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Immunologic Research
Published in: Immunologic Research 1/2017

01-02-2017 | Environment and Autoimmunity

Pancreatitis after human papillomavirus vaccination: a matter of molecular mimicry

Authors: Mojca Bizjak, Or Bruck, Sonja Praprotnik, Shani Dahan, Yehuda Shoenfeld

Published in: Immunologic Research | Issue 1/2017

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Abstract

A 20-year-old man developed severe abdominal pain 1 week after being vaccinated with the first dose of quadrivalent human papillomavirus (HPV) vaccine (Gardasil®). Despite ongoing symptoms of nausea and pain, he received the second dose of the vaccine. Only 10 days later, laboratory results revealed significantly elevated pancreatic enzymes, and with concomitant abdominal pain and vomiting, he was diagnosed with acute pancreatitis. This case of acute pancreatitis after HPV vaccination is not a novel entity. Although confirming the relationship between pancreatitis and vaccine is challenging, some factors suggest a possible link, including the positive re-challenge upon repeated exposure to the vaccine, HPV vaccine as probable causal relationship to other autoimmune diseases and a probable mechanism of molecular mimicry. In conjunction with aluminum adjuvant, the induction of immunity through molecular mimicry may potentially culminate in production of cytotoxic autoantibodies with a particular affinity for pancreatic acinar cells.
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Metadata
Title
Pancreatitis after human papillomavirus vaccination: a matter of molecular mimicry
Authors
Mojca Bizjak
Or Bruck
Sonja Praprotnik
Shani Dahan
Yehuda Shoenfeld
Publication date
01-02-2017
Publisher
Springer US
Published in
Immunologic Research / Issue 1/2017
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-016-8823-9

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