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Skeletal Radiology
Published in: Skeletal Radiology 6/2021

01-06-2021 | Panniculitis | Case Report

BRAF inhibitor-induced panniculitis in patients treated for stage IV metastatic melanoma: a case series

Authors: David J. Bartlett, Andrew J. Erie, Francis I. Baffour, Stephen M. Broski, Katrina N. Glazebrook

Published in: Skeletal Radiology | Issue 6/2021

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Abstract

BRAF and MEK inhibitor combination therapy is the standard treatment for patients with BRAF V600E mutant metastatic melanoma. Neutrophilic panniculitis is a known rare complication of BRAF inhibitor therapy and can act as a potential mimic of melanoma metastases on 18F-FDG PET/CT. In this case series, we present three cases of BRAF inhibitor-induced panniculitis in patients being treated for BRAF-mutant metastatic melanoma and emphasize the use of ultrasound to differentiate between panniculitis lesions, which are typically ill-defined echogenic masses and subcutaneous soft tissue melanoma metastases, which present as hypoechoic vascular masses.
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Metadata
Title
BRAF inhibitor-induced panniculitis in patients treated for stage IV metastatic melanoma: a case series
Authors
David J. Bartlett
Andrew J. Erie
Francis I. Baffour
Stephen M. Broski
Katrina N. Glazebrook
Publication date
01-06-2021
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 6/2021
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-020-03665-9

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