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01-08-2019 | Parkinson's Disease | Neurology and Preclinical Neurological Studies - Original Article

SNCA rs11931074 polymorphism correlates with spontaneous brain activity and motor symptoms in Chinese patients with Parkinson’s disease

Authors: Qian-Qian Si, Yong-Sheng Yuan, Yan Zhi, Min Wang, Jian-Wei Wang, Yu-Ting Shen, Li-Na Wang, Jun-Yi Li, Xi-Xi Wang, Ke-Zhong Zhang

Published in: Journal of Neural Transmission | Issue 8/2019

Abstract

The α-synuclein (SNCA) gene is thought to be involved in levels of α-synuclein and influence the susceptibility for the development of Parkinson’s disease (PD). The aim of the present study is to explore the association among SNCA rs1193074 polymorphism, spontaneous brain activity and clinical symptoms in PD patients. 62 PD patients and 47 healthy controls (HC) were recruited and underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans. Also blood sample of each participant was genotyped for rs11931074 polymorphism (PD: TT = 19, GT = 32, GG = 11; HC: TT = 10, GT = 25, GG = 12) and then examined to ascertain the influence of different genotypes on regional brain activity with amplitude low-frequency fluctuation analysis (ALFF). Furthermore, we evaluated the relationship among genotypes, interactive brain region and clinical symptoms in PD. Compared with HC subjects, PD patients showed decreased ALFF values in right lingual gyrus and increased ALFF values in right cerebellum posterior lobe. Significant interaction of ‘‘groups × genotypes’’ was found in the right angular gyrus, where there were higher ALFF values in TT genotype than in GT or GG genotype in the PD group and there was a contrary trend in the HC group. And further Spearman’s correlative analyses revealed that ALFF values in right angular gyrus were negatively associated with unified Parkinson’s disease rating scale (UPDRS) III score in PD-TT genotype. Our study shows for the first time that SNCA rs11931074 polymorphism might modulate brain functional alterations and correlate with motor symptoms in Chinese PD patients.

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Title: SNCA rs11931074 polymorphism correlates with spontaneous brain activity and motor symptoms in Chinese patients with Parkinson’s disease
Authors: Qian-Qian Si
Yong-Sheng Yuan
Yan Zhi
Min Wang
Jian-Wei Wang
Yu-Ting Shen
Li-Na Wang
Jun-Yi Li
Xi-Xi Wang
Ke-Zhong Zhang
Publication date: 01-08-2019
Publisher: Springer Vienna
Keyword: Parkinson's Disease
Published in: Journal of Neural Transmission / Issue 8/2019
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-019-02038-4

At a glance: The STEP trials

Springer Medicine

SNCA rs11931074 polymorphism correlates with spontaneous brain activity and motor symptoms in Chinese patients with Parkinson’s disease

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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