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Open Access 01-12-2024 | Parkinson's Disease | Research

Gender gap in deep brain stimulation for Parkinson’s disease: preliminary results of a retrospective study

Authors: Teresa Somma, Ilaria Bove, Francesca Vitulli, Domenico Solari, Andrea Bocchino, Carmela Palmiero, Maria Rosaria Scala, Cesare Zoia, Paolo Cappabianca, Felice Esposito

Published in: Neurosurgical Review | Issue 1/2024

Abstract

Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment of PD for both women and men. However, discussions have been reported about the impact of STN-DBS surgery in PD. The aim of our study is to identify differences between men and women in terms of pre- and post-DBS symptoms and try to explain the possible causes. In the current study, we evaluated the gender impact on STN-DBS in PD at the Department of Neurosurgery of University of Naples “Federico II” from 2013 to 2021. Motor and non-motor symptoms were evaluated. To compare the data before and after surgery and between the genders, Wilcoxon-Mann–Whitney tests were performed. A total of 43 patients with PD were included; of them, 17 (39%) were female. Baseline evaluation revealed no gender differences in the age of onset (p = 0.87). Not significant differences were noted in the Unified Parkinson’s Disease Rating Scale (UPDRS) pre-surgery score, but if we consider UPDRS subscores of motor examination, significant clinical improvement was reported in both male and female in terms of UPDRS pre- and post-surgery (p < 0.001). STN-DBS is a highly effective treatment for motor and non-motor symptoms of PD for both women and men but our study hints towards gender-specific outcomes in motor domains. Improving our knowledge in this field can allow us to implement strategies to identify new directions in the development of an adequate treatment of PD in terms of surgical intervention and in consideration of the gender.

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Title: Gender gap in deep brain stimulation for Parkinson’s disease: preliminary results of a retrospective study
Authors: Teresa Somma
Ilaria Bove
Francesca Vitulli
Domenico Solari
Andrea Bocchino
Carmela Palmiero
Maria Rosaria Scala
Cesare Zoia
Paolo Cappabianca
Felice Esposito
Publication date: 01-12-2024
Publisher: Springer Berlin Heidelberg
Keywords: Parkinson's Disease
Deep Brain Stimulation
Published in: Neurosurgical Review / Issue 1/2024
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI: https://doi.org/10.1007/s10143-024-02290-7

2024 ASCO Annual Meeting

Springer Medicine

Gender gap in deep brain stimulation for Parkinson’s disease: preliminary results of a retrospective study

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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