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01-10-2015 | Note

Oxomollugin, a potential inhibitor of lipopolysaccharide-induced nitric oxide production including nuclear factor kappa B signals

Authors: Hiroshi Morita, Hitomi Nishino, Yuki Nakajima, Yoshiaki Kakubari, Asami Nakata, Jun Deguchi, Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda, Yoko Kawasaki, Yukihiro Goda

Published in: Journal of Natural Medicines | Issue 4/2015

Abstract

Mollugin, a naphthoquinone derivative, was reported to possess various biological activities such as anti-inflammatory and anti-tumor activity. Mollugin isolated from Rubia tinctorum roots inhibited lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 macrophages. However, mollugin synthesized for further investigation of its anti-inflammatory mechanism showed weak activity in addition to unstable assay results. From the result of analysis on a degradation product of mollugin, oxomollugin was found to be the main active substance of mollugin degradation, showing a potent inhibitory activity on NO-production including nuclear factor kappa B signals.

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Title: Oxomollugin, a potential inhibitor of lipopolysaccharide-induced nitric oxide production including nuclear factor kappa B signals
Authors: Hiroshi Morita
Hitomi Nishino
Yuki Nakajima
Yoshiaki Kakubari
Asami Nakata
Jun Deguchi
Alfarius Eko Nugroho
Yusuke Hirasawa
Toshio Kaneda
Yoko Kawasaki
Yukihiro Goda
Publication date: 01-10-2015
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 4/2015
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-015-0927-3

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Oxomollugin, a potential inhibitor of lipopolysaccharide-induced nitric oxide production including nuclear factor kappa B signals

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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