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Pediatric Drugs
Published in: Pediatric Drugs 6/2004

01-11-2004 | Original Research Article

Parent-Reported Outcomes for Treatment of Acute Otitis Media with Cefdinir or Amoxicillin/Clavulanate Oral Suspensions

Authors: Dr Mary A. Cifaldi, Maria M. Paris, Karen J. Devcich, Stanley Bukofzer

Published in: Pediatric Drugs | Issue 6/2004

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Abstract

Objective: To compare parent-reported outcomes (satisfaction, tolerability, compliance, and work/daycare missed) for children (aged 6 months to 6 years) receiving either cefdinir or amoxicillin/clavulanate for acute otitis media.
Method: In a phase IV, investigator-blinded, parallel-group, randomized, multicenter study, parents or legal guardians were asked to complete the Otitis Parent Questionnaire (OPQ) 12–14 days after the first dose of cefdinir or amoxicillin/clavulanate oral suspensions. Responses in each of the outcome domains were analyzed using non-parametric statistical analysis.
Results: Of 367 parents/guardians who completed the questionnaire, better ease of use (p = 0.009) and taste (p < 0.0001) were associated with cefdinir versus amoxicillin/clavulanate treatment, and children were significantly more likely to experience vomiting with amoxicillin/clavulanate (16% vs 8%; p = 0.016). Parents also reported that their children were much more likely to take all of their medication if receiving cefdinir (68% vs 53% for amoxicillin/clavulanate; p = 0.005). There were no statistically significant differences between groups in work/daycare missed.
Conclusion: Based on parents’ assessment using the OPQ, cefdinir was easier to administer and tasted better than amoxicillin/clavulanate. Children who received cefdinir also experienced less vomiting and had greater compliance than children who received amoxicillin/clavulanate.
Footnotes
1
The use of trade names is for product identification purposes only and does not imply endorsement.
 
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Metadata
Title
Parent-Reported Outcomes for Treatment of Acute Otitis Media with Cefdinir or Amoxicillin/Clavulanate Oral Suspensions
Authors
Dr Mary A. Cifaldi
Maria M. Paris
Karen J. Devcich
Stanley Bukofzer
Publication date
01-11-2004
Publisher
Springer International Publishing
Published in
Pediatric Drugs / Issue 6/2004
Print ISSN: 1174-5878
Electronic ISSN: 1179-2019
DOI
https://doi.org/10.2165/00148581-200406060-00006

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