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Tumor Biology
Published in: Tumor Biology 1/2016

01-01-2016 | Original Article

PAQR3 plays a suppressive role in laryngeal squamous cell carcinoma

Authors: Qiang Wu, Kun Zhuang, Huijun Li

Published in: Tumor Biology | Issue 1/2016

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Abstract

Laryngeal squamous cell carcinoma (LSCC) is a common type of head and neck malignancy worldwide. The molecular mechanism of LSCC remains not well understood. PAQR3 (progestin and AdipoQ receptors) is a member of the progestin and adipoQ receptor (PAQR) family. Many studies have showed that PAQR3 acts as a new tumor suppressor. However, its expression and functions in LSCC are still unknown. In our study, the expression of PAQR3 was downregulated in human LSCC tissues compared to that in adjacent tissues. Moreover, overexpression of PAQR3 suppressed LSCC cell proliferation and invasion. In addition, PAQR3 inhibited cell proliferation and invasion by regulating ERK phosphorylation. In conclusion, our data demonstrated that PAQR3 acted a tumor suppressive role in LSCC, providing a novel diagnostic and therapeutic option for LSCC in the future.
Literature
1.
Tian L, Li M, Ge J, Guo Y, Sun Y, Liu M, et al. Mir-203 is downregulated in laryngeal squamous cell carcinoma and can suppress proliferation and induce apoptosis of tumours. Tumour Biol J Int Soc Oncodev Biol Med. 2014;35:5953–63.CrossRef
2.
Li W, Ma H, Sun J. Microrna34a/c function as tumor suppressors in hep2 laryngeal carcinoma cells and may reduce galnt7 expression. Mol Med Rep. 2014;9:1293–8.PubMed
3.
Xu Y, Wang K, Gao W, Zhang C, Huang F, Wen S, et al. Microrna-106b regulates the tumor suppressor runx3 in laryngeal carcinoma cells. FEBS Lett. 2013;587:3166–74.CrossRefPubMed
4.
Bian K, Fan J, Zhang X, Yang XW, Zhu HY, Wang L, et al. Microrna-203 leads to g1 phase cell cycle arrest in laryngeal carcinoma cells by directly targeting survivin. FEBS Lett. 2012;586:804–9.CrossRefPubMed
5.
Ren J, Zhu D, Liu M, Sun Y, Tian L. Downregulation of mir-21 modulates ras expression to promote apoptosis and suppress invasion of laryngeal squamous cell carcinoma. Eur J Cancer. 2010;46:3409–16.CrossRefPubMed
6.
Guo Y, Fu W, Chen H, Shang C, Zhong M. Mir-24 functions as a tumor suppressor in hep2 laryngeal carcinoma cells partly through down-regulation of the s100a8 protein. Oncol Rep. 2012;27:1097–103.PubMed
7.
Yu X, Wu Y, Liu Y, Deng H, Shen Z, Xiao B, et al. Mir-21, mir-106b and mir-375 as novel potential biomarkers for laryngeal squamous cell carcinoma. Curr Pharm Biotechnol. 2014;15:503–8.CrossRefPubMed
8.
Tian L, Zhang J, Ge J, Xiao H, Lu J, Fu S, et al. Microrna-205 suppresses proliferation and promotes apoptosis in laryngeal squamous cell carcinoma. Med Oncol. 2014;31:785.CrossRefPubMed
9.
Wang L, Wang X, Li Z, Xia T, Zhu L, Liu B, et al. Paqr3 has modulatory roles in obesity, energy metabolism, and leptin signaling. Endocrinology. 2013;154:4525–35.CrossRefPubMed
10.
Wu HG, Zhang WJ, Ding Q, Peng G, Zou ZW, Liu T, et al. Identification of paqr3 as a new candidate tumor suppressor in hepatocellular carcinoma. Oncol Rep. 2014;32:2687–95.PubMed
11.
Fan F, Feng L, He J, Wang X, Jiang X, Zhang Y, et al. Rktg sequesters b-raf to the golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells. Carcinogenesis. 2008;29:1157–63.CrossRefPubMed
12.
Garitaonandia I, Smith JL, Kupchak BR, Lyons TJ. Adiponectin identified as an agonist for paqr3/rktg using a yeast-based assay system. J Recept Signal Transduct Res. 2009;29:67–73.CrossRefPubMedPubMedCentral
13.
Zhang Y, Jiang X, Qin X, Ye D, Yi Z, Liu M, et al. Rktg inhibits angiogenesis by suppressing mapk-mediated autocrine vegf signaling and is downregulated in clear-cell renal cell carcinoma. Oncogene. 2010;29:5404–15.CrossRefPubMed
14.
Ling ZQ, Guo W, Lu XX, Zhu X, Hong LL, Wang Z, et al. A golgi-specific protein paqr3 is closely associated with the progression, metastasis and prognosis of human gastric cancers. Ann Oncol Off J Eur Soc Med Oncol. 2014;25:1363–72.CrossRef
15.
Ma Z, Wang Y, Piao T, Li Z, Zhang H, Liu Z, Liu J. The tumor suppressor role of paqr3 in osteosarcoma. Tumour Biol J Int Soc Oncodev Biol Med. 2014.
16.
Yu L, Zhou L, Cheng Y, Sun L, Fan J, Liang J, et al. Microrna-543 acts as an oncogene by targeting paqr3 in hepatocellular carcinoma. Am J Cancer Res. 2014;4:897–906.PubMedPubMedCentral
17.
Wang X, Li X, Fan F, Jiao S, Wang L, Zhu L, et al. Paqr3 plays a suppressive role in the tumorigenesis of colorectal cancers. Carcinogenesis. 2012;33:2228–35.CrossRefPubMed
18.
Xiu Y, Liu Z, Xia S, Jin C, Yin H, Zhao W, et al. Microrna-137 upregulation increases bladder cancer cell proliferation and invasion by targeting paqr3. PLoS One. 2014;9:e109734.CrossRefPubMedPubMedCentral
19.
Yue X, Wang P, Xu J, Zhu Y, Sun G, Pang Q, et al. Microrna-205 functions as a tumor suppressor in human glioblastoma cells by targeting vegf-a. Oncol Rep. 2012;27:1200–6.PubMed
20.
Li Z, Lei H, Luo M, Wang Y, Dong L, Ma Y, et al. DNA methylation downregulated mir-10b acts as a tumor suppressor in gastric cancer. Gastric Cancer Off J Int Gastric Cancer Assoc Jpn Gastric Cancer Assoc. 2015;18:43–54.
21.
Li Z, Yu X, Wang Y, Shen J, Wu WK, Liang J, Feng F. By downregulating tiam1 expression, microrna-329 suppresses gastric cancer invasion and growth. Oncotarget. 2014.
Metadata
Title
PAQR3 plays a suppressive role in laryngeal squamous cell carcinoma
Authors
Qiang Wu
Kun Zhuang
Huijun Li
Publication date
01-01-2016
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 1/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-3770-y

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