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01-05-2020 | Parkinson's Disease | Original Communication

Nonmotor symptoms of 820 Taiwanese patients with Parkinson’s disease: an exploratory-comparative study

Authors: Yi-Chieh Chen, Ying-Zu Huang, Yi-Hsin Weng, Chiung-Chu Chen, June Hung, Yi-Ying Lin, Wey-Yil Lin, Rou‐Shayn Chen

Published in: Journal of Neurology | Issue 5/2020

Abstract

Introduction

Nonmotor symptoms (NMSs) severely affect the daily quality of life of patients with Parkinson’s disease (PD). Although many studies have documented the clinical characteristics of NMSs in PD patients, some issues remain unaddressed. The severity and gender distribution of NMSs in Asian and the Western patients differ. The correlations between clinical characteristics and NMS manifestations remain unclear. We studied these relationships in a large cohort of Taiwanese PD patients.

Methods

Patients with PD were recruited from the outpatient clinic of a tertiary medical center and evaluated with standardized assessment protocols, including the NonMotor Symptoms Scale (NMSS), Unified Parkinson’s Disease Rating Scale (UPDRS), Hoehn and Yahr (H&Y) scale, Mini-Mental Status Examination, and Montreal Cognitive Assessment.

Results

Among 820 patients enrolled, 41.8% were female. The prevalence of the NMSs was 96.5%, with attention/memory (79.51%) being the most frequently involved domain. The mean severity score on the NMSS was 36.48 ± 34.30. Male patients reported higher NMS prevalence and severity than female patients, mostly in the gastrointestinal tract and urinary domains. We found that the severity of NMSs was correlated with disease duration, UPDRS Part III score, and H&Y stage.

Conclusion

Although they exhibited similar NMS prevalence, Taiwanese PD patients reported less intense NMSs compared with those reported by Western patients. Furthermore, the NMS items our patients emphasized and gender discrepancies were distinct from those in Western studies.

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Title: Nonmotor symptoms of 820 Taiwanese patients with Parkinson’s disease: an exploratory-comparative study
Authors: Yi-Chieh Chen
Ying-Zu Huang
Yi-Hsin Weng
Chiung-Chu Chen
June Hung
Yi-Ying Lin
Wey-Yil Lin
Rou‐Shayn Chen
Publication date: 01-05-2020
Publisher: Springer Berlin Heidelberg
Keyword: Parkinson's Disease
Published in: Journal of Neurology / Issue 5/2020
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-020-09708-4

At a glance: The STEP trials

Springer Medicine

Nonmotor symptoms of 820 Taiwanese patients with Parkinson’s disease: an exploratory-comparative study

Abstract

Introduction

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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