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Journal of Neuroinflammation

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Open Access 01-12-2010 | Research

P2X7 receptor regulates leukocyte infiltrations in rat frontoparietal cortex following status epilepticus

Authors: Ji-Eun Kim, Hea Jin Ryu, Seong-Il Yeo, Tae-Cheon Kang

Published in: Journal of Neuroinflammation | Issue 1/2010

Abstract

Background

In the present study, we investigated the roles of P2X7 receptor in recruitment and infiltration of neutrophil during epileptogenesis in rat epilepsy models.

Methods

Status epilepticus (SE) was induced by pilocarpine in rats that were intracerebroventricularly infused with either saline, 2',3'-O-(4-benzoylbenzoyl)-adenosine 5'-triphosphate (BzATP), adenosine 5'-triphosphate-2',3'-dialdehyde (OxATP), or IL-1Ra (interleukin 1 receptor antagonist) prior to SE induction. Thereafter, we performed immunohistochemical studies for myeloperoxidase (MPO), CD68, interleukin-1β (IL-1β), monocyte chemotactic protein-1 (MCP-1) and macrophage inflammatory protein-2 (MIP-2).

Results

In saline-infused animals, neutrophils and monocytes were observed in frontoparietal cortex (FPC) at 1 day and 2 days after SE, respectively. In BzATP-infused animals, infiltrations of neutrophils and monocytes into the FPC were detected at 12 hr and 1 day after SE, respectively. In OxATP-infused animals, neutrophils and monocytes infiltrated into the FPC at 1 day and 2 days after SE, respectively. However, the numbers of both classes of leukocytes were significantly lower than those observed in the saline-infused group. In piriform cortex (PC), massive leukocyte infiltration was detected in layers III/IV of saline-infused animals at 1-4 days after induction of SE. BzATP or OxATP infusion did not affect neutrophil infiltration in the PC. In addition, P2X7 receptor-mediated MCP-1 (released from microglia)/MIP-2 (released from astrocytes) regulation was related to SE-induced leukocyte infiltration in an IL-1β-independent manner.

Conclusions

Our findings suggest that selective regulation of P2X7 receptor-mediated neutrophil infiltration may provide new therapeutic approaches to SE or epilepsy.

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Title: P2X7 receptor regulates leukocyte infiltrations in rat frontoparietal cortex following status epilepticus
Authors: Ji-Eun Kim
Hea Jin Ryu
Seong-Il Yeo
Tae-Cheon Kang
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: Journal of Neuroinflammation / Issue 1/2010
Electronic ISSN: 1742-2094
DOI: https://doi.org/10.1186/1742-2094-7-65

At a glance: The STEP trials

Springer Medicine

P2X7 receptor regulates leukocyte infiltrations in rat frontoparietal cortex following status epilepticus

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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