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Open Access 01-04-2020 | Original Article

Parenthood and risk of hip fracture: a 10-year follow-up prospective study of middle-aged women and men in China

Authors: K. Peng, P. Yao, L. Yang, C. Kartsonaki, D. Bennett, M. Tian, Y. Guo, Z. Bian, Y. Chen, Z. Chen, M. Woodward, R. Ivers, R. Clarke

Published in: Osteoporosis International | Issue 4/2020

Abstract

Summary

This prospective study of Chinese adults demonstrated an inverse J-shaped association of number of children with risk of hip fracture in both men and postmenopausal women aged 50 years or older. Women with 2 or 3 children and men with 4 children had the lowest risk of hip fracture.

Introduction

Women have higher absolute risks of fracture than men, which is believed to reflect differences in oestrogen exposure. The aim of this study was to compare the associations of number of children with risk of hip fracture between men and women aged over 50 years.

Methods

The China Kadoorie Biobank (CKB) recruited 133,399 women and 110,296 men, aged 50 years or older between 2004 and 2008. During 10-year follow-up, 2068 participants (1394 women and 674 men) suffered a hip fracture. Cox regression analysis was used to estimate sex-specific adjusted hazard ratios (HRs) and 95% CI for incident hip fracture.

Results

Over 98% of both subsets of men and women aged 50 or older reported having children. Women who had 2 or 3 children had the lowest risks of hip fracture compared with other groups. Compared with nulliparous women, the adjusted HR for hip fracture were 0.89 (95% CI; 0.72, 1.10) for 1 child, 0.79 (0.70, 0.90) for 2 children, 0.79 (0.72, 0.87) for 3 children, 0.81 (0.72, 0.91) for 4 children, and 0.95 (0.83, 1.10) for those with 5 or more children. The associations of number of children with hip fracture were broadly consistent in men of a similar age.

Conclusions

The concordant effects of the number of children with risk of hip fracture between men and women suggest that the lower risks in multiparous women are not due to differences in oestrogen exposure or other biological effects, but may reflect residual confounding by socioeconomic or lifestyle factors.

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Title: Parenthood and risk of hip fracture: a 10-year follow-up prospective study of middle-aged women and men in China
Authors: K. Peng
P. Yao
L. Yang
C. Kartsonaki
D. Bennett
M. Tian
Y. Guo
Z. Bian
Y. Chen
Z. Chen
M. Woodward
R. Ivers
R. Clarke
Publication date: 01-04-2020
Publisher: Springer London
Published in: Osteoporosis International / Issue 4/2020
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-019-05185-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Parenthood and risk of hip fracture: a 10-year follow-up prospective study of middle-aged women and men in China

Abstract

Summary

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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