Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Critical Care
Published in: Critical Care 1/2015

Open Access 01-12-2015 | Commentary

Oxygen - a limiting factor for brain recovery

Authors: Amir Hadanny, Shai Efrati

Published in: Critical Care | Issue 1/2015

Login to get access

Abstract

Effective brain metabolism is highly dependent on a narrow therapeutic window of oxygen. In major insults to the brain (e.g., intracerebral hemorrhage), a slight decrease in oxygen supply, as occurs in a hypobaric environment at high altitude, has devastating effects on the injured brain tissue. Conversely, increasing brain oxygenation, by the use of hyperbaric oxygen therapy, can improve brain metabolism and its dependent regenerative processes.
Literature
1.
Zhu HT, Bian C, Yuan JC, Liao XJ, Liu W, Zhu G, et al. Hyperbaric oxygen therapy ameliorates acute brain injury after porcine intracerebral hemorrhage at high altitude. Crit Care. 2015;19:255.CrossRef
2.
Zauner A, Daugherty WP, Bullock MR, Warner DS. Brain oxygenation and energy metabolism: part I-biological function and pathophysiology. Neurosurgery. 2002;51:289–301.PubMed
3.
Efrati S, Ben-Jacob E. Reflections on the neurotherapeutic effects of hyperbaric oxygen. Expert Rev Neurother. 2014;14:233–6.CrossRef
4.
Boussi-Gross R, Golan H, Volkov O, Bechor Y, Hoofien D, Schnaider Beeri M, et al. Improvement of memory impairments in poststroke patients by hyperbaric oxygen therapy. Neuropsychology. 2015;29:610–21.CrossRef
5.
Efrati S, Fishlev G, Bechor Y, Volkov O, Bergan J, Kliakhandler K, et al. Hyperbaric oxygen induces late neuroplasticity in post stroke patients—randomized, prospective trial. PLoS One. 2013;8, e53716.CrossRef
6.
Boussi-Gross R, Golan H, Fishlev G, Bechor Y, Volkov O, Bergan J, et al. Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury—randomized prospective trial. PLoS One. 2013;8, e79995.CrossRef
Metadata
Title
Oxygen - a limiting factor for brain recovery
Authors
Amir Hadanny
Shai Efrati
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2015
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-015-1034-2

Other articles of this Issue 1/2015

Critical Care 1/2015 Go to the issue

Research

Platelet mitochondrial dysfunction in critically ill patients: comparison between sepsis and cardiogenic shock

Letter

Altering the mechanical scenario to decrease the driving pressure

Research

Does inferior vena cava respiratory variability predict fluid responsiveness in spontaneously breathing patients?

Letter

Peri-operative fluid strategy and post-operative acute kidney injury in cardiac surgery patients: any role for pre-operative statin therapy?

Letter

Fluid bolus therapy is a medical therapy or a diagnostic method?

Research

Timing of tracheotomy in ICU patients: a systematic review of randomized controlled trials