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BMC Psychiatry
Published in: BMC Psychiatry 1/2011

Open Access 01-12-2011 | Research article

P300 amplitude is insensitive to working memory load in schizophrenia

Authors: Pablo A Gaspar, Sergio Ruiz, Francisco Zamorano, Marcela Altayó, Carolina Pérez, Conrado A Bosman, Francisco Aboitiz

Published in: BMC Psychiatry | Issue 1/2011

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Abstract

Background

Working memory (WM) tasks usually elicit a P300 ERP component, whose amplitude decreases with increasing WM load. So far, this effect has not been studied in schizophrenics (SZs), a group that is considered to have an aberrant brain connectivity and impairments in WM capacity. The aim of this study was to determine the dependency of the P300 component on WM load in a sample of SZ subjects.

Methods

We recorded 26 subjects (13 SZ patients and their matched controls) with an 80-channel electroencephalogram. Subjects performed an N-back task, a WM paradigm that manipulates the number of items to be stored in memory.

Results

In healthy subjects, P300 amplitude was highest in the low WM load condition, and lowest in both the attentional control condition and the high WM load condition. In contrast, SZs evidenced low P300 amplitude in all conditions. A significant between group difference in P300 amplitude was evidenced only at the low WM load condition (1 -back), being smaller in SZs.

Conclusions

SZ subjects display a lower than normal P300 amplitude, which does not vary as a function of memory load. These results are consistent with a general impairment in WM capacity in these patients.
Appendix
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Metadata
Title
P300 amplitude is insensitive to working memory load in schizophrenia
Authors
Pablo A Gaspar
Sergio Ruiz
Francisco Zamorano
Marcela Altayó
Carolina Pérez
Conrado A Bosman
Francisco Aboitiz
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2011
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/1471-244X-11-29

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