Published in:
Open Access
01-11-2013 | Meeting abstract
P01-021 – Macrophage migration inhibitory factory in FMF
Authors:
I Sari, Y Savran, DL Kozaci, N Gunay, F Onen, S Akar
Published in:
Pediatric Rheumatology
|
Special Issue 1/2013
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Excerpt
Familial Mediterranean Fever (FMF) is an autoinflammatory disorder characterized by recurrent, inflammatory, self-limited episodes of fever and serositis. Neutrophils are one of the key players in the pathophysiology of FMF. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine involved in several inflammatory processes including innate and adaptive immune responses . In addition, MIF has been shown to regulate trafficking of inflammatory cells includingneutrophis to the sites of inflammation. Because its association with innate immunity, leukocyte trafficking, and inflammation MIF may be considered as an attractive cytokine in the pathogenesis of FMF. …
