Pancreatic Metastasis From Musculoskeletal Sarcoma: A Case Report With Malignant Fibrous Histiocytoma and Review of the Literature

Excerpt

Estimates of the frequency of pancreatic metastases vary widely. At autopsy, the pancreas has been found to be a site of metastasis in 3–12% of patients with malignant tumors [1‐3]. However, the occurrence of resectable metastasis to the pancreas is less frequent because many patients already have widespread disease at the time of diagnosis of pancreatic metastasis. Only 0.5–3.0% of patients who have undergone pancreatic resection demonstrated metastatic disease [4‐6]. Surgical management of pancreatic metastasis is poorly defined because in the past the operative risks of pancreatic surgery were too high to justify [7]. Recent improvements in morbidity and mortality after pancreatic resection allow for radical surgery with curative intent [4‐6]. Primary tumors that give rise most frequently to metastases to the pancreas include renal cell carcinoma, colorectal, breast, and lung cancers; pancreatic metastasis from sarcomas is extremely rare. Herein we report a case of very rare synchronous solitary metastasis to the pancreas from malignant fibrous histiocytoma (MFH, a most common type of soft-tissue sarcoma) [8, 9]. Moreover, we review the literature to discuss the appropriate management of pancreatic metastasis from musculoskeletal sarcomas [10‐16]. …