Parkinson's Disease
Published in: Journal of Neurology
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-024-12311-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Vestibular-evoked myogenic potential abnormalities in Parkinson’s disease with freezing of gait

Abstract

Background

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Objective

Methods

Results

Conclusion

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