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01-10-2010 | Original Article

Oxygen uptake kinetics during exercise in adults with Down syndrome

Authors: Goncalo V. Mendonca, Fernando D. Pereira, Bo Fernhall

Published in: European Journal of Applied Physiology | Issue 3/2010

Abstract

Persons with Down syndrome (DS) have diminished submaximal and peak work capacity. This study evaluated the dynamic response of oxygen uptake at onset and recovery (VO₂ kinetics) of constant-load exercise (moderate intensity 45% VO_2peak) in adults with DS. A total of 27 healthy participants aged 18–50 years performed graded treadmill exercise to assess peak VO₂: 14 with DS (9 males and 5 females) and 13 controls without disabilities (9 males and 4 females). Subjects also performed constant-load exercise tests at 45% VO_2peak to determine VO₂ on-transient and VO₂ off-transient responses. Peak VO₂ was lower in participants with DS as compared to controls (DS 30.2 ± 7.1; controls 46.1 ± 9.6 mL kg⁻¹ min⁻¹, P < 0.05). In contrast, at 45% VO_2peak, the time constants for the VO₂ on-transients (DS 34.6 ± 9.1; controls 37.6 ± 9.0 s) and VO₂ off-transients (DS 36.5 ± 12.3; controls 37.7 ± 7.0 s) were not significantly different between the groups. Additionally, there were no differences between on-transient and off-transient time constants in participants with DS or controls. These data demonstrate that the VO₂ kinetics at onset and recovery of moderate intensity exercise is similar between adults with DS and controls. Therefore, the submaximal exercise performance of these individuals is not affected by slowed VO₂ kinetics.

Agiovlasitis S, McCubbin J, Yun J, Pavol M, Widrick J (2009) Economy and preferred speed of walking in adults with and without Down syndrome. Adapt Phys Activ Q 26:118–130PubMed

Androne A, Hryniewicz K, Goldsmith R, Arwady A, Katz S (2003) Acetylcholinesterase inhibition with pyridostigmine improves heart rate recovery after maximal exercise in patients with chronic heart failure. Heart 89:854–858CrossRefPubMed

Bambrick L, Fiskum G (2008) Mitochondrial dysfunction in mouse trisomy 16 brain. Brain Res 1188:9–16CrossRefPubMed

Barstow T, Molé P (1987) Simulation of pulmonary O₂ uptake during exercise transients in humans. J Appl Physiol 63:2253–2261PubMed

Barstow T, Buchthal S, Zanconato S, Cooper M (1994) Muscle energetics and pulmonary oxygen uptake kinetics during moderate exercise. J Appl Physiol 77:1742–1749PubMed

Barstow T, Jones A, Nguyan P, Casaburi R (1996) Influence of muscle fiber type and pedal frequency on oxygen uptake kinetics of heavy exercise. J Appl Physiol 81:1642–1650PubMed

Bauer T, Regensteiner J, Brass E, Hiatt W (1999) Oxygen uptake kinetics are slowed in patients with peripheral arterial disease. J Appl Physiol 87:809–816PubMed

Beaver W, Wasserman K, Whipp B (1986) A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 60:2020–2027PubMed

Brown G (1992) Control of respiration and ATP synthesis in mammalian mitochondria cells. Biochem J 284:1–13PubMed

Burnley M, Doust J, Jones A (2006) Time required for the restoration of normal heavy exercise VO₂ kinetics following prior heavy exercise. J Appl Physiol 101:1320–1327CrossRefPubMed

Casaburi R, Storer T, Ben Dov I, Wasserman K (1987) Effect of endurance training on possible determinants of VO₂ during heavy exercise. J Appl Physiol 62:199–207PubMed

Cerretelli P, di Prampero PE (1987) Gas exchange in exercise. In: Farhi LE, Tenney SM (eds) Handbook of physiology. The respiratory system III, vol 4: Gas exchange. The American Physiological Society, Bethesda, pp 297–339

Demarle A, Slawinski J, Laffite L, Bocquet V, Koralsztein J, Billat V (2001) Decrease of O(2) deficit is a potential factor in increased time to exhaustion after specific endurance training. J Appl Physiol 90:947–953CrossRefPubMed

Denton R, McCormack J, Edgell N (1980) Role of calcium ions in the regulation of intramitochondrial metabolism. Biochem J 190:107–117PubMed

di Prampero P, Ferretti G (1990) Factors limiting maximal oxygen consumption in humans. Respir Physiol 80:113–127CrossRefPubMed

Donald P, Whipp B (1991) Asymmetries of oxygen uptake transients at the on- and offset of heavy exercise in humans. J Physiol 443:575–586

Eberhard Y, Eterradossi J, Rapacchi B (1989) Physical aptitudes to exertion in children with Down’s syndrome. J Ment Defic Res 33:167–174PubMed

Edwards AM, Challis NV, Chapman JH, Claxton DB, Fysh M (2005) The test-retest reliability of gas exchange kinetics in humans using a pseudo random binary sequence exercise test. Eur J Appl Physiol 85:333–338CrossRef

Engelen M, Porszaz J, Riley M, Wasserman K, Maehara K, Barstow T (1996) The effects of hypoxic hypoxia on O₂ uptake and heart rate kinetics during heavy exercise. J Appl Physiol 81:2500–2508PubMed

Fernhall B, Otterstetter M (2003) Attenuated responses to sympathoexcitation in individuals with Down syndrome. J Appl Physiol 94:2158–2165PubMed

Fernhall B, Millar A, Tymeson G, Burkett L (1990) Maximal exercise testing of mentally retarded adolescents and adults: reliability study. Arch Phys Med Rehabil 71:1065–1068PubMed

Fernhall B, Pitetti K, Rimmer J, McCubbin J, Rintala P, Millar A, Kittredge J, Burkett L (1996) Cardiorespiratory capacity of individuals with mental retardation including Down syndrome. Med Sci Sports Exerc 28:366–371CrossRefPubMed

Gladden L (1996) Lactate uptake by skeletal muscle. Exerc Sports Sci Rev 24:115–155

Grassi B (2000) Skeletal muscle VO₂ on-kinetics: set by O₂ delivery or by O₂ utilization? New insights into an old issue. Med Sci Sports Exerc 32:108–116CrossRefPubMed

Grassi B (2006) Oxygen uptake kinetics: why are they so slow? And what do they tell us? J Physiol Pharmacol 57:53–65PubMed

Guerra M, Llorens N, Fernhall B (2003) Chronotropic incompetence in individuals with Down syndrome. Arch Phys Med Rehabil 84:1604–1608CrossRefPubMed

Hochachka P, McClelland G (1997) Cellular metabolic homeostasis during large-scale change in ATP turnover rates in muscles. J Exp Biol 200:381–386PubMed

Hughson R, Kowalchuk J (1995) Kinetics of oxygen uptake for submaximal exercise in hyperoxia, normoxia, and hypoxia. Can J Appl Physiol 20:198–210PubMed

Kemps H, De Vries W, Hoogeveen A, Zonderland M, Thijssen E, Schep G (2007) Reproducibility of onset and recovery oxygen uptake kinetics in moderately impaired patients with chronic heart failure. Eur J Appl Physiol 100:45–52CrossRefPubMed

Kidling AE, Challis NV, Winter EM, Fysh M (2005) Characterization, asymmetry and reproducibility of on- and off-transient pulmonary oxygen uptake kinetics in endurance-trained runners. Eur J Appl Physiol 93:588–597CrossRef

Koike A, Yajima T, Adachi H, Shimizu N, Kano H, Sugimoto K, Niwa A, Marumo F, Hiroe M (1995) Evaluation of exercise capacity using submaximal exercise at constant work rate in patients with cardiovascular disease. Circulation 91:1719–1724PubMed

Lamarra N, Whipp B, Ward S, Wasserman K (1987) Effect of interbreath fluctuations on characterizing exercise gas exchange kinetics. J Appl Physiol 62:2003–2012CrossRefPubMed

McCreary C, Chilibeck P, Marsh G, Paterson D, Cunningham D, Tompson R (1996) Kinetics of pulmonary oxygen uptake and muscle phosphates during moderate intensity calf-exercise. J Appl Physiol 81:1331–1338PubMed

Mendonca G, Pereira F (2010) Heart rate recovery after exercise in adults with the Down syndrome. Am J Cardiol 105(10):1470–1473CrossRefPubMed

Mendonca G, Pereira F, Morato P, Fernhall B (2010) Walking economy of adults with Down syndrome. Int J Sports Med 31:10–15CrossRefPubMed

Murdoch J, Rodger J, Rao S, Fletcher C, Dunnigan M (1977) Down’s syndrome: an atheroma-free model? Br Med J 23:226–228CrossRef

Ozyener F, Rossiter HB, Ward S, Whipp B (2001) Influence of exercise intensity on the on- and off-transient kinetics of pulmonary oxygen uptake in humans. J Physiol (Lond) 533:891–902CrossRef

Pavia L, Myers J, Cesare R (1999) Recovery of oxygen uptake and heart rate in patients with coronary artery disease and heart failure. Chest 116:808–813CrossRefPubMed

Prince J, Jia S, Bave U, Annerén G, Oreland L (1994) Mitochondrial deficiencies in Down’s syndrome. J Neural Transm 8:171–181CrossRef

Puente-Maestu L, Sánz ML, Sánz JM, Ruiz de Oña JM, Rodríguez-Hermosa JL, Whipp BJ (2000) Effects of two types of training on pulmonary and cardiac responses to moderate exercise in patients with COPD. Eur Respir J 15:1026–1032CrossRefPubMed

Regensteiner JG, Bauer TA, Reusch JE, Brandenburg SL, Sippel JM, Vogelsong AM, Smith S, Wolfel EE, Eckel RH, Hiatt WR (1998) Abnormal oxygen uptake kinetic responses in women with type II diabetes mellitus. J Appl Physiol 85:310–317PubMed

Richards B, Enver F (1979) Blood pressure in Down’s syndrome. J Ment Defic Res 23:123–135PubMed

Rossiter H, Ward S, Kowalchuk J, Howe F, Griffiths J, Whipp B (2001) Effects of prior exercise on oxygen uptake and phosphocreatine kinetics during high-intensity knee extension exercise in humans. J Physiol 537:291–303CrossRefPubMed

Rossiter H, Ward S, Howe F, Wood D, Kowalchuk J, Griffiths J, Whipp B (2003) Effects of dichloroacetate on VO₂ and intramuscular 31P metabolite kinetics during high-intensity exercise in humans. J Appl Physiol 95:1105–1115PubMed

Schalcher C, Rickli H, Brehm M, Weilenmann D, Oechslin E, Kiowski W, Rocca H (2003) Prolonged oxygen uptake kinetics during low-intensity exercise are related to poor prognosis in patients with mid-to-moderate congestive heart failure. Chest 124:580–586CrossRefPubMed

Sietsema K (1992) Oxygen uptake kinetics in response to exercise in patients with pulmonary vascular disease. Am Rev Respir Dis 145:1052–1057PubMed

Tschakovsky M, Hughson R (1999) Interaction of factors determining oxygen uptake at the onset of exercise. J Appl Physiol 86:1101–1113PubMed

Wasserman K (1990) Overview and future directions. Circulation 81(Suppl 1):II59–II64PubMed

Wasserman K, Hansen J, Sue D, Whipp B (2005) Measurements during integrative cardiopulmonary exercise testing. In: Principles of exercise testing and interpretation—including pathophysiology and clinical applications, 4th edn. Lippincott Williams & Wilkins, Philadelphia, pp 76–110

Whipp B (1971) Rate constant for the kinetics of oxygen uptake during light exercise. J Appl Physiol 30:261–263PubMed

Whipp B, Mahler M (1980) Dynamics of pulmonary gas exchange during exercise. In: West J (ed) Pulmonary gas exchange: organism and environment. Academic Press, New York, pp 33–98

Whipp B, Ward S (1990) Physiological determinants of pulmonary gas exchange kinetics during exercise. Med Sci Sports Exerc 22:62–71PubMed

Whipp B, Wasserman K (1972) Oxygen uptake kinetics for various intensities of constant-load work. J Appl Physiol 33:351–356PubMed

Whipp B, Rossiter H, Ward S (2002) Exertional oxygen uptake kinetics: a stamen of stamina? Biochem Soc Trans 30:237–247CrossRefPubMed

Williamson J, Raven P, Whipp B (1996) Unaltered oxygen uptake kinetics at exercise onset with lower-body-positive pressure in humans. Exp Physiol 81:695–705PubMed

Title: Oxygen uptake kinetics during exercise in adults with Down syndrome
Authors: Goncalo V. Mendonca
Fernando D. Pereira
Bo Fernhall
Publication date: 01-10-2010
Publisher: Springer-Verlag
Published in: European Journal of Applied Physiology / Issue 3/2010
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-010-1540-5

At a glance: The STEP trials

Springer Medicine

Oxygen uptake kinetics during exercise in adults with Down syndrome

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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