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Neuroscience Bulletin

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01-04-2019 | Letter to the Editor

Parkinson’s Disease Risk Variant rs1109303 Regulates the Expression of INPP5K and CRK in Human Brain

Authors: Guiyou Liu, Yi Zhao, Jing-yi Sun, Bao-liang Sun

Published in: Neuroscience Bulletin | Issue 2/2019

Excerpt

Dear Editor, …

Lou F, Li M, Ren Y, Luo XG, Liu N, Li X. CLOCK rs1801260 polymorphism is associated with susceptibility to Parkinson’s disease in a Chinese population. Neurosci Bull 2017, 33: 734–736.CrossRefPubMedPubMedCentral

Yuan L, Song Z, Deng X, Yang Z, Yang Y, Guo Y, et al. Genetic analysis of FBXO2, FBXO6, FBXO12, and FBXO41 variants in Han Chinese patients with sporadic Parkinson’s disease. Neurosci Bull 2017, 33: 510–514.CrossRefPubMedPubMedCentral

Liu G, Bao X, Jiang Y, Liao M, Jiang Q, Feng R, et al. Identifying the association between Alzheimer’s disease and Parkinson’s disease using genome-wide association studies and protein-protein interaction network. Mol Neurobiol 2015, 52: 1629–1636.CrossRefPubMed

Liu G, Bao X, Wang R. Expression quantitative trait loci regulate HNF4A and PTBP1 expression in human brains. Proc Natl Acad Sci U S A 2015, 112: E3975.CrossRefPubMedPubMedCentral

Liu G, Liu Y, Jiang Q, Jiang Y, Feng R, Zhang L, et al. Convergent genetic and expression datasets highlight TREM2 in Parkinson’s disease susceptibility. Mol Neurobiol 2016, 53: 4931–4938.CrossRefPubMed

Nazeri A, Roostaei T, Sadaghiani S, Chakravarty MM, Eberly S, Lang AE, et al. Genome-wide variant by serum urate interaction in Parkinson’s disease. Ann Neurol 2015, 78: 731–741.CrossRefPubMed

Liu G, Xu Y, Jiang Y, Zhang L, Feng R, Jiang Q. PICALM rs3851179 variant confers susceptibility to Alzheimer’s disease in Chinese population. Mol Neurobiol 2017, 54: 3131–3136.CrossRefPubMed

Liu G, Hu Y, Jin S, Jiang Q. Genetic variant rs763361 regulates multiple sclerosis CD226 gene expression. Proc Natl Acad Sci U S A 2017, 114: E906–E907.CrossRefPubMedPubMedCentral

Liu G, Zhang F, Jiang Y, Hu Y, Gong Z, Liu S, et al. Integrating genome-wide association studies and gene expression data highlights dysregulated multiple sclerosis risk pathways. Mult Scler 2017, 23: 205–212.CrossRefPubMed

10.

Ramasamy A, Trabzuni D, Guelfi S, Varghese V, Smith C, Walker R, et al. Genetic variability in the regulation of gene expression in ten regions of the human brain. Nat Neurosci 2014, 17: 1418–1428.CrossRefPubMedPubMedCentral

11.

Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science 2015, 348: 648–660.

12.

Westra HJ, Peters MJ, Esko T, Yaghootkar H, Schurmann C, Kettunen J, et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat Genet 2013, 45: 1238–1243.CrossRefPubMedPubMedCentral

13.

Zhernakova DV, Deelen P, Vermaat M, van Iterson M, van Galen M, Arindrarto W, et al. Identification of context-dependent expression quantitative trait loci in whole blood. Nat Genet 2017, 49: 139–145.CrossRefPubMed

14.

Joehanes R, Zhang X, Huan T, Yao C, Ying SX, Nguyen QT, et al. Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies. Genome Biol 2017, 18: 16.CrossRefPubMedPubMedCentral

15.

Blazejewski SM, Bennison SA, Smith TH, Toyo-Oka K. Neurodevelopmental genetic diseases associated with microdeletions and microduplications of chromosome 17p13.3. Front Genet 2018, 9: 80.

Title: Parkinson’s Disease Risk Variant rs1109303 Regulates the Expression of INPP5K and CRK in Human Brain
Authors: Guiyou Liu
Yi Zhao
Jing-yi Sun
Bao-liang Sun
Publication date: 01-04-2019
Publisher: Springer Singapore
Published in: Neuroscience Bulletin / Issue 2/2019
Print ISSN: 1673-7067
Electronic ISSN: 1995-8218
DOI: https://doi.org/10.1007/s12264-018-0289-4

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Parkinson’s Disease Risk Variant rs1109303 Regulates the Expression of INPP5K and CRK in Human Brain

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Keynote webinar | Spotlight on medication adherence

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