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BMC Ophthalmology

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Open Access 01-12-2014 | Case report

Paraneoplastic neuromyelitis optica associated with ANNA-1 antibodies in invasive thymoma

Authors: Hee Kyung Yang, Se Joon Woo, Woong-Yang Park, Jeong-Min Hwang

Published in: BMC Ophthalmology | Issue 1/2014

Abstract

Background

Thymoma is associated with various paraneoplastic autoimmune disorders. Herein, we report paraneoplastic neuromyelitis optica (NMO) associated with both anti-aquaporin-4 (AQP4) immunoglobulin G (IgG) and type 1 antineuronal nuclear antibody (ANNA-1) in an invasive thymoma patient.

Case presentation

A woman presented with a sudden onset of bilateral progressive visual loss associated with recurrence of invasive thymoma, 6 years after thymectomy and immunosuppressive treatment. AQP4-IgG and ANNA-1 were present in the patient’s serum. Visual outcome was poor despite immunosuppressive treatment. Longitudinally extensive transverse myelitis developed 27 months after the onset of visual symptoms.

Conclusions

We have reported a case of paraneoplastic NMO associated with both AQP4-IgG and ANNA-1 autoantibodies in an invasive thymoma patient.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2415/14/106/prepub

Title: Paraneoplastic neuromyelitis optica associated with ANNA-1 antibodies in invasive thymoma
Authors: Hee Kyung Yang
Se Joon Woo
Woong-Yang Park
Jeong-Min Hwang
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: BMC Ophthalmology / Issue 1/2014
Electronic ISSN: 1471-2415
DOI: https://doi.org/10.1186/1471-2415-14-106

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Paraneoplastic neuromyelitis optica associated with ANNA-1 antibodies in invasive thymoma

Abstract

Background

Case presentation

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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