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Neurological Sciences

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01-02-2020 | Parkinson's Disease | Review Article

Association between alpha-synuclein (SNCA) rs11931074 variability and susceptibility to Parkinson’s disease: an updated meta-analysis of 41,811 patients

Authors: Bingying Du, Qiang Xue, Caiquan Liang, Cunxiu Fan, Meng Liang, Yanbo Zhang, Xiaoying Bi, Lijun Hou

Published in: Neurological Sciences | Issue 2/2020

Abstract

Background and objectives

Parkinson’s disease (PD) is one of the most common forms of neurodegenerative disorders, and its etiology remains unclear. Single nucleotide polymorphisms (SNPs) of alpha-synuclein (SNCA) have been found to be significantly associated with PD risk. In particular, the variant rs11931074 was found in one meta-analysis to appear to play a role in the occurrence of PD. This finding has been questioned in subsequent studies, however. The aim of this study was to determine the relationship between PD risk and rs11931074 polymorphism.

Methods

We performed a systematic online search, including PubMed, Web of Science, EMBASE, Cochrane Library, and CNKI (China National Knowledge Infrastructure), aiming to identify case–control studies looking at the role of rs11931074 in PD. We performed calculations of pooled odds ratio (OR) and 95% confidence interval (95% CI) to assess the associations, and subgroup meta-analyses to verify differences between various ethnicities of different study populations.

Results

A total of 13 studies involving 13,403 cases and 28,408 controls met the inclusion criteria after assessment by two reviewers. Overall, there exists significant associations between SNCA rs11931074 polymorphism and the risk of PD under five genetic models (allele contrast model: T vs. G, OR = 1.28, 95% CI = 1.12–1.45, P = 0.0001; homozygote model: TG vs. GG, OR = 1.55, 95% CI = 1.17–2.05, P = 0.002; heterozygote model (TT vs. GG, OR = 1.23, 95% CI = 1.05–1.42, P = 0.009; dominant model: TG+TT vs. GG: OR = 1.25, 95% CI = 1.05–1.50, P = 0.01 and recessive model: TT vs. TG+GG: OR = 1.40, 95% CI = 1.18–1.68, P = 0.0002). When ethnicities were stratified, significant associations were found in the allelic, homozygote, and recessive models for Asians, and in the allelic model for Caucasians.

Conclusion

SNCA rs11931074 polymorphism is found to be associated with PD risk and this risk appears to be influenced by genetic status and ethnicity.

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Title: Association between alpha-synuclein (SNCA) rs11931074 variability and susceptibility to Parkinson’s disease: an updated meta-analysis of 41,811 patients
Authors: Bingying Du
Qiang Xue
Caiquan Liang
Cunxiu Fan
Meng Liang
Yanbo Zhang
Xiaoying Bi
Lijun Hou
Publication date: 01-02-2020
Publisher: Springer International Publishing
Keyword: Parkinson's Disease
Published in: Neurological Sciences / Issue 2/2020
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-019-04107-8

At a glance: The STEP trials

Springer Medicine

Association between alpha-synuclein (SNCA) rs11931074 variability and susceptibility to Parkinson’s disease: an updated meta-analysis of 41,811 patients

Abstract

Background and objectives

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background and objectives

Methods

Results

Conclusion

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